Patents by Inventor Stephanie TAGLIATELA

Stephanie TAGLIATELA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TISSUE SELECTIVE TRANSGENE EXPRESSION
    Publication number: 20230203531
    Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (for example, cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
    Type: Application
    Filed: November 16, 2022
    Publication date: June 29, 2023
    Inventors: Stephanie TAGLIATELA, Andrew Young, Szu-Ying Chen, Kartik Ramamoorthi, David Oberkofler
  • COMPOSITIONS AND METHODS FOR TREATING LAMINOPATHIES
    Publication number: 20220193264
    Abstract: The present disclosure provides compositions and methods for treating, preventing, or inhibiting laminopathies. In one aspect, the disclosure provides nucleic acid constructs and/or vectors comprising a nucleotide sequence encoding lamin A and/or lamin C.
    Type: Application
    Filed: February 28, 2020
    Publication date: June 23, 2022
    Inventors: Sirika Wood, Kartik Ramamoorthi, Stephanie Tagliatela, Anne Tanenhaus
  • MULTIPLEXING REGULATORY ELEMENTS TO IDENTIFY CELL-TYPE SPECIFIC REGULATORY ELEMENTS
    Publication number: 20220170910
    Abstract: Provided herein is a high-throughput method for screening and identifying regulatory elements that provide selective expression in a particular cell type of interest. Also provided are nucleic acid compositions used in the high-throughput screening method.
    Type: Application
    Filed: March 20, 2020
    Publication date: June 2, 2022
    Inventors: Kartik Ramamoorthi, Anne Tanenhaus, Sirika Wood, Martin Moorhead, Stephanie Tagliatela, Jerry S. Chen, Raghavendra Hosur
  • COMPOSITIONS AND METHODS FOR ADMINISTRATION OF THERAPEUTICS
    Publication number: 20220168449
    Abstract: Provided herein are methods for administering a vector comprising a cell-type selective regulatory element. Such methods of administering comprise administration of one or more nucleic acid molecules to the central nervous system using methods such as intracerebroventricular administration, intrathecal administration, or intravenous administration.
    Type: Application
    Filed: April 10, 2020
    Publication date: June 2, 2022
    Inventors: Archana Belle, Stephanie Tagliatela
  • COMPOSITIONS AND METHODS FOR SELECTIVE GENE REGULATION
    Publication number: 20220136009
    Abstract: Provided herein are engineered transcription factors for selective upregulation of SCN1a and uses thereof for treating diseases and disorders, such as, Dravet syndrome. Also provided are microRNA binding sites and uses thereof for selective expression in parvalbumin neurons.
    Type: Application
    Filed: November 10, 2021
    Publication date: May 5, 2022
    Inventors: Stephanie TAGLIATELA, Anne TANENHAUS, Kartik RAMAMOORTHI, Andrew YOUNG, David OBERKOFLER
  • COMPOSITIONS AND METHODS FOR TREATING WILSON'S DISEASE
    Publication number: 20210369870
    Abstract: Provided herein are nucleic acid molecules and vectors comprising variant copper transporting ATPase 2 (ATP7B) nucleic acid sequences. Such sequences have been optimized for expression in mammalian cells, liver cells, and/or from an adeno associated viral vector (AAV), including truncated and/or codon optimized variants. Also provided are viral vectors comprising such ATP7B variant nucleic acid sequences, and methods of use thereof for treating disorders associated with an ATP7B deficiency, such as Wilsons disease.
    Type: Application
    Filed: November 15, 2019
    Publication date: December 2, 2021
    Inventors: Kartik RAMAMOORTHI, Stephanie TAGLIATELA, Anne TANENHAUS, Andrew YOUNG, Szu-Ying CHEN, Chi ZHANG, Stephanie MARTIN, David OBERKOFLER, Victoria WONG, Jianmin LI
  • ENGINEERED DNA BINDING PROTEINS
    Publication number: 20200397917
    Abstract: Provided herein are compositions and methods of use thereof comprising a non-naturally occurring DNA binding protein that modulates expression of an endogenous gene.
    Type: Application
    Filed: May 28, 2020
    Publication date: December 24, 2020
    Inventors: Stephanie TAGLIATELA, Anne TANENHAUS, Kartik RAMAMOORTHI, Andrew YOUNG, David OBERKOFLER
  • HIGH ACTIVITY REGULATORY ELEMENTS
    Publication number: 20200231943
    Abstract: Provided herein are compositions and methods for driving high expression of a transgene. Compositions and methods for driving high expression of a transgene comprising one or more human-derived regulatory elements, which, when operably linked to a transgene, can result in high expression of the transgene in one or more cell types or tissues.
    Type: Application
    Filed: November 18, 2019
    Publication date: July 23, 2020
    Inventors: Kartik RAMAMOORTHI, Stephanie TAGLIATELA, Anne TANENHAUS, Andrew YOUNG, Szu-Ying CHEN, Chi ZHANG, Stephanie MARTIN, David OBERKOFLER
  • TISSUE SELECTIVE TRANSGENE EXPRESSION
    Publication number: 20200165628
    Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
    Type: Application
    Filed: October 31, 2019
    Publication date: May 28, 2020
    Inventors: Stephanie TAGLIATELA, Andrew YOUNG, Szu-Ying CHEN, Kartik RAMAMOORTHI, David OBERKOFLER
  • Tissue selective transgene expression
    Patent number: 10519465
    Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: December 31, 2019
    Assignee: Encoded Therapeutics, Inc.
    Inventors: Stephanie Tagliatela, Andrew Young, Szu-Ying Chen, Kartik Ramamoorthi, David Oberkofler
  • Tissue selective transgene expression
    Patent number: 10287607
    Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: May 14, 2019
    Assignee: Encoded Therapeutics, Inc.
    Inventors: Stephanie Tagliatela, Andrew Young, Szu-Ying Chen, Kartik Ramamoorthi, David Oberkofler
  • Tissue selective transgene expression
    Patent number: 10287608
    Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: May 14, 2019
    Assignee: Encoded Therapeutics, Inc.
    Inventors: Stephanie Tagliatela, Andrew Young, Szu-Ying Chen, Kartik Ramamoorthi, David Oberkofler
  • TISSUE SELECTIVE TRANSGENE EXPRESSION
    Publication number: 20190024118
    Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
    Type: Application
    Filed: October 5, 2018
    Publication date: January 24, 2019
    Inventors: Stephanie TAGLIATELA, Andrew YOUNG, Szu-Ying CHEN, Kartik RAMAMOORTHI, David OBERKOFLER
  • TISSUE SELECTIVE TRANSGENE EXPRESSION
    Publication number: 20190024119
    Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
    Type: Application
    Filed: October 5, 2018
    Publication date: January 24, 2019
    Inventors: Stephanie Tagliatela, Andrew Young, Szu-Ying Chen, Kartik Ramamoorthi, David Oberkofler
  • TISSUE SELECTIVE TRANSGENE EXPRESSION
    Publication number: 20190024120
    Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
    Type: Application
    Filed: October 5, 2018
    Publication date: January 24, 2019
    Inventors: Stephanie TAGLIATELA, Andrew YOUNG, Szu-Ying CHEN, Kartik RAMAMOORTHI, David OBERKOFLER
  • TISSUE SELECTIVE TRANSGENE EXPRESSION
    Publication number: 20190024121
    Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
    Type: Application
    Filed: October 5, 2018
    Publication date: January 24, 2019
    Inventors: Stephanie TAGLIATELA, Andrew YOUNG, Szu-Ying CHEN, Kartik RAMAMOORTHI, David OBERKOFLER