Abstract: Novel nickel and/or cobalt plated sponge based catalysts are disclosed. The catalyst have an activity and/or selectivity comparable to conventional nickel and/or cobalt sponge catalysts, e.g., Raney® nickel or Raney® cobalt catalysts, but require a reduced content of nickel and/or cobalt. Catalysts in accordance with the invention comprise nickel and/or cobalt coated on at least a portion of the surface of a sponge support. Preferably, the sponge support comprises at least one metal other than or different from the metal(s) contained in the coating. The method of preparing the plated catalysts, and the method of using the catalysts in the preparation of organic compounds are also disclosed.

Abstract: A process for the manufacture of a powder coating comprising the steps of: Preparing a powder coating premix comprising a resin and optionally a crosslinker therefor; Feeding the premix through a melt extruder; Cooling the extruded material; and Comminuting it to fine particles, wherein said process is characterized in that between 1 and 25 wt. % (based on the weight of said premix) of a process liquid is added to the melt extruder, wherein said process liquid is immiscible with at least said resin of the powder coating premix and wherein said process liquid evaporates when the premix leaves the extruder.

Abstract: The present invention provides methods for inhibiting the anticoagulation effect of a thrombin inhibitor in a patient in need thereof comprising administration of a therapeutically effective amount of a variant prothrombin or thrombin that is capable of binding the thrombin inhibitor and that has reduced procoagulant activity. Variant prothrombins or thrombins of use in the methods of the present invention include thrombin mutants W215A, W215A/E217A, or variants thereof in which the amino acids at positions 215 and/or 217 are alanine. Methods are also provided in which the thrombin mutants are administered with an additional active agent, particularly hemostatic agents such as activated factor VII or activated prothrombin complex concentrate. In one embodiment of the invention, the methods are useful in the treatment of patients in which a direct thrombin inhibitor has been administered, particularly argatroban.

Abstract: A health monitoring device that includes a data logger module that collects health information from a subject or clinician during specific time ranges that are part of a health monitoring schedule. The collected health information and/or the time ranges are determined in part by the content of the collected health information. The device records the collected health information along with a time stamp. The device also includes a clock and a time travel mode that allows a user to adjust the clock to a specified point in the health monitoring schedule so that the device operates at the specified point in the same manner as if the device had reached the specified point without intervention by the user to adjust the clock.

Abstract: The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention is relied on color change to indicate the readiness of disinfection and cleaning of contact lenses.

Abstract: The present invention provides a method for producing a medical device, preferably an ophthalmic device, more preferably a contact lens, made of a stabilized poly(oxyalkylene)-containing polymeric material. The method of the invention comprises the steps of: curing, in a mold, a composition comprising (a) a prepolymer having at least one poly(oxyalkylene) unit, (b) a biocompatible organic multi-acid or biocompatible salt thereof in an amount sufficient to improve the stability of the poly(oxyalkylene)-containing polymer made from the composition, (c) optionally a photoinitiator or a thermal initiator, and (d) optionally one or more vinylic monomers, to form the medical device being less susceptible to oxidative degradation; and removing the medical device from the mold.

Abstract: Novel nickel and/or cobalt plated sponge based catalysts are disclosed. The catalyst have an activity and/or selectivity comparable to conventional nickel and/or cobalt sponge catalysts, e.g., Raney® nickel or Raney® cobalt catalysts, but require a reduced content of nickel and/or cobalt. Catalysts in accordance with the invention comprise nickel and/or cobalt coated on at least a portion of the surface of a sponge support. Preferably, the sponge support comprises at least one metal other than or different from the metal(s) contained in the coating. The method of preparing the plated catalysts, and the method of using the catalysts in the preparation of organic compounds are also disclosed.

Abstract: An insertion device for inserting an infusion device at least partially into skin for subcutaneous infusion can comprise a sleeve having a lower surface that is configured to engage the skin, a shuttle or carriage to carry the infusion device between a retracted position and an advanced position; at least a first biasing member to urge the shuttle or carriage toward the advanced position, and an actuator to cause the first biasing member to urge the carriage from the retracted position to the advanced position. In some embodiments, the insertion device can further comprise a hub and at least a second biasing member to urge the hub away from the shuttle or carriage. In some embodiments, the insertion device can further comprise a needle attached to the hub. Methods for inserting an infusion device and various other features that can be comprised by an insertion device are also disclosed.

Abstract: Novel nickel and/or cobalt plated sponge based catalysts are disclosed. The catalyst have an activity and/or selectivity comparable to conventional nickel and/or cobalt sponge catalysts, e.g., Raney® nickel or Raney® cobalt catalysts, but require a reduced content of nickel and/or cobalt. Catalysts in accordance with the invention comprise nickel and/or cobalt coated on at least a portion of the surface of a sponge support. Preferably, the sponge support comprises at least one metal other than or different from the metal(s) contained in the coating. The method of preparing the plated catalysts, and the method of using the catalysts in the preparation of organic compounds are also disclosed.

Abstract: Novel nickel and/or cobalt plated sponge based catalysts are disclosed. The catalyst have an activity and/or selectivity comparable to conventional nickel and/or cobalt sponge catalysts, e.g., Raney® nickel or Raney® cobalt catalysts, but require a reduced content of nickel and/or cobalt. Catalysts in accordance with the invention comprise nickel and/or cobalt coated on at least a portion of the surface of a sponge support. Preferably, the sponge support comprises at least one metal other than or different from the metal(s) contained in the coating. The method of preparing the plated catalysts, and the method of using the catalysts in the preparation of organic compounds are also disclosed.

