Abstract: A hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a substantially non-expandable, non-compressible prosthetic valve member having a peripheral sealing ring and an expandable stent frame projecting from an inflow end, thereby enabling attachment to the annulus without sutures. The stent frame may be plastically-expandable and may have a thin fabric layer covering its entirety as well as secondary sealing structures around its periphery to prevent paravalvular leaking. Other sealing solutions include interactive steps at the time of valve implant to establish seals around the stent and especially between the stent and the sealing ring of the valve member.

Abstract: Described herein are therapeutic pH responsive compositions comprising a block copolymer and a therapeutic agent useful for the treatment of cancer.

Abstract: The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: Multispecific antibody having a binding site for ICOS and a binding site for a second antigen, e.g., an immune checkpoint molecule such as PD-L1. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours.

Abstract: Presented herein are techniques for monitoring the insertion of an intra-cochlear stimulating assembly for the occurrence of one or more insertion stop conditions. The insertion stop conditions are detectable events indicating that movement of the stimulating assembly into a recipient's cochlea should be at least temporarily stopped. The insertion monitoring is based on objectively measured inner ear potentials, such as acoustically-evoked potentials.

Abstract: Presented herein are techniques that make use of objective measurements obtained in response to acoustic stimulation signals. More specifically, at least one measure of outer hair cell function and at least one measure of auditory nerve function are obtained from a tonotopic region of an inner ear of a recipient of a hearing prosthesis. The at least one measure of auditory nerve function and the least one measure of outer hair cell function are then analyzed relative to one another.

Abstract: A prosthetic hand with a waterproof cover and/or a filament-based digit securement mechanism. A first annular recess on the digit aligns with a second corresponding annular recess on a chassis to form a groove into which the filament is inserted. The prosthetic hand may comprise a waterproof cover that protects the interior components of the prosthetic hand. A thumb cover and a dorsal cover attach to a palm cover. A thumb cover interface is adhered via a clamp with an exterior sealing ring. A dorsal cover interface has a sealing ring. The thumb cover may be flexible and have three layers. The dorsal cover may be rigid and have a latch that snaps onto the chassis. The cover may be put onto the palm portion with the thumb and thumb cover, and then the prosthetic digits may be attached to the chassis thereafter.

Abstract: A process for forming an active cathode material. The process comprises forming a precursor comprising a lithium salt and a multi-carboxylic acid salt of at least one of nickel, manganese or cobalt; heating the precursor in a metal lined vessel to a temperature of no more than 600° C. to form an intermediate material; and heating the intermediate material to a temperature of over 600° C. to form said active cathode material.

Abstract: A process of forming recycled cathode active material, particularly from depleted cathode active material from a battery, comprising: forming black mass from the depleted cathode active material; digesting the black mass with a carboxylic acid to form delithiated cathode active material precursor; adding virgin lithium salt to the delithiated cathode active material precursor to form cathode active material precursor; and calcining the cathode active material precursor to form the recycled cathode active material.

Abstract: Provided is an improved method for forming a coated lithium ion cathode materials specifically for use in a battery. The method comprises forming a first solution comprising a digestible feedstock of a first metal suitable for formation of a cathode oxide precursor and a multi-carboxylic acid. The digestible feedstock is digested to form a first metal salt in solution wherein the first metal salt precipitates as a salt of deprotonated multi-carboxylic acid thereby forming an oxide precursor and a coating metal is added to the oxide precursor. The oxide precursor is heated to form the coated lithium ion cathode material.

Abstract: A stabilized lithium ion cathode material comprising a calcined manganese oxide powder wherein the manganese on a surface is MnPO4, comprises an manganese phosphate bond, or the phosphate is bonded to the surface of the cathode material.

Abstract: Provided is an improved method for forming a coated lithium ion cathode materials specifically for use in a battery. The method comprises forming a first solution comprising a digestible feedstock of a first metal suitable for formation of a cathode oxide precursor and a multi-carboxylic acid. The digestible feedstock is digested to form a first metal salt in solution wherein the first metal salt precipitates as a salt of deprotonated multi-carboxylic acid thereby forming an oxide precursor and a coating metal is added to the oxide precursor. The oxide precursor is heated to form the coated lithium ion cathode material.

