Abstract: A handheld vacuum cleaner includes a dirt separator. The dirt separator includes a chamber having an inlet through which dirt-laden fluid enters and an outlet through which cleansed fluid exits the chamber. A disc located at the outlet rotates about a rotational axis and comprises holes through which the cleansed fluid passes.

Abstract: The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.

Abstract: Devices, systems, and methods for quantifying applied pressure by a device against an area of tissue. In particular, the present technology is related to medical devices including an optical element with a fiber Bragg grating, systems including the medical devices, and methods of quantifying applied pressure by the medical device. In one embodiment, a medical device comprises an elongate body including a distal portion and a proximal portion opposite the distal portion, and an optical element located at the distal portion of the elongate body. In one embodiment, the optical element include an optical fiber with a fiber Bragg grating. In one embodiment, the medical device is part of a medical system comprising a control unit in communication with the medical device, the control unit including an optical interrogator in communication with the optical element and processing circuitry configured to receive data from the optical interrogator.

Abstract: An inventory system, apparatus and method. The method to be used in a cooler that includes a power module provides power to the inventory system from an electric source, battery, WIFI charge, wireless charge and/or combination thereof, a computer processor coupled to the power module, a memory module coupled to the computer processor, an image capturing module coupled to the processor, a movement module coupled to the processor; wherein the movement module triggers the image capturing device to capture images of products in a cooler due to a movement.

Abstract: A system 10 for delivering respiratory therapy to a patient includes a patient interface device 20 for delivering pressurized gas to a patient, a connector system 60 for connection to a source of pressurized gas and a conduit system 40 fluidly connecting the connector system 60 to the patient interface device 20. The connector system 60 includes a plurality of closable ports 68, 32 that allow a plurality of different modes of respiratory therapy to be provided. The conduit system 40 may include a first gas line 42, a second gas line 46 and a third gas line 46. The second gas line 46 and third gas line 44 may be contained within the first gas line 42 along at least part of their length.

Abstract: This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.

Abstract: A transseptal system includes a needle, a guidewire, a handle, and a dilator. The handle defines a needle passage to slidably receive the needle, and a guidewire passage to slidably receive the guidewire. The dilator defines a lumen having a distal region and a proximal region. The dilator is coupled to the handle such that the lumen is open to the needle passage and the guidewire passage. The proximal region of the lumen is sized to simultaneously receive the needle body and the guidewire. The distal region is sized to slidably receive one of the needle and the guidewire on an individual basis. A transseptal puncture and access procedure can be performed, including puncturing tissue with the needle followed by immediate advancement of the guidewire into the accessed area, eliminating the need for multiple instrument exchanges during the procedure.

Abstract: A low power voice processing system that includes a plurality of non-audio sensors, at least one microphone system, and a plurality of audio modules, at least some of which can be configured in selected modes. A context determination module is connected to the plurality of audio modules, and further connected to receive input from the plurality of non-audio sensors and the at least one microphone system. The context determination module acts to determine use context for the voice processing system and at least in part selects mode operation of at least some of the plurality of audio modules.

Abstract: A hemostasis device includes a valve, the valve being sized and configured to be disposed entirely within a handle of medical device, the valve including a rim, the rim be sized and configured to seal with a lumen of the handle of the medical device.

Abstract: A powered seat-base release system includes a rod rotatably mounted in a bucket assembly of an aircraft seat and a motor mechanically coupled to the rod. The motor is configured for rotating the rod from a locked position to a released position. A locking mechanism is configured for preventing motion of the bucket assembly. A cable has a first end and a second end, the first end being mechanically coupled to the rod, and the second end being mechanically coupled to the locking mechanism. A user interface is configured to activate the motor for rotating the rod to the released position such that the rod pulls the cable thereby releasing the locking mechanism to enable motion of the bucket assembly. Upon deactivation of the motor, a biasing mechanism is configured to counter rotate the rod from the released position to the locked position thereby back driving the motor.

Abstract: A method for generating a comment capsule for a content segment includes receiving the comment related to the content segment, receiving data associated with the comment, the data including at least one of an identifier for the content segment to which the comment relates, an identifier for a user generating the comment, and a time at which the comment was generated, generating display data for displaying the comment in a comment capsule, and transmitting the display data for displaying the comment capsule in a user interface screen associated with the content segment. The comment capsule is displayed on the user interface screen inline with the content segment, and an appearance of the comment capsule is dynamically changeable based on at least one of a number of comments received for the content segment, a size of the content segment, and a read status of the comment.

Abstract: An inventory system, apparatus and method. The method to be used in a cooler that includes a power module provides power to the inventory system from an electric source, battery, WIFI charge, wireless charge and/or combination thereof, a computer processor coupled to the power module, a memory module coupled to the computer processor, an image capturing module coupled to the processor, a movement module coupled to the processor; wherein the movement module triggers the image capturing device to capture images of products in a cooler due to a movement.

Abstract: A transseptal system includes a needle, a guidewire, a handle, and a dilator. The handle defines a needle passage to slidably receive the needle, and a guidewire passage to slidably receive the guidewire. The dilator defines a lumen having a distal region and a proximal region. The dilator is coupled to the handle such that the lumen is open to the needle passage and the guidewire passage. The proximal region of the lumen is sized to simultaneously receive the needle body and the guidewire. The distal region is sized to slidably receive one of the needle and the guidewire on an individual basis. A transseptal puncture and access procedure can be performed, including puncturing tissue with the needle followed by immediate advancement of the guidewire into the accessed area, eliminating the need for multiple instrument exchanges during the procedure.

Abstract: The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.

Abstract: A system and method for identifying relevant content from other documents and presenting candidate documents/content in a document authoring application is described. A computer-implemented method includes performing an analysis of text of a document being authored by a user with a document authoring application, searching a document library for content elements and documents based on the analysis of the text, identifying candidate documents and candidate content based on the searching, presenting a list of candidate documents or candidate content with the document authoring application, receiving a selection of a candidate document or candidate content from the list in the document authoring application, and including an instance of the selected candidate document or candidate content in the document.

Abstract: Disclosed is an electronics device holder made to be mountable on an aircraft control stick arrangement. The holder enables two dimensions of rotation. Rotation clockwise and counterclockwise is provided by a disk on which the holder is mounted. The disk edges are trapped underneath a containing plate. Friction enables the disk, and thus, the holder to be held in different circular positions. A friction hinge is used to establish and hold different pitch positions for the electronics device.

Abstract: A hemostasis device includes a valve, the valve being sized and configured to be disposed entirely within a handle of a medical device, the valve including a rim, the rim being sized and configured to seal with a lumen of the handle of the medical device.

Abstract: A virtual kiosk system, comprises a memory, and a processor. The processor is configured to identify a user shopping in a retail store, and identify a product category that the user is shopping for in the retail store. The processor is configured to recommend products in the product category to the user. The processor is configured to receive user input from the user on the recommended products that are selected for purchase by the user, add the selected recommended products to a virtual shopping cart, and display the virtual shopping cart to the user so as to allow the user to purchase the selected recommended products.

Abstract: The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.

Abstract: The disclosure relates to modified oncolytic viruses. The modified oncolytic viruses of the disclosure comprise modification in the viral genome encoding exogenous nucleic acids to enhance the oncolytic immunotherapy by remodeling the tumor microenvironment and with enhanced systemic delivery. The disclosure further relates to compositions comprising the modified oncolytic viruses, kits containing the same, and methods of using the oncolytic viruses.