Abstract: An inventory system, apparatus and method. The method to be used in a cooler that includes a power module provides power to the inventory system from an electric source, battery, WIFI charge, wireless charge and/or combination thereof, a computer processor coupled to the power module, a memory module coupled to the computer processor, an image capturing module coupled to the processor, a movement module coupled to the processor; wherein the movement module triggers the image capturing device to capture images of products in a cooler due to a movement.

Abstract: This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.

Abstract: The present disclosure provides for compositions comprising nucleic acids encoding for fusion proteins of the Tumor Necrosis Factor Super Family Ligands fused to oligomerization domains. Further provided are viral and non-viral vectors for delivery of such compositions. The present disclosure also provides for compositions comprising fusion proteins of the Tumor Necrosis Factor Super Family Ligands fused to oligomerization domains.

Abstract: The disclosure relates to modified oncolytic viruses. The modified oncolytic viruses of the disclosure comprise modification in the viral genome encoding exogenous nucleic acids to enhance the oncolytic immunotherapy by remodeling the tumor microenvironment and with enhanced systemic delivery. The disclosure further relates to compositions comprising the modified oncolytic viruses, kits containing the same, and methods of using the oncolytic viruses.

Abstract: A curved screen skylight for an aircraft includes a curved display screen which is configured to display imagery provided from a camera positioned on the aircraft or preloaded imagery stored on a memory storage device. The curved screen display conforms to an aircraft overhead panel and can be secured using flanges extending from the overhead panel.

Abstract: The present disclosure provides an anode assembly for a battery cell. The battery cell comprises a separator layer, an anode layer, an anode current collector, and a seal. The anode layer is at least partially disposed on the separator layer and has a first surface facing the separator layer, a second surface facing away from the separator layer, and an outer surface extending from the first surface to the second surface. The anode layer comprises a solid-state electrolyte (SSE) having pores. The anode current collector is coupled to the second surface of the anode layer. The seal is substantially impervious to liquid. The present disclosure also provides methods of forming an anode assembly for a battery cell.

Abstract: The disclosure relates to modified oncolytic viruses. The modified oncolytic viruses of the disclosure comprise modification in the viral genome encoding exogenous nucleic acids to enhance the oncolytic immunotherapy by remodeling the tumor microenvironment and with enhanced systemic delivery. The disclosure further relates to compositions comprising the modified oncolytic viruses, kits containing the same, and methods of using the oncolytic viruses.

Abstract: A method of modifying a virus for in vivo delivery to a region of interest includes forming an enveloping composition including a lipid conjugate formed by conjugating at least one lipid with at least one hydrophilic compound via a linkage which is cleavable under conditions present in the region of interest and combining the virus with the enveloping composition to encompass the virus within the enveloping structure.

Abstract: An interactive projection system and method comprising a camera/projector unit having a computer processor connected via a network to a content server and content database. The system projects interactive trigger areas on a three-dimensional object. Specific content stored on the content server or locally in the memory of the computer processor is associated with each trigger area. A user interacts with the trigger areas and the system projects informational or entertainment content about the object on the surface of the object.

Abstract: An includes a soil-sensing arrangement. The apparatus (1) includes a seed-delivery mechanism. The soil-sensing arrangement includes one or more soil-sensing elements. Each of the one or more soil-sensing elements senses one or more conditions of the soil. The one or more soil-sensing elements can take the form of one or more soil-sensing tines (19). In the method, material is delivered to a locally-optimised soil depth LOD. In the method, there is at least periodic sensing of one or more conditions of the soil, and at two or more depths at mutually differing proximities to the locally-optimised depth.

Abstract: The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.

Abstract: The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.

Abstract: Devices, systems, and methods for quantifying applied pressure by a device against an area of tissue. In particular, the present technology is related to medical devices including an optical element with a fiber Bragg grating, systems including the medical devices, and methods of quantifying applied pressure by the medical device. In one embodiment, a medical device comprises an elongate body including a distal portion and a proximal portion opposite the distal portion, and an optical element located at the distal portion of the elongate body. In one embodiment, the optical element include an optical fiber with a fiber Bragg grating. In one embodiment, the medical device is part of a medical system comprising a control unit in communication with the medical device, the control unit including an optical interrogator in communication with the optical element and processing circuitry configured to receive data from the optical interrogator.

Abstract: A method and system for creating permanent lesions in an area of target tissue, such as tissue at or proximate a junction between a pulmonary vein and the left atrium. The method may generally include positioning a medical device in contact with a pulmonary vein ostium, ablating the tissue, and recording a plurality of temperature measurements from one or more of three temperature sensors. The device may include an occlusion element in communication with a coolant source, a first sensor located distal of the occlusion element, a second sensor located proximal of the occlusion element, and a third sensor located in the occlusion element. One or more temperature measurements may be compared with each other to assess occlusion of the pulmonary vein, and/or may be compared with a set of reference temperatures to predict a real-time temperature within the target tissue.

Abstract: A system for delivering respiratory therapy to a patient includes a patient interface device for delivering pressurized gas to a patient, a connector system for connection to a source of pressurized gas and a conduit system fluidly connecting the connector system to the patient interface device. The connector system includes a plurality of closable ports that allow a plurality of different modes of respiratory therapy to be provided. The conduit system may include a first gas line, a second gas line and a third gas line. The second gas line and third gas line may be contained within the first gas line along at least part of their length.

Abstract: A system for delivering respiratory therapy to a patient includes a patient interface device for delivering pressurized gas to a patient, a connector system for connection to a source of pressurized gas and a conduit system fluidly connecting the connector system to the patient interface device. The connector system includes a plurality of closable ports that allow a plurality of different modes of respiratory therapy to be provided. The conduit system may include a first gas line, a second gas line and a third gas line. The second gas line and third gas line may be contained within the first gas line along at least part of their length.

Abstract: The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.

Abstract: Devices, systems, and methods for quantifying applied pressure by a device against an area of tissue. In particular, the present technology is related to medical devices including an optical element with a fiber Bragg grating, systems including the medical devices, and methods of quantifying applied pressure by the medical device. In one embodiment, a medical device comprises an elongate body including a distal portion and a proximal portion opposite the distal portion, and an optical element located at the distal portion of the elongate body. In one embodiment, the optical element include an optical fiber with a fiber Bragg grating. In one embodiment, the medical device is part of a medical system comprising a control unit in communication with the medical device, the control unit including an optical interrogator in communication with the optical element and processing circuitry configured to receive data from the optical interrogator.

Abstract: The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.