Abstract: A price monitoring system includes a memory and a processor configured to: determine, by the price monitoring system, an identity of a determined product positioned a particular location based on image information regarding the determined product, compare, by the price monitoring system, the identity of the determined product positioned at the particular location to an identity of an assigned product assigned to that particular location, determine, based on the comparison, that the identity of the determined product positioned at the particular location does not match the identity of the assigned product assigned to that particular location, retrieve product information for the determined product positioned at the particular location from a product database, transmit instructions configured to command an electronic product label at the particular location to display the product information for the determined product positioned at the particular location.

Abstract: A seat base includes a plurality of linear actuators each having a first end pivotally mounted to a base member and a second end pivotally mounted to a seat member. A controller is adapted for controlling an extension length of each of the plurality of linear actuators in a coordinated manner for adjusting a position of the seat member with six degrees-of-freedom and for damping vibration of the seat member. An active vibration mitigation method for reducing vibrations of an aircraft seat includes receiving vibration data from one or more accelerometers mounted to the aircraft seat and determining a vibration profile based on the vibration data. When vibration mitigation is warranted, control signals for damping vibration are determined and transmitted to a plurality of linear actuators adapted to support the aircraft seat.

Abstract: A method for generating a comment capsule for a content segment includes receiving the comment related to the content segment, receiving data associated with the comment, the data including at least one of an identifier for the content segment to which the comment relates, an identifier for a user generating the comment, and a time at which the comment was generated, generating display data for displaying the comment in a comment capsule, and transmitting the display data for displaying the comment capsule in a user interface screen associated with the content segment. The comment capsule is displayed on the user interface screen inline with the content segment, and an appearance of the comment capsule is dynamically changeable based on at least one of a number of comments received for the content segment, a size of the content segment, and a read status of the comment.

Abstract: The present invention relates to oncolytic vaccinia viruses which have been modified to promote anti-tumor immunity and/or reduce host immunity and/or antibody response against the virus. It is based, at least in part, on the discovery that oncolytic vaccinia virus (i) bearing a genome deletion of a gene that reduces T cell immunity (interleukin-18 binding protein); (ii) treated with a sialidase enzyme which is believed to reduce TLR2 activation and therefore the antibody response; (iii) carrying a gene that enhances cytotoxic T lymphocyte induction (e.g., TRIF) and/or (iv) reduces tumor myeloid-derived suppressor cells by reducing prostaglandin E2 reduces tumor growth. Accordingly, the present invention provides for immunooncolytic vaccinia viruses and methods of using them in the treatment of cancers.

Abstract: A light fixture having an upper housing and a lower housing. A rotate-tilt mechanism is interposed between the two housings to permit the lower housing both to rotate and tilt relative to the upper housing.

Abstract: The present disclosure provides oncolytic viruses expressing a modulator of interferon regulatory factors (IRFs), and compositions comprising thereof. The present disclosure further provides methods of using said oncolytic viruses and compositions for treating cancer, and for improving a subject's responsiveness to an immunomodulatory agent (e.g., an immune checkpoint inhibitor).

Abstract: The present invention relates to oncolytic vaccinia viruses which have been modified to promote anti-tumor immunity and/or reduce host immunity and/or antibody response against the virus. It is based, at least in part, on the discovery that oncolytic vaccinia virus (i) bearing a genome deletion of a gene that reduces T cell immunity (interleukin-18 binding protein); (ii) treated with a sialidase enzyme which is believed to reduce TLR2 activation and therefore the antibody response; (iii) carrying a gene that enhances cytotoxic T lymphocyte induction (e.g., TRIF) and/or (iv) reduces tumor myeloid-derived suppressor cells by reducing prostaglandin E2 reduces tumor growth. Accordingly, the present invention provides for immunooncolytic vaccinia viruses and methods of using them in the treatment of cancers.

Abstract: A seat base includes a plurality of linear actuators each having a first end pivotally mounted to a base member and a second end pivotally mounted to a seat member. A controller is adapted for controlling an extension length of each of the plurality of linear actuators in a coordinated manner for adjusting a position of the seat member with six degrees-of-freedom and for damping vibration of the seat member. An active vibration mitigation method for reducing vibrations of an aircraft seat includes receiving vibration data from one or more accelerometers mounted to the aircraft seat and determining a vibration profile based on the vibration data. When vibration mitigation is warranted, control signals for damping vibration are determined and transmitted to a plurality of linear actuators adapted to support the aircraft seat.

