Abstract: Disclosed are compositions relating to novopeptides identified by the presence of framshift mutations in tumor genes previously not identified as being oncogenic. The disclosed peptides can be used in the disclosed methods for the treatment of cancer.

Abstract: A cut-point in the quantitative measurement of PTEN protein expression that accurately identifies tumors with two inactivated alleles of the PTEN gene. Patients with a normalized PTEN score of PTEN null will be treated with a pan-ErbB tyrosine kinase inhibitor. A normalized PTEN protein expression score is obtained by comparing the tumor PTEN OD expression value with the non-malignant PTEN OD expression value.

Abstract: The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.

Abstract: The present application provides synbodies against AKT1 differing in amino acid sequence, conjugation chemistry, linker/scaffold, or adjunct moiety. The synbodies are useful for diagnosis and treatment of cancer and as research reagents.

Abstract: The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.

Abstract: Methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.

Abstract: The present invention provides methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.

Abstract: Anchorage devices are disclosed for use in an anchorage system, especially for vehicle seats, using a floor track having a longitudinal channel whose opening has opposed lips with a series of periodic circular cut-outs. The anchorage device has enlarged slidable feet (104) which are insertable into the opening of the track channel at the cut-outs, and when slid along are held captive beneath the lips of the track. A releasable locking mechanism is provided for locking the device longitudinally to the track, so that the feet (104) can be held in the captive position. Preferably the device has an elongate body, with the locking mechanism operated by a lever at one end. The top surfaces (143) of at least some of the feet (104) are longitudinally inclined relative to the longitudinal direction. When slid to the captive position they come into contact or near contact with the underside of the track lips, reducing or preventing rattle relative to the track.

Abstract: A releasable anchorage device for securing seats to tracks in vehicle floors has an elongate body with a fixed, non-slidable downward protrusion at its front end, an actuating lever at its rear end, and sets of slidable securing feet movable relative to the protrusion by the lever operating via an actuating mechanism. The mechanism includes an elongate drive rod connecting the lever to a middle set or front set of the feet which have an anti-rattle mechanism to grip the track, such as by longitudinally-inclined upper surfaces thereon. A rear set of feet may also be slidable and can move together with the middle feet. The lever is easily accessible, being at the rear end, but operates to provide an anti-rattle engagement with the track at an intermediate point along the device, spaced from the rear end, where the prevention of rattling is particularly needed.

Abstract: The present invention provides methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.

Abstract: A method for use in forming a molded part includes providing a mold having a cavity and a movable pin, injecting a moldable material into the cavity, biasing the movable pin to maintain an end of the movable pin in contact with the moldable material in the cavity during the curing of the moldable material and until the moldable material is cured, and monitoring movement of the biased movable pin during curing of the moldable material in the mold. Also disclosed is a sensor engageable with an end of a movable pin of a mold for monitoring the forming of a moldable part, and systems employing the same.

Abstract: The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.

Abstract: The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.

Abstract: The present invention relates to the identification and selection of attachment molecules that attach/immobilize an entity having a detectable activity or property on a support in an orientation that provides a detectable activity or property, and to surfaces made of the attachment molecules.

Abstract: A system for pulp bale wrapping includes at least one press plate operable to press a wrapper into a pulp bale. A method for wrapping pulp bale includes disposing the pulp bale between an upper wrapper and a lower wrapper, wrapping the pulp bale in the upper wrapper and the lower wrapper, and maintaining at least one of the upper wrapper and the lower wrapper in a wrapped position by crushing the at least one wrapper into the wrapped pulp bale.

Abstract: Disclosed are compositions relating to novopeptides identified by the presence of frameshift mutations in tumor genes previously not identified as being oncogenic. The disclosed peptides can be used in the disclosed methods for the treatment of cancer.

Abstract: A removable card for use with a mobile wireless communication device has a processor and a non-volatile memory, connected to the processor. The memory has programming code stored configured to be executed by the processor and is operable in one of two modes. In a first mode the card is connected to the device with the card storing information received wirelessly by the device from the Internet. In a second mode the card is connected to a network portal device, which is connected to the Internet, with the card storing information received through the network portal device from the Internet. In another embodiment, the removable card has electrical connections for connecting to a mobile wireless communicating device for use by a user to connect to the Internet. The memory has two portions: a first portion and a second portion with the partitioning being alterable. The processor restricts access to the first portion by the user, while grants access to the second portion to the user.

Abstract: The invention generally concerns compositions and methods for genetic vaccination with amyloid beta (A?) protein. Such vaccines may provide effective treatment for neurodegenerative disease such as Alzheimer's disease. Vaccination methods are can be used to induce a Th2 type immune response directed to A?. This immune response id shown to substantially reduce A? concentration and A? plaque size in an Alzheimer's model system.

Abstract: A method of transferring a gene to vertebrate cells is disclosed. The method comprises the steps of: (a) providing microprojectiles, the microprojectiles carrying polynucleic acid sequences, the sequences comprising, in the 5? to 3? direction, a regulatory sequence operable in the tissue cells and a gene positioned downstream of the regulatory sequence and under the transcriptional control thereof; and (b) accelerating the microprojectiles at the cells, with the microprojectiles contacting the cells at a speed sufficient to penetrate the cells and deposit the polynucleic acid sequences therein. Preferably, the target cells reside in situ in the animal subject when they are transformed. Preferred target cells are dermis or hypodermis cells, and preferred genes for insertion into the target cells are genes which code for proteins or peptides which produce a physiological response in the animal subject.

Abstract: A method of transferring a gene to vertebrate cells is disclosed. The method comprises the steps of: (a) providing microprojectiles, the microprojectiles carrying polynucleic acid sequences, the sequences comprising, in the 5? to 3? direction, a regulatory sequence operable in the tissue cells and a gene positioned downstream of the regulatory sequence and under the transcriptional control thereof; and (b) accelerating the microprojectiles at the cells, with the microprojectiles contacting the cells at a speed sufficient to penetrate the cells and deposit the polynucleic acid sequences therein. Preferably, the target cells reside in situ in the animal subject when they are transformed. Preferred target cells are dermis or hypodermis cells, and preferred genes for insertion into the target cells are genes which code for proteins or peptides which produce a physiological response in the animal subject.