Abstract: A health monitoring system which tracks the state of health of a patient and compiles a chronological health history of the patient uses a multiparametric monitor which periodically and automatically measures and records a plurality of physiological data from sensors in contact with the patient's body. The data collected is periodically uploaded to a database in which it is stored along with similar health histories for other patients. The monitor is preferably self-contained in a chest strap which is located on the patient's torso, and makes use of a controller which controls sampling of the desired data and storage of the data to a local memory device pending uploading to the database. The data includes voice sound data indicative of voice sounds made by the subject over a predetermined period of time.

Abstract: A device for rotating with a rotatable first member includes a second member having a portion engageable with the first member. The portion has a first part and a second part which is resiliently biased away from the first part. The second member tightly engages the first member. There may be a device for measuring rotation of the shaft such as a potentiometer. The rotation measuring device may include an electrical connector for the potentiometer including a socket and a post which is pressable into the socket. The device may also include a rotationally adjustable connector. There may be a coupling connected to the second member which includes a third member with a portion having n sides and a fourth member with a portion having n sides which receives the portion of the third member in a mating relationship, thereby allowing the device to be adjusted to a total of at least m.n rotational positions.

Abstract: A method, system and computer program product for displaying resource utilization information for a plurality of resources is provided. A time period is determined in which to measure the resource utilization information. The resource utilization information is monitored based on the time period. A result of the monitoring of the resource utilization information is displayed, wherein the result of the monitoring of the resource utilization information is dynamically displayed so as to provide an indication of utilization of a resource within the plurality of resources relative to a resource reference level.

Abstract: A device for rotating with a rotatable first member includes a second member having a portion engageable with the first member. The portion has a first part and a second part which is resiliently biased away from the first part. The second member tightly engages the first member. There may be a device for measuring rotation of the shaft such as a potentiometer. The rotation measuring device may include an electrical connector for the potentiometer including a socket and a post which is pressable into the socket. The device may also include a rotationally adjustable connector. There may be a coupling connected to the second member which includes a third member with a portion having n sides and a fourth member with a portion having n sides which receives the portion of the third member in a mating relationship, thereby allowing the device to be adjusted to a total of at least m.n rotational positions.

Abstract: Novel nickel and/or cobalt plated sponge based catalysts are disclosed. The catalyst have an activity and/or selectivity comparable to conventional nickel and/or cobalt sponge catalysts, e.g., Raney® nickel or Raney® cobalt catalysts, but require a reduced content of nickel and/or cobalt. Catalysts in accordance with the invention comprise nickel and/or cobalt coated on at least a portion of the surface of a sponge support. Preferably, the sponge support comprises at least one metal other than or different from the metal(s) contained in the coating. The method of preparing the plated catalysts, and the method of using the catalysts in the preparation of organic compounds are also disclosed.

Abstract: The present invention provides a method for producing a medical device, preferably an ophthalmic device, more preferably a contact lens, made of a stabilized poly(oxyalkylene)-containing polymeric material. The method of the invention comprises the steps of: curing, in a mold, a composition comprising (a) a prepolymer having at least one poly(oxyalkylene) unit, (b) a biocompatible organic multi-acid or biocompatible salt thereof in an amount sufficient to improve the stability of the poly(oxyalkylene)-containing polymer made from the composition, (c) optionally a photoinitiator or a thermal initiator, and (d) optionally one or more vinylic monomers, to form the medical device being less susceptible to oxidative degradation; and removing the medical device from the mold.

Abstract: A health monitoring system which tracks the state of health of a patient and compiles a chronological health history of the patient uses a multiparametric monitor which periodically and automatically measures and records a plurality of physiological data from sensors in contact with the patient's body. The data collected is periodically uploaded to a database in which it is stored along with similar health histories for other patients. The monitor is preferably self-contained in a chest strap which is located on the patient's torso, and makes use of a controller which controls sampling of the desired data and storage of the data to a local memory device pending uploading to the database. The data includes voice sound data indicative of voice sounds made by the subject over a predetermined period of time.

Abstract: An improved flatting agent comprising an inorganic hydrogel having a pore volume of at least 1.0 ml/g, an average particle size in the range 1 to 10 microns, and a particle size distribution such that when the flatting agent is dispersed in a coating, the fineness of grind is at least 4.75 on the Hegman scale. The inorganic hydrogel flatting agents of this invention are prepared by milling an inorganic hydrogel under controlled temperature conditions wherein a volatiles content of at least 40 weight percent is maintained, to produce inorganic hydrogel particles characterized by a pore volume of at least 1.0 ml/g, an average particle size in the range of 1 to 10 microns, and a particle size distribution such that when the flatting agent is dispersed in a coating, the fineness of grind is at least 4.75 on the Hegman scale.

Abstract: Compositions comprising glycerides containing conjugated linoleic acid moieties. These glycerides are prepared by an enzymatic conversion process which is selective to provide specific isomers, advantageously the cis9, trans11 and trans10, cis12 linoleic acid isomers or vice versa. The compositions may be blended with complementary fats and may be used in foods, food supplements and pharmaceutical compositions.

Abstract: A device for rotating with a rotatable first member includes a second member having a portion engageable with the first member. The portion has a first part and a second part which is resiliently biased away from the first part. The second member tightly engages the first member. There may be a device for measuring rotation of the shaft such as a potentiometer. The rotation measuring device may include an electrical connector for the potentiometer including a socket and a post which is pressable into the socket. The device may also include a rotationally adjustable connector. There may be a coupling connected to the second member which includes a third member with a portion having n sides and a fourth member with a portion having n sides which receives the portion of the third member in a mating relationship, thereby allowing the device to be adjusted to a total of at least m.n rotational positions.