Patents by Inventor Stephen A. Munk

Stephen A. Munk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20220204558
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: March 14, 2022
    Publication date: June 30, 2022
    Inventors: Vince Ammoscato, John E. Bishop, Fang-Ting Chiu, Achim Geiser, Jean-Marc Gomez, Robert Hett, Christoph Koellner, Vithalanand R. Kulkami, Young Lo, Stephen Munk, I. Fraser Pickersgill
  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20210395301
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: September 2, 2021
    Publication date: December 23, 2021
    Inventors: Vince Ammoscato, John E. Bishop, Fang-Ting Chiu, Achim Geiser, Jean-Marc Gomez, Robert Hett, Christoph Koellner, Vithalanand R. Kulkarni, Young Lo, Stephen Munk, I. Fraser Pickersgill
  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20210171574
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: February 19, 2021
    Publication date: June 10, 2021
    Inventors: Vince Ammoscato, John E. Bishop, Fang-Ting Chiu, Achim Geiser, Jean-Marc Gomez, Robert Hett, Christoph Koellner, Vithalanand R. Kulkarni, Young Lo, Stephen Munk, I. Fraser Pickersgill
  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20200369722
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: August 13, 2020
    Publication date: November 26, 2020
    Inventors: Vince Ammoscato, John E. Bishop, Fang-Ting Chiu, Achim Geiser, Jean-Marc Gomez, Robert Hett, Christoph Koellner, Vithalanand R. Kulkarni, Young Lo, Stephen Munk, I. Fraser Pickersgill
  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20200157143
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 21, 2020
    Inventors: Vince Ammoscato, John E. Bishop, Fang-Ting Chiu, Achim Geiser, Jean-Marc Gomez, Robert Hett, Christoph Koellner, Vithalanand R. Lulkarni, Young Lo, Stephen Munk, I.Fraser Pickersgill
  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20190330270
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: July 11, 2019
    Publication date: October 31, 2019
    Inventors: Vince Ammoscato, John E. Bishop, Fang-Ting Chiu, Achim Geiser, Jean-Marc Gomez, Robert Hett, Christoph Koellner, Vithalanand R. Kulkarni, Young Lo, Stephen Munk, I. Fraser Pickersgill
  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20190112334
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 18, 2019
  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20180265546
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: May 23, 2018
    Publication date: September 20, 2018
  • Synthesis of boronic ester and acid compounds
    Patent number: 10000529
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: June 19, 2018
  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20180044377
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: September 22, 2017
    Publication date: February 15, 2018
  • Synthesis of boronic ester and acid compounds
    Patent number: 9862745
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: January 9, 2018
  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20160362449
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: January 8, 2016
    Publication date: December 15, 2016
  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20150038706
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: March 6, 2014
    Publication date: February 5, 2015
  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20130005968
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 3, 2013
  • Synthesis of boronic ester and acid compounds
    Patent number: 8283467
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: October 9, 2012
  • SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
    Publication number: 20100174072
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: February 16, 2010
    Publication date: July 8, 2010
  • Synthesis of boronic ester and acid compounds
    Publication number: 20050240047
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: March 24, 2005
    Publication date: October 27, 2005
  • Process for the preparation of 9-?-anomeric nucleoside analogs
    Patent number: 6884880
    Abstract: A process for substantially enhancing the regio and stereoselective synthesis of 9-?-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9-?-D- or L-purine nucleoside analogs were obtained. This regio and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs and in particular 2?-deoxy, 3?-deoxy, 2?-deoxy-2?-?-fluoro and 2?,3?-dideoxy-2?-?-fluoro purine nucleoside analogs in high yield without virtually any formation of the 7-positional isomers. The compounds are drugs or intermediates to drugs.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: April 26, 2005
    Assignee: Ash Stevens, Inc.
    Inventors: Pranab K. Gupta, Stephen A. Munk
  • Imidiazoles having reduced side effects
    Patent number: 6841684
    Abstract: Methods and compounds for the treatment of conditions including pain, particularly chronic pain, glaucoma or elevated intraocular pressure with reduced cardiovascular or sedative side effects. Also included are methods of making and using such compounds.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: January 11, 2005
    Assignee: Allergan, Inc.
    Inventors: Ken Chow, Daniel W. Gil, James A. Burke, Dale A. Harcourt, Michael E. Garst, Larry A. Wheeler, Stephen A. Munk, Dario G. Gomez, Todd M. Heidelbaugh
  • Conformationally rigid bicyclic and adamantane derivatives useful as &agr;2-adrenergic blocking agents
    Patent number: 6706747
    Abstract: A compound of formula I in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; X is nitrogen, oxygen or sulfur; R is hydrogen, lower straight or branched chain alkyl of 1 to 6 carbon atoms, or lower straight or branched chain alkenyl of 2 to 6 carbon atoms, a cycloaliphatic ring of 3 to 6 carbon atoms, phenyl optionally mono- or di-substituted with hydroxy, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 2 carbon atoms, or methylenedioxyphenyl; or a stereoisomer, or a pharmaceutically acceptable salt thereof. These compounds have &agr;2 receptor blocking activity and hence find use in the treatment or palliation of elevated intraocular pressure, non insulin-dependent diabetes, male impotence and obesity.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: March 16, 2004
    Assignee: Allergan, Inc.
    Inventors: Stephen A. Munk, James A. Burke, Michael E. Garst