Patents by Inventor Stephen A. GRAVINA

Stephen A. GRAVINA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240122220
    Abstract: Newly identified fungal sweet-taste modifying proteins, and the cDNA encoding said proteins are described. Specifically, Myd proteins active in sweet taste activation, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed is use of a sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.
    Type: Application
    Filed: November 13, 2023
    Publication date: April 18, 2024
    Applicant: MycoTechnology, Inc.
    Inventors: Marina NADAL, Anthony J. CLARK, Zheyuan GUO, Stephen A. GRAVINA, Anthony WESTGATE, Bassam ALKOTAINI, Ashley HAN, Brendan SHARKEY, Evan STRASSBURGER, Joseph MEILEN, Hyung CHANG, Alan D. HAHN
  • Publication number: 20230210154
    Abstract: Newly identified fungal sweet-taste modifying proteins (designated Honey Truffle Sweetener (HTS)), and polynucleotides encoding the proteins are described. Specifically, Myd proteins with sweet taste modulation activity, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed are sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.
    Type: Application
    Filed: December 27, 2022
    Publication date: July 6, 2023
    Inventors: Marina NADAL, Anthony J. CLARK, Zheyuan GUO, Stephen A. GRAVINA, Anthony WESTGATE, Bassam ALKOTAINI, Ashley HAN, Brendan SHARKEY, Evan STRASSBURGER, Joseph MEILEN, James Patrick LANGAN
  • Publication number: 20220183333
    Abstract: Newly identified fungal sweet-taste modifying proteins, and the cDNA encoding said proteins are described. Specifically, Myd proteins active in sweet taste activation, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed is use of a sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.
    Type: Application
    Filed: February 25, 2022
    Publication date: June 16, 2022
    Applicant: MycoTechnology, Inc.
    Inventors: Marina NADAL, Anthony J. CLARK, Zheyuan GUO, Stephen A. GRAVINA, Anthony WESTGATE, Bassam ALKOTAINI, Ashley HAN, Brendan SHARKEY, Evan STRASSBURGER, Joseph MEILEN, Hyung CHANG
  • Patent number: 11297861
    Abstract: Newly identified fungal sweet-taste modifying proteins, and the cDNA encoding said proteins are described. Specifically, Myd proteins active in sweet taste activation, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed is use of a sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: April 12, 2022
    Assignee: MycoTechnology, Inc.
    Inventors: Marina Nadal, Anthony J. Clark, Zheyuan Guo, Stephen A. Gravina, Anthony Westgate, Bassam Alkotaini, Ashley Han, Brendan Sharkey, Evan Strassburger, Joseph Meilen, Hyung Chang
  • Patent number: 11259536
    Abstract: Processing of milk raw material produces a dairy salt. Preliminary treatment of the milk raw is carried out, with pasteurization and its concentration by nanofiltration through a filter with a pore size of 0.001-0.01 ?m, subsequent filtration of the obtained nanofiltration permeate through a membrane module with a pore size of 0.0001-0.001 ?m of a reverse osmosis unit, electrodialysis of the obtained RO retentate, concentration of the concentrate or its concentration and drying. The dairy salts may be manufactured and used to salt food products, beverages, granulated cottage cheese, potato chips, crackers, and dips. A masking fraction with organic acid, amino acid, fatty acid, and sugar portions successfully hides the off-notes otherwise associated with potassium compositions. Food products salted with any of the dairy salts described herein achieve reduced sodium content without compromising flavor.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: March 1, 2022
    Assignee: Wimm-Bill-Dann OJSC
    Inventors: Grigoriy A. Dudarev, Stephen Gravina, Sivaraj Kaliappan, Sergey N. Knyazev, Yuliya Kurash, Maksim N. Omarov, Sergey I. Perminov, Vitaliy S. Somov, James William Stalder
  • Publication number: 20210401013
    Abstract: Newly identified fungal sweet-taste modifying proteins, and the cDNA encoding said proteins are described. Specifically, Myd proteins active in sweet taste activation, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed is use of a sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.
    Type: Application
    Filed: June 25, 2021
    Publication date: December 30, 2021
    Inventors: Marina NADAL, Anthony J. CLARK, Zheyuan GUO, Stephen A. GRAVINA, Anthony WESTGATE, Bassam ALKOTAINI, Ashley HAN, Brendan SHARKEY, Evan STRASSBURGER, Joseph Meilen, Hyung Chang
  • Patent number: 10966447
    Abstract: The present disclosure provides novel sweetener compositions comprising a compound having a structure according to Formula I: wherein R1, R2, R3, and R4 are described herein. Also provided are methods of modulating sweetness profile of a product by adding a compound of Formula I to the product, such as a beverage product or a food product. For example, the compound described herein can be added to increase the overall sweetness of a nutritive sweetener sweetened beverages; decrease the sweetness time-of-onset for high potency sweeteners such as rebaudioside A; decreasing bitter, metallic and licorice off-notes of high potency sweeteners; and improve the sweet quality of sweetened products.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: April 6, 2021
    Assignee: PepsiCo, Inc.
