Patents by Inventor Stephen A. Howard

Stephen A. Howard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220362317
    Abstract: The present disclosure provides oncolytic viruses expressing a modulator of interferon regulatory factors (IRFs), and compositions comprising thereof. The present disclosure further provides methods of using said oncolytic viruses and compositions for treating cancer, and for improving a subject's responsiveness to an immunomodulatory agent (e.g., an immune checkpoint inhibitor).
    Type: Application
    Filed: July 21, 2022
    Publication date: November 17, 2022
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Saumendra N. SARKAR, Stephen Howard THORNE
  • Publication number: 20220354623
    Abstract: Provided herein are platforms and methods for mapping a three-dimensional (3D) dental anatomy of a subject.
    Type: Application
    Filed: July 20, 2022
    Publication date: November 10, 2022
    Inventors: Christopher John CIRIELLO, Scott Howard PHILLIPS, James JACKSON, Kenneth MACCALLUM, Nathan John MULLER, Stephen Bruce LOCKE, Ryan Lucas FIELD, Jacob ROSEN
  • Publication number: 20220360858
    Abstract: Systems and methods for a media content user interface. A media content provider includes storage for storing and serving video content to subscribers. The media content provider records and or otherwise stores video content from around the world. Subscribers are provided a user interface to the system that includes a side bar. The side bar includes multiple elements representing different categories of video content. By selecting a given category, available content is filtered according to the selected category and presented. Content which is presented may include live broadcast video for multiple channels on multiple television networks or other content providers. The side bar may further include a collection category specific to a given viewer. Selection of such a category may display video content within the collection. Subcategories in the side bar may be selected for further filtering of available content.
    Type: Application
    Filed: April 25, 2022
    Publication date: November 10, 2022
    Inventors: Gregory N. CHRISTIE, Alessandro SABATELLI, William M. BACHMAN, Imran CHAUDHRI, Jeffrey ROBBIN, Jim YOUNG, Joe HOWARD, Marcel VAN OS, Patrick L. COFFMAN, Stephen O. LEMAY, Jeffrey MA, Lynne KRESS
  • Patent number: 11478518
    Abstract: The present invention relates to oncolytic vaccinia viruses which have been modified to promote anti-tumor immunity and/or reduce host immunity and/or antibody response against the virus. It is based, at least in part, on the discovery that oncolytic vaccinia virus (i) bearing a genome deletion of a gene that reduces T cell immunity (interleukin-18 binding protein); (ii) treated with a sialidase enzyme which is believed to reduce TLR2 activation and therefore the antibody response; (iii) carrying a gene that enhances cytotoxic T lymphocyte induction (e.g., TRIF) and/or (iv) reduces tumor myeloid-derived suppressor cells by reducing prostaglandin E2 reduces tumor growth. Accordingly, the present invention provides for immunooncolytic vaccinia viruses and methods of using them in the treatment of cancers.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: October 25, 2022
    Assignee: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Stephen Howard Thorne
  • Publication number: 20220337914
    Abstract: Systems and methods for a media content user interface. A media content provider includes storage for storing and serving video content to subscribers. The media content provider records and or otherwise stores video content from around the world. Subscribers are provided a user interface to the system that includes a side bar. The user interface provides context sensitive hints to assist the viewer. The system also tracks a viewer's viewing history in a manner that allows the viewer to review and directly access any part of that history. Finally, magnetic points are created for use during video scrubbing to intelligently select relocation points for the current playback position.
    Type: Application
    Filed: April 4, 2022
    Publication date: October 20, 2022
    Inventors: Gregory N. CHRISTIE, Alessandro SABATELLI, William M. BACHMAN, Imran CHAUDHRI, Jeffrey ROBBIN, Jim YOUNG, Joe HOWARD, Marcel VAN OS, Patrick L. COFFMAN, Stephen O. LEMAY, Jeffrey MA, Lynne KRESS
  • Publication number: 20220332201
    Abstract: An electric vehicle charging cable includes power charging wire(s) to carry power between an electric vehicle supply equipment (EVSE) and an electric vehicle (EV), signal wire(s) to carry signaling data relating to charging the EV, a charging cable connector to connect the power charging wire(s) and the signal wire(s) to an inlet of the EV, and a charging protocol controller. The charging protocol controller includes a first connector to terminate the signal wire(s), a second connector to terminate supply voltage and communication from the EVSE, one or more communication circuit(s), and a processor that performs signal handshake and control and communication between the EVSE and the charging protocol controller.