Abstract: A seat base includes a plurality of linear actuators each having a first end pivotally mounted to a base member and a second end pivotally mounted to a seat member. A controller is adapted for controlling an extension length of each of the plurality of linear actuators in a coordinated manner for adjusting a position of the seat member with six degrees-of-freedom and for damping vibration of the seat member. An active vibration mitigation method for reducing vibrations of an aircraft seat includes receiving vibration data from one or more accelerometers mounted to the aircraft seat and determining a vibration profile based on the vibration data. When vibration mitigation is warranted, control signals for damping vibration are determined and transmitted to a plurality of linear actuators adapted to support the aircraft seat.

Abstract: A transseptal system includes a needle, a guidewire, a handle, and a dilator. The handle defines a needle passage to slidably receive the needle, and a guidewire passage to slidably receive the guidewire. The dilator defines a lumen having a distal region and a proximal region. The dilator is coupled to the handle such that the lumen is open to the needle passage and the guidewire passage. The proximal region of the lumen is sized to simultaneously receive the needle body and the guidewire. The distal region is sized to slidably receive one of the needle and the guidewire on an individual basis. A transseptal puncture and access procedure can be performed, including puncturing tissue with the needle followed by immediate advancement of the guidewire into the accessed area, eliminating the need for multiple instrument exchanges during the procedure.

Abstract: An interactive projection system and method comprising a camera/projector unit having a computer processor connected via a network to a content server and content database. The system projects interactive trigger areas on a three-dimensional object. Specific content stored on the content server or locally in the memory of the computer processor is associated with each trigger area. A user interacts with the trigger areas and the system projects informational or entertainment content about the object on the surface of the object.

Abstract: A light fixture having an upper housing and a lower housing. A rotate-tilt mechanism is interposed between the two housings to permit the lower housing both to rotate and tilt relative to the upper housing.

Abstract: A system and method for identifying relevant content from other documents and presenting candidate documents/content in a document authoring application is described. A computer-implemented method includes performing an analysis of text of a document being authored by a user with a document authoring application, searching a document library for content elements and documents based on the analysis of the text, identifying candidate documents and candidate content based on the searching, presenting a list of candidate documents or candidate content with the document authoring application, receiving a selection of a candidate document or candidate content from the list in the document authoring application, and including an instance of the selected candidate document or candidate content in the document.

Abstract: Implantable apparatus includes two or more alignable marker elements, and systems and methods for manufacturing such implantable apparatus, and methods to utilize such implantable apparatus. For example, the implantable apparatus may include a first alignable marker element and a second alignable marker element that may be used to ensure proper alignment with a target site.

Abstract: This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.

Abstract: This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.

Abstract: A powered seat-base release system includes a rod rotatably mounted in a bucket assembly of an aircraft seat and a motor mechanically coupled to the rod. The motor is configured for rotating the rod from a locked position to a released position. A locking mechanism is configured for preventing motion of the bucket assembly. A cable has a first end and a second end, the first end being mechanically coupled to the rod, and the second end being mechanically coupled to the locking mechanism. A user interface is configured to activate the motor for rotating the rod to the released position such that the rod pulls the cable thereby releasing the locking mechanism to enable motion of the bucket assembly. Upon deactivation of the motor, a biasing mechanism is configured to counter rotate the rod from the released position to the locked position thereby back driving the motor.

Abstract: A method and system for creating permanent lesions in an area of target tissue, such as tissue at or proximate a junction between a pulmonary vein and the left atrium. The method may generally include positioning a medical device in contact with a pulmonary vein ostium, ablating the tissue, and recording a plurality of temperature measurements from one or more of three temperature sensors. The device may include an occlusion element in communication with a coolant source, a first sensor located distal of the occlusion element, a second sensor located proximal of the occlusion element, and a third sensor located in the occlusion element. One or more temperature measurements may be compared with each other to assess occlusion of the pulmonary vein, and/or may be compared with a set of reference temperatures to predict a real-time temperature within the target tissue.

Abstract: This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.

Abstract: An apparatus (1) and method are disclosed for seeding soil. The apparatus (1) comprises a soil-sensing arrangement. The apparatus (1) comprises a seed-delivery mechanism. The soil-sensing arrangement comprises one or more soil-sensing elements. Each of the one or more soil-sensing elements is configured to sense one or more conditions of the soil. The one or more soil-sensing elements can take the form of one or more soil-sensing tines 19. In the method, material is delivered to a locally-optimised soil depth LOD. In the method, there is at least periodic sensing of one or more conditions of the soil, and at two or more depths at mutually differing proximities to the locally-optimised depth.