    Inventors: Shawn Erickson, Yu-Wen Feng, Christophe Galopin, Stephen Gravina, Yuliya Kurash, Thomas Lee, Laura Nattress, Ting Wang
  • Publication number: 20200337325
    Abstract: Processing of milk raw material produces a dairy salt. Preliminary treatment of the milk raw is carried out, with pasteurization and its concentration by nanofiltration through a filter with a pore size of 0.001-0.01 ?m, subsequent filtration of the obtained nanofiltration permeate through a membrane module with a pore size of 0.0001-0.001 ?m of a reverse osmosis unit, electrodialysis of the obtained RO retentate, concentration of the concentrate or its concentration and drying. The dairy salts may be manufactured and used to salt food products, beverages, granulated cottage cheese, potato chips, crackers, and dips. A masking fraction with organic acid, amino acid, fatty acid, and sugar portions successfully hides the off-notes otherwise associated with potassium compositions. Food products salted with any of the dairy salts described herein achieve reduced sodium content without compromising flavor.
    Type: Application
    Filed: July 8, 2020
    Publication date: October 29, 2020
    Inventors: Grigoriy A. DUDAREV, Stephen GRAVINA, Sivaraj KALIAPPAN, Sergey N. KNYAZEV, Yuliya KURASH, Maksim N. OMAROV, Sergey I. PERMINOV, Vitaliy S. SOMOV, James William STALDER
  • Patent number: 10107794
    Abstract: Co-expression of T1R2 and T1R3 results in a taste receptor that responds to sweet taste stimuli, including naturally occurring and artificial sweeteners. Cells such as U2-OS, which express a functional sweet receptor, can be used in cell-based assays to detect cellular responses to tastants.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: October 23, 2018
    Assignee: PepsiCo, Inc.
    Inventors: Yuliya Kurash, Stephen Gravina
  • Publication number: 20180020708
    Abstract: The present disclosure provides novel sweetener compositions comprising a compound having a structure according to Formula I: wherein R1, R2, R3, and R4 are described herein. Also provided are methods of modulating sweetness profile of a product by adding a compound of Formula I to the product, such as a beverage product or a food product. For example, the compound described herein can be added to increase the overall sweetness of a nutritive sweetener sweetened beverages; decrease the sweetness time-of-onset for high potency sweeteners such as rebaudioside A; decreasing bitter, metallic and licorice off-notes of high potency sweeteners; and improve the sweet quality of sweetened products.
    Type: Application
    Filed: July 19, 2016
    Publication date: January 25, 2018
    Inventors: Shawn Erickson, Yu-Wen FENG, Christophe GALOPIN, Stephen GRAVINA, Yuliya KURASH, Thomas LEE, Laura NATTRESS, Ting WANG
  • Patent number: 9766236
    Abstract: This disclosure provides a taste receptor internalization assay useful for identifying taste modulators.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: September 19, 2017
    Assignee: PEPSICO, INC.
    Inventors: Yuliya Kurash, Stephen Gravina
  • Publication number: 20160324175
    Abstract: Processing of milk raw material produces a dairy salt. Preliminary treatment of the milk raw is carried out, with pasteurization and its concentration by nanofiltration through a filter with a pore size of 0.001-0.01 ?m, subsequent filtration of the obtained nanofiltration permeate through a membrane module with a pore size of 0.0001-0.001 ?m of a reverse osmosis unit, electrodialysis of the obtained RO retentate, concentration of the concentrate or its concentration and drying. The dairy salts may be manufactured and used to salt food products, beverages, granulated cottage cheese, potato chips, crackers, and dips. A masking fraction with organic acid, amino acid, fatty acid, and sugar portions successfully hides the off-notes otherwise associated with potassium compositions. Food products salted with any of the dairy salts described herein achieve reduced sodium content without compromising flavor.
    Type: Application
    Filed: December 1, 2014
    Publication date: November 10, 2016
    Inventors: Grigoriy A. DUDAREV, Stephen GRAVINA, Sivaraj KALIAPPAN, Sergey N. KNYAZEV, Yuliya KURASH, Maksim N. OMAROV, Sergey I. PERMINOV, Vitaliy S. SOMOV, James William STALDER
  • Publication number: 20160316799
    Abstract: A beverage comprising water, at least one non-nutritive sweetener having a bitter off-note taste, linoleic acid, and heptanoic acid. A beverage comprising water, at least one non-nutritive sweetener, a combination of caprylic acid, caproic acid, and butyric acid, and at least one aldehyde selected from the group consisting of decanal, nonanal, and 2-methyl-butyraldehyde.
    Type: Application
    Filed: December 8, 2014
    Publication date: November 3, 2016
    Inventors: Anthony AGLIONE, Kelly J. CASSUTT, Sofya DRAGAN, Stephen GRAVINA, Yuliya KURASH, Winsome JOHNSON
  • Publication number: 20160091488
    Abstract: Co-expression of T1R2 and T1R3 results in a taste receptor that responds to sweet taste stimuli, including naturally occurring and artificial sweeteners. Cells such as U2-OS, which express a functional sweet receptor, can be used in cell-based assays to detect cellular responses to tastants.
    Type: Application
    Filed: May 9, 2014
    Publication date: March 31, 2016
    Inventors: Yuliya KURASH, Stephen GRAVINA
  • Publication number: 20160084834
    Abstract: This disclosure provides a taste receptor internalization assay useful for identifying taste modulators.
    Type: Application
    Filed: May 9, 2014
    Publication date: March 24, 2016
    Inventors: Yuliya KURASH, Stephen GRAVINA