    Type: Application
    Filed: April 14, 2021
    Publication date: October 20, 2022
    Inventors: Robert Mitri Khamashta, Carl Fredrick Hagenmaier, JR., Charles Hardin, Joseph Howard, Craig Toshiro Matsuno, Stephen Eric Sidle
  • Patent number: 11475442
    Abstract: The present invention generally relates to a method, system and program product for modifying a supply of stable value digital asset tokens tied to a blockchain.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: October 18, 2022
    Assignee: Gemini IP, LLC
    Inventors: Daniel William Halley James, Cameron Howard Winklevoss, Tyler Howard Winklevoss, Brandon Arvanaghi, Eric Neiman Winer, Stephen Judkins, Alex Parkinson
  • Patent number: 11472558
    Abstract: A seat base includes a plurality of linear actuators each having a first end pivotally mounted to a base member and a second end pivotally mounted to a seat member. A controller is adapted for controlling an extension length of each of the plurality of linear actuators in a coordinated manner for adjusting a position of the seat member with six degrees-of-freedom and for damping vibration of the seat member. An active vibration mitigation method for reducing vibrations of an aircraft seat includes receiving vibration data from one or more accelerometers mounted to the aircraft seat and determining a vibration profile based on the vibration data. When vibration mitigation is warranted, control signals for damping vibration are determined and transmitted to a plurality of linear actuators adapted to support the aircraft seat.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: October 18, 2022
    Assignee: Textron Innovations, Inc.
    Inventors: Stephen Howard Fagan, Paul Stokholm Warren, Emily O'Kelley Pearson, Jeremy Joseph Kneuper, Phillip Kendrick
  • Publication number: 20220329891
    Abstract: Systems and methods for a media content delivery service. A media content provider includes a data store for storing and serving media content to subscribers. The media content provider continually records and or otherwise stores video and audio content from around the world. Stored content will generally correspond to a large number of other media content providers, such as cable television operators, Internet based media content providers, television networks, and so on. Subscribers to the media provider interact with the media content provider via hardware and/or software mechanisms either provided by the media content provider or conforming to specifications of the media content provider. Based on these subscriber's subscriptions to the other content providers, the subscribers will have viewing, listening, or application execution privileges for content maintained in the data store. Content of a subscriber corresponding to multiple video content providers is maintained and served by a single provider.
    Type: Application
    Filed: March 25, 2022
    Publication date: October 13, 2022
    Inventors: Gregory N. CHRISTIE, Alessandro SABATELLI, William M. BACHMAN, Imran CHAUDHRI, Jeffrey ROBBIN, Jim YOUNG, Joe HOWARD, Marcel VAN OS, Patrick L. COFFMAN, Stephen O. LEMAY, Jeffrey MA, Lynne KRESS
  • Publication number: 20220315225
    Abstract: A seat base includes a plurality of linear actuators each having a first end pivotally mounted to a base member and a second end pivotally mounted to a seat member. A controller is adapted for controlling an extension length of each of the plurality of linear actuators in a coordinated manner for adjusting a position of the seat member with six degrees-of-freedom and for damping vibration of the seat member. An active vibration mitigation method for reducing vibrations of an aircraft seat includes receiving vibration data from one or more accelerometers mounted to the aircraft seat and determining a vibration profile based on the vibration data. When vibration mitigation is warranted, control signals for damping vibration are determined and transmitted to a plurality of linear actuators adapted to support the aircraft seat.
    Type: Application
    Filed: June 9, 2022
    Publication date: October 6, 2022
    Inventors: Stephen Howard Fagan, Paul Stokholm Warren, Emily O'Kelley Pearson, Jeremy Joseph Kneuper, Phillip Kendrick
  • Publication number: 20220321940
    Abstract: Systems and methods for a media content system. A media content provider includes storage for storing and serving video content to subscribers. The media content provider records and or otherwise stores video content from around the world. Subscribers are provided a user interface that provides context sensitive hints to assist the viewer. The system further enables viewers skip, view, and interact with advertisements.
    Type: Application
    Filed: February 18, 2022
    Publication date: October 6, 2022
    Inventors: Gregory N. CHRISTIE, Alessandro SABATELLI, William M. BACHMAN, Imran CHAUDHRI, Jeffrey ROBBIN, Jim YOUNG, Joe HOWARD, Marcel VAN OS, Patrick L. COFFMAN, Stephen O. LEMAY, Jeffrey MA, Lynne KRESS
  • Publication number: 20220289845
    Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.
    Type: Application
    Filed: May 2, 2022
    Publication date: September 15, 2022
    Inventors: Stephen Willingham, Maureen Howard, Jie Liu, Ravindra Majeti, Susan Sweeney Prohaska, Anne Kathrin Volkmer, Jens-Peter Volkmer, Irving L. Weissman
  • Publication number: 20220257226
    Abstract: A transseptal system includes a needle, a guidewire, a handle, and a dilator. The handle defines a needle passage to slidably receive the needle, and a guidewire passage to slidably receive the guidewire. The dilator defines a lumen having a distal region and a proximal region. The dilator is coupled to the handle such that the lumen is open to the needle passage and the guidewire passage. The proximal region of the lumen is sized to simultaneously receive the needle body and the guidewire. The distal region is sized to slidably receive one of the needle and the guidewire on an individual basis. A transseptal puncture and access procedure can be performed, including puncturing tissue with the needle followed by immediate advancement of the guidewire into the accessed area, eliminating the need for multiple instrument exchanges during the procedure.