Abstract: An improved process for forming a lithium metal phosphate cathode material is provided. The process comprises reacting a metal source, a phosphate containing acid such as phosphoric acid, and an organic acid in solvent to form a metal phosphate. A lithium source is added to the solvent and a precipitate is allowed to form. The precipitate is dried and calcined thereby forming lithium iron phosphate cathode material wherein the lithium iron phosphate cathode material comprises up to 3 wt % carbon.

Abstract: A method of forming an improved calcined lithium metal oxide is provided wherein the metal comprises at least one of nickel, manganese and cobalt. The method comprises forming a first solution in a first reactor wherein the first solution comprises at least one first salt of at least one of lithium, nickel, manganese or cobalt in a first solvent. A second solution is formed wherein the second solution comprises a second salt of at least one of lithium, nickel, manganese or cobalt in a second solvent wherein the second salt is not present in the first solution. A gas in introduced into said first solution to form a gas saturated first solution. A second solution is added to the gas saturated first solution without bubbling to form a lithium metal salt. The lithium metal salt dried and calcined to form the calcined lithium metal oxide.

Abstract: A process for forming an active cathode material. The process comprises forming a precursor comprising a lithium salt and a multi-carboxylic acid salt of at least one of nickel, manganese or cobalt; heating the precursor in a metal lined vessel to a temperature of no more than 600° C. to form an intermediate material; and heating the intermediate material to a temperature of over 600° C. to form said active cathode material.

Abstract: A method of forming an improved calcined lithium metal oxide is provided wherein the metal comprises at least one of nickel, manganese and cobalt. The method comprises forming a first solution in a first reactor wherein the first solution comprises at least one first salt of at least one of lithium, nickel, manganese or cobalt in a first solvent. A second solution is formed wherein the second solution comprises a second salt of at least one of lithium, nickel, manganese or cobalt in a second solvent wherein the second salt is not present in the first solution. A gas in introduced into said first solution to form a gas saturated first solution. A second solution is added to the gas saturated first solution without bubbling to form a lithium metal salt. The lithium metal salt dried and calcined to form the calcined lithium metal oxide.

Abstract: Provided herein is a computer-implemented method of managing plant data. The method includes storing first plant data on a user device connected to a server. The first plant data relates to growth of a plant in a first grower device. The method also includes collecting second plant data related to growth of the plant in a second grower device. The second grower device is for growth of the plant moved from the first grower device. The second plant data is collected by the second grower device. The method also includes transferring the first plant data and the second plant data to the server. The method also includes displaying the first plant data and the second plant data on the user device.

Abstract: A method of forming an improved calcined lithium metal oxide is provided wherein the metal comprises at least one of nickel, manganese and cobalt. The method comprises forming a first solution in a first reactor wherein the first solution comprises at least one first salt of at least one of lithium, nickel, manganese or cobalt in a first solvent. A second solution is formed wherein the second solution comprises a second salt of at least one of lithium, nickel, manganese or cobalt in a second solvent wherein the second salt is not present in the first solution. A gas in introduced into said first solution to form a gas saturated first solution. A second solution is added to the gas saturated first solution without bubbling to form a lithium metal salt. The lithium metal salt dried and calcined to form the calcined lithium metal oxide.

Abstract: The present invention provides a method for forming a lithium ion cathode material. The method comprises reacting elemental metal with a multi-carboxylic acid to form an oxide precursor and heating the oxide precursor to form the lithium ion cathode material. In a preferred embodiment the elemental mixture comprises at least two of Ni, Mn, Co and Al.

Abstract: There is described a dental prosthesis for forming a friction fit attachment to a dental implant or dental connector. The prosthesis comprises a release device comprising a release member that is movable relative to the prosthesis from a first position to a second position. When the release member is in the first position the release device is not operable to impart a separating force to a friction fit attachment between the implant or connector and the prosthesis and when the release member is in the second position the release device is operable to impart a separating force to a friction fit attachment between the implant or connector and the prosthesis.