Patents by Inventor Stephen A. Judice

Stephen A. Judice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolated oligonucleotides containing modified nucleotides
    Patent number: 11866773
    Abstract: Described and featured herein are isolated oligonucleotides containing, from 5? to 3?, a nicking enzyme recognition sequence, at least 9 nucleotides that specifically bind a target nucleic acid molecule, and 2? modified nucleotides. The isolated oligonucleotides may be used in compositions and methods for quantifying detection of a target oligonucleotide in a sample in real time. These methods are compatible with target oligonucleotides amplified using a Nicking and Extension Amplification Reaction (NEAR) reaction.
    Type: Grant
    Filed: November 15, 2021
    Date of Patent: January 9, 2024
    Assignee: ENVIROLOGIX INC.
    Inventors: Daniel Shaffer, Stephen A. Judice
  • COMPOSITIONS AND METHODS FOR ENHANCING AND/OR PREDICTING DNA AMPLIFICATION
    Publication number: 20230220495
    Abstract: The present invention features compositions and methods for amplifying a target oligonucleotide in a sample, including detection of the target oligonucleotide in real time.
    Type: Application
    Filed: October 6, 2022
    Publication date: July 13, 2023
    Applicant: ENVIROLOGIX INC.
    Inventors: Lars PETERS, Stephen A. JUDICE, Daniel SHAFFER, Breck PARKER
  • Compositions and methods for enhancing and/or predicting DNA amplification
    Patent number: 11505836
    Abstract: The present invention features compositions and methods for amplifying a target oligonucleotide in a sample, including detection of the target oligonucleotide in real time.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: November 22, 2022
    Assignee: ENVIROLOGIX INC.
    Inventors: Lars Peters, Stephen A. Judice, Daniel Shaffer, Breck Parker
  • Compositions and methods for quantifying a nucleic acid sequence in a sample
    Patent number: 11427863
    Abstract: The present invention features compositions and methods for quantifying detection of a target oligonucleotide in a sample in real time. These methods are compatible with target oligonucleotides amplified using a NEAR reaction.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: August 30, 2022
    Assignee: Envirologix Inc.
    Inventor: Stephen A. Judice
  • COMPOSITIONS AND METHODS FOR QUANTIFYING A NUCLEIC ACID SEQUENCE IN A SAMPLE
    Publication number: 20220243262
    Abstract: The present invention features compositions and methods for quantifying detection of a target oligonucleotide in a sample in real time. These methods are compatible with target oligonucleotides amplified using a NEAR reaction.
    Type: Application
    Filed: November 15, 2021
    Publication date: August 4, 2022
    Applicant: ENVIROLOGIX INC.
    Inventors: Daniel Shaffer, Stephen A. Judice
  • Compositions and methods for detecting nicking enzyme and polymerase activity using a substrate molecule
    Patent number: 11220708
    Abstract: The present invention provides compositions and methods for assaying the activity of nicking enzyme and polymerase in a reaction involving the use of a nucleic acid substrate molecule that detects nicking enzyme and polymerase extension activities by the release of a detectable reporter (e.g., a fluorophore).
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: January 11, 2022
    Assignee: ENVIROLOGIX INC.
    Inventor: Stephen A. Judice
  • Compositions and methods for quantifying a nucleic acid sequence in a sample
    Patent number: 11208687
    Abstract: The present invention features compositions and methods for quantifying detection of a target oligonucleotide in a sample in real time. These methods are compatible with target oligonucleotides amplified using a NEAR reaction.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: December 28, 2021
    Assignee: ENVIROLOGIX INC.
    Inventors: Daniel Shaffer, Stephen A. Judice
  • COMPOSITIONS AND METHODS FOR DETECTING AN RNA VIRUS
    Publication number: 20210025016
    Abstract: The present invention provides methods for rapidly identifying an RNA viral infection using an isothermal nucleic acid amplification reaction that can be carried out extracted RNA in the context of a crude biological sample.
    Type: Application
    Filed: August 12, 2020
    Publication date: January 28, 2021
    Applicant: ENVIROLOGIX INC.
    Inventors: LARS PETERS, STEPHEN A. JUDICE, DANIEL SHAFFER, BRECK PARKER
  • Compositions and methods for detecting an RNA virus
    Patent number: 10793922
    Abstract: The present invention provides methods for rapidly identifying an RNA viral infection using an isothermal nucleic acid amplification reaction that can be carried out extracted RNA in the context of a crude biological sample.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: October 6, 2020
    Assignee: ENVIROLOGIX INC.
    Inventors: Lars Peters, Stephen A. Judice, Daniel Shaffer, Breck Parker
  • COMPOSITIONS AND METHODS FOR QUANTIFYING A NUCLEIC ACID SEQUENCE IN A SAMPLE
    Publication number: 20200239947
    Abstract: The present invention features compositions and methods for quantifying detection of a target oligonucleotide in a sample in real time. These methods are compatible with target oligonucleotides amplified using a NEAR reaction.
    Type: Application
    Filed: February 5, 2020
    Publication date: July 30, 2020
    Applicant: ENVIROLOGIX INC.
    Inventors: DANIEL SHAFFER, STEPHEN A. JUDICE
  • COMPOSITIONS AND METHODS FOR DETECTING NICKING ENZYME AND POLYMERASE ACTIVITY USING A SUBSTRATE MOLECULE
    Publication number: 20200157612
    Abstract: The present invention provides compositions and methods for assaying the activity of nicking enzyme and polymerase in a reaction involving the use of a nucleic acid substrate molecule that detects nicking enzyme and polymerase extension activities by the release of a detectable reporter (e.g., a fluorophore).