    Type: Application
    Filed: December 17, 2021
    Publication date: August 18, 2022
    Applicant: MEDTRONIC, INC.
    Inventors: Stephen A. Howard, Kevin A. Knutsen
  • Publication number: 20220253842
    Abstract: The present invention generally relates to a method, system and program product for modifying a supply of stable value digital asset tokens tied to a blockchain.
    Type: Application
    Filed: April 26, 2022
    Publication date: August 11, 2022
    Inventors: Daniel William Halley James, Tyler Howard Winklevoss, Cameron Howard Winklevoss, Brandon Arvanaghi, Stephen Judkins, Alex Parkinson, Eric Neiman Winer
  • Publication number: 20220251199
    Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.
    Type: Application
    Filed: May 2, 2022
    Publication date: August 11, 2022
    Inventors: Stephen Willingham, Maureen Howard, Jie Liu, Ravindra Majeti, Susan Sweeney Prohaska, Anne K. Volkmer, Jens-Peter Volkmer, Irving L. Weissman
  • Publication number: 20220247984
    Abstract: An interactive projection system and method comprising a camera/projector unit having a computer processor connected via a network to a content server and content database. The system projects interactive trigger areas on a three-dimensional object. Specific content stored on the content server or locally in the memory of the computer processor is associated with each trigger area. A user interacts with the trigger areas and the system projects informational or entertainment content about the object on the surface of the object.
    Type: Application
    Filed: January 24, 2022
    Publication date: August 4, 2022
    Applicant: Omni Consumer Products, LLC
    Inventor: Stephen Howard
  • Publication number: 20220243900
    Abstract: A light fixture having an upper housing and a lower housing. A rotate-tilt mechanism is interposed between the two housings to permit the lower housing both to rotate and tilt relative to the upper housing.
    Type: Application
    Filed: February 4, 2021
    Publication date: August 4, 2022
    Inventors: Gautham Raj Kemparaju, Stephen Howard Clark, Douglas Dewayne Grove
  • Patent number: 11402017
    Abstract: A vehicle includes an engine and a transmission having an input shaft operably coupled to the engine, an output shaft operably coupled to wheels of the vehicle, a primary pump, and a secondary pump. The primary and secondary pumps are each configured to supply pressurized fluid to a valve body of the transmission. A controller is programmed to, in response to a loss of pressure of the primary pump and a speed of the output shaft exceeding a first threshold, shift the transmission to a neutral state, energize the secondary pump once the transmission is in the neutral state, and command the engine to idle speed.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: August 2, 2022
    Assignee: Ford Global Technologies, LLC
    Inventors: Richard Reynolds Hathaway, Edward Katynski, Jerry Lee Aeschliman, Jr., David Gilewski, Stephen John Bettley, Kurt Howard Nickerson, Robert E. Meyer
  • Publication number: 20220237374
    Abstract: A system and method for identifying relevant content from other documents and presenting candidate documents/content in a document authoring application is described. A computer-implemented method includes performing an analysis of text of a document being authored by a user with a document authoring application, searching a document library for content elements and documents based on the analysis of the text, identifying candidate documents and candidate content based on the searching, presenting a list of candidate documents or candidate content with the document authoring application, receiving a selection of a candidate document or candidate content from the list in the document authoring application, and including an instance of the selected candidate document or candidate content in the document.
    Type: Application
    Filed: March 26, 2021
    Publication date: July 28, 2022
    Inventors: Benjamin Gustav WILDE, Ransom Lloyd RICHARDSON, Richard Malcolm BANKS, Manoj SHARMA, Zeyu WU, Matthew Stephen HOWARD, Sudarshan SUNDAR, Lyndsy Marie STOPA, Yi ZHENG, Jacob Lee SANCHEZ, Aleksandr POLYAKOV, Jason Peter CAMPOLI, Gregory Alan HOWARD, Paul Anthony SCUDIERI
  • Publication number: 20220226636
    Abstract: Implantable apparatus includes two or more alignable marker elements, and systems and methods for manufacturing such implantable apparatus, and methods to utilize such implantable apparatus. For example, the implantable apparatus may include a first alignable marker element and a second alignable marker element that may be used to ensure proper alignment with a target site.
    Type: Application
    Filed: January 19, 2022
    Publication date: July 21, 2022
    Inventors: Jay T. Rassat, Varun Bhatia, Kendall Emfield, Ryan Lahm, Alan Cheng, Douglas S. Hine, Kristin M. Johnson, Gregory N. Nesseth, Jonathan E. Baxter, Daniel W. Celotta, Stephen A. Howard, Nathan A. Grenz, Brian P. Colin, Ronald A. Drake, Juan Meng, Hongyang Lu