Abstract: The present disclosure relates to modified extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), which is capable of reducing and/or inhibiting expression of KRAS mRNA and/or KRAS protein. ASOs that can be used with the modified extracellular vesicles are also disclosed. Also provided herein are methods for using the exosomes and ASOs to treat and/or prevent diseases, such as cancer.

Abstract: Systems, computer storage media, and methods for real-time rendering based on efficient device and server processing of content updates. One of the methods includes presenting user interface information that includes multiple visual portions associated with input of types of code. User input of code with respect to one or more of the visual portions is received, and code input in a particular visual portion includes code to be compiled and/or imports associated with particular libraries. Rendering of the input code is caused, and the rendering is presented in an output visual portion. A system can receive the code input in the particular visual portion over a network. The system can compile the received code and package the received code with associated libraries. The system can provide the packaged code to the user device to be interpreted during rendering of the input code.

Abstract: Systems and methods for developing one or more applications associated with a browser-based user interface within a multi-developer computing platform employ one or more processors that receive a request to build one or more applications configured to run in a browser-based user interface on a client; determine whether the one or more applications are associated with a core library and one or more runtime libraries; and in response to determining that the one or more applications are associated with the core library and the one or more runtime libraries: determine one or more version numbers associated with the one or more runtime libraries; and in response to the determined one or more version numbers being within a predetermined range associated with the core library, dynamically link the one or more runtime libraries and the one or more applications.

Abstract: Systems and methods for developing one or more applications associated with a browser-based user interface within a multi-developer computing platform employ one or more processors that receive a request to build one or more applications configured to run in a browser-based user interface on a client; determine whether the one or more applications are associated with a core library and one or more runtime libraries; and in response to determining that the one or more applications are associated with the core library and the one or more runtime libraries: determine one or more version numbers associated with the one or more runtime libraries; and in response to the determined one or more version numbers being within a predetermined range associated with the core library, dynamically link the one or more runtime libraries and the one or more applications.

Abstract: Systems and methods for developing one or more applications associated with a browser-based user interface within a multi-developer computing platform employ one or more processors that receive a request to build one or more applications configured to run in a browser-based user interface on a client; determine whether the one or more applications are associated with a core library and one or more runtime libraries; and in response to determining that the one or more applications are associated with the core library and the one or more runtime libraries: determine one or more version numbers associated with the one or more runtime libraries; and in response to the determined one or more version numbers being within a predetermined range associated with the core library, dynamically link the one or more runtime libraries and the one or more applications.

Abstract: A hydraulic fracture fluid is provided. The fluid can include a liquid solvent, one or more surfactants, a proppant-forming compound, and one or more curing agents. The liquid reacts to form proppant in-situ under downhole conditions.

Abstract: A system is configured to provide a dashboard creation system. Panels associated with queries for retrieving information from a database are shown in a user interface. Various other user interfaces show query code, panel display settings, function code, dependencies, etc. Queries in a first query format access a data source. Queries in a second query format access a cache database that is synchronized with the data source.

Abstract: A hydraulic fracture fluid is provided. The fluid can include a liquid solvent, one or more surfactants, a proppant-forming compound, and one or more curing agents. The liquid reacts to form proppant in-situ under downhole conditions.

Abstract: A thinner that is a poly fatty amide reacted with maleic acid to form a product, and diluting the product with a compound selected from the group consisting of oleyl alcohol, fatty acid, and poly condensed fatty acid is able to reduce the viscosity of oil-based drilling fluid, thus allowing for reuse of the oil-based drilling fluid.

Abstract: A system is configured to provide a dashboard creation system. Panels associated with queries for retrieving information from a database are shown in a user interface. Various other user interfaces show query code, panel display settings, function code, dependencies, etc. Queries in a first query format access a data source. Queries in a second query format access a cache database that is synchronized with the data source.

Abstract: A system is configured to provide a dashboard creation system. Panels associated with queries for retrieving information from a database are shown in a user interface. Various other user interfaces show query code, panel display settings, function code, dependencies, etc. The dependencies can be extracted and used to provide autocomplete and partial refreshing. A timing table shows execution times. Panel outputs and code updates can be shown and compared.

Abstract: A hydraulic fracture fluid is provided. The fluid can include a liquid solvent, one or more surfactants, a proppant-forming compound, and one or more curing agents. The liquid reacts to form proppant in-situ under downhole conditions.

Abstract: Systems, computer storage media, and methods for real-time rendering based on efficient device and server processing of content updates. One of the methods includes presenting user interface information that includes multiple visual portions associated with input of types of code. User input of code with respect to one or more of the visual portions is received, and code input in a particular visual portion includes code to be compiled and/or imports associated with particular libraries. Rendering of the input code is caused, and the rendering is presented in an output visual portion. A system can receive the code input in the particular visual portion over a network. The system can compile the received code and package the received code with associated libraries. The system can provide the packaged code to the user device to be interpreted during rendering of the input code.

Abstract: Systems, computer storage media, and methods for real-time rendering based on efficient device and server processing of content updates. One of the methods includes presenting user interface information that includes multiple visual portions associated with input of types of code. User input of code with respect to one or more of the visual portions is received, and code input in a particular visual portion includes code to be compiled and/or imports associated with particular libraries. Rendering of the input code is caused, and the rendering is presented in an output visual portion. A system can receive the code input in the particular visual portion over a network. The system can compile the received code and package the received code with associated libraries. The system can provide the packaged code to the user device to be interpreted during rendering of the input code.

Abstract: A system is configured to provide a dashboard creation system. Panels associated with queries for retrieving information from a database are shown in a user interface. Various other user interfaces show query code, panel display settings, function code, dependencies, etc. The dependencies can be extracted and used to provide autocomplete and partial refreshing. A timing table shows execution times. Panel outputs and code updates can be shown and compared.

Abstract: A system is configured to provide a dashboard creation system. Panels associated with queries for retrieving information from a database are shown in a user interface. Various other user interfaces show query code, panel display settings, function code, dependencies, etc. The dependencies can be extracted and used to provide autocomplete and partial refreshing. A timing table shows execution times. Panel outputs and code updates can be shown and compared.

Abstract: The systems and methods described herein provide highly dynamic and interactive data analysis user interfaces which enable data analysts to quickly and efficiently explore large volume data sources. The data analysis system enables the user to investigate large volumes of data over many different paths of analysis while maintaining detailed and retraceable steps taken by the user over the course of an investigation, as captured via the user's queries and user interaction with the user interfaces provided by the data analysis system. Data analysis paths may involve exploration of high volume data sets, such as Internet proxy data, which may include trillions of rows of data. The data analyst may pursue a data analysis path that involves, among other things, applying filters, joining to other tables in a database, viewing interactive data visualizations, and so on. The data analysis system enables a user to refresh or insert a node in a workflow.

Abstract: A system is configured to provide a dashboard creation system. Panels associated with queries for retrieving information from a database are shown in a user interface. Various other user interfaces show query code, panel display settings, function code, dependencies, etc. Queries in a first query format access a data source. Queries in a second query format access a cache database that is synchronized with the data source.

Abstract: A system is configured to provide a dashboard creation system. Panels associated with queries for retrieving information from a database are shown in a user interface. Various other user interfaces show query code, panel display settings, function code, dependencies, etc. The dependencies can be extracted and used to provide autocomplete and partial refreshing. A timing table shows execution times. Panel outputs and code updates can be shown and compared.

Abstract: The present invention provides methods for the regulation of osteopontin activity in a subject as well as for treating or preventing conditions associated with an increased activity of osteopontin activity in a subject.