    Type: Application
    Filed: February 5, 2020
    Publication date: May 21, 2020
    Applicant: ENVIROLOGIX INC.
    Inventor: STEPHEN A. JUDICE
  • Biological sample analytical instrument
    Patent number: 10632444
    Abstract: A method for processing a biological material sample includes dispensing a sample into wells of an array tape from a sample plate, dispensing a reagent into the wells of the array tape from a reagent plate, and sealing the sample and the reagent in the array tape. The method further includes cooling the array tape and detecting biological material in the wells of the array tape.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: April 28, 2020
    Assignee: DOUGLAS SCIENTIFIC, LLC
    Inventors: Mark Whalen, Charles Gervais, Anthony Sanborn, Andrew Haug, Darren Cook, Satish Rai, Hans A. Mische, Stephen A. Judice, Daniel J. Shaffer
  • Compositions and methods for detecting a nucleic acid sequence in a sample comprising a primer oligonucleotide with a 3?-terminal region comprising a 2?-modified nucleotide
    Patent number: 10584376
    Abstract: The present invention features compositions and methods for quantifying detection of a target oligonucleotide in a sample in real time comprising one or more primer oligonucleotides comprising a 5? nicking enzyme recognition site and a 3?-terminal region comprising a 2?-modified nucleotide. These methods are compatible with amplification of target oligonucleotides in a test sample, including biological samples, using a nicking amplification reaction.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: March 10, 2020
    Assignee: ENVIROLOGIX INC.
    Inventors: Daniel Shaffer, Stephen A. Judice
  • Compositions and methods for detecting nicking enzyme and polymerase activity using a substrate molecule
    Patent number: 10570441
    Abstract: The present invention provides compositions and methods for assaying the activity of nicking enzyme and polymerase in a reaction involving the use of a nucleic acid substrate molecule that detects nicking enzyme and polymerase extension activities by the release of a detectable reporter (e.g., a fluorophore).
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: February 25, 2020
    Assignee: ENVIROLOGIX INC.
    Inventor: Stephen A. Judice
  • COMPOSITIONS AND METHODS FOR QUANTIFYING A NUCLEIC ACID SEQUENCE IN A SAMPLE
    Publication number: 20180363046
    Abstract: The present invention features compositions and methods for quantifying detection of a target oligonucleotide in a sample in real time. These methods are compatible with target oligonucleotides amplified using a NEAR reaction.
    Type: Application
    Filed: August 30, 2018
    Publication date: December 20, 2018
    Applicant: ENVIROLOGIX INC.
    Inventors: Daniel Shaffer, Stephen A. Judice
  • Compositions and methods for detecting a nucleic acid sequence in a sample comprising a primer oligonucleotide with a 3?-terminal region comprising a 2?-modified nucleotide
    Patent number: 10077467
    Abstract: The present invention features compositions and methods for quantifying detection of a target oligonucleotide in a sample in real time. These methods are compatible with target oligonucleotides amplified using a NEAR reaction.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: September 18, 2018
    Assignee: ENVIROLOGIX INC.
    Inventors: Daniel Shaffer, Stephen A. Judice
  • COMPOSITIONS AND METHODS FOR AMPLIFYING A NUCLEIC ACID SEQUENCE IN A SAMPLE
    Publication number: 20180094310
    Abstract: The present invention features compositions and methods for quantifying detection of a target oligonucleotide in a sample in real time. These methods are compatible with target oligonucleotides amplified using a NEAR reaction.
    Type: Application
    Filed: November 9, 2017
    Publication date: April 5, 2018
    Applicant: ENVIROLOGIX INC.
    Inventors: DANIEL SHAFFER, STEPHEN A. JUDICE
  • SUBSTRATE MOLECULE
    Publication number: 20180037940
    Abstract: The present invention provides compositions and methods for assaying the activity of nicking enzyme and polymerase in a reaction involving the use of a nucleic acid substrate molecule that detects nicking enzyme and polymerase extension activities by the release of a detectable reporter (e.g., a fluorophore).
    Type: Application
    Filed: January 25, 2016
    Publication date: February 8, 2018
    Applicant: ENVIROLOGIX INC.
    Inventor: STEPHEN A. JUDICE
  • Compositions and methods for rapid detection of
    Patent number: 9845510
    Abstract: The present invention features rapid and accurate methods for detecting Salmonella (e.g., in a food product, environmental sample, biological sample or other material).
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: December 19, 2017
    Assignee: ENVIROLOGIX INC.
    Inventors: Lars E. Peters, Vikrant Dutta, Thomas Guerrette, Stephen A. Judice, Breck O. Parker
  • COMPOSITIONS AND METHODS FOR DETECTING AN RNA VIRUS
    Publication number: 20170327911
    Abstract: The present invention provides methods for rapidly identifying an RNA viral infection using an isothermal nucleic acid amplification reaction that can be carried out extracted RNA in the context of a crude biological sample.
    Type: Application
    Filed: October 20, 2015
    Publication date: November 16, 2017
    Applicant: Envirologix Inc.
    Inventors: Lars PETERS, Stephen A. JUDICE, Daniel SHAFFER, Breck PARKER