Abstract: In a method for placing a telephone call, a first telephone receives a request to call a second telephone. The first telephone retrieves a user preference for obtaining location information of the second telephone or of a user of the second telephone. The first telephone obtains the location information from one of a plurality of sources based at least in part on an order of priority of the sources defined by the user preference. The plurality of sources include a social network program. The first telephone determines a local time in a geographical location identified from the location information. The first telephone displays the local time. The first telephone prompts for a decision whether to place the call to the second telephone.

Abstract: Personal digital assistant devices are provided that query power subsystems to determine a level of battery power currently available for operating processes, and further determine a number of screen display changes that may be effected on a persistent display device at that determined level. If the determined number of screen display changes that may be effected at the determined level of available battery power fails to meet a specified minimum threshold number of images, the processing unit powers down subsystems of the personal digital assistant device and causes a highest listed image of a prioritized list of screen image instances to be displayed on the persistent display device, which persistently displays the image after a loss of power.

Abstract: In a method for placing a telephone call, a first telephone receives a request to call a second telephone. The first telephone retrieves a user preference for obtaining location information of the second telephone or of a user of the second telephone. The first telephone obtains the location information from one of a plurality of sources based at least in part on an order of priority of the sources defined by the user preference. The plurality of sources include a social network program. The first telephone determines a local time in a geographical location identified from the location information. The first telephone displays the local time. The first telephone prompts for a decision whether to place the call to the second telephone.

Abstract: In a method for placing a telephone call, a telephone receives a request to call a contact. The telephone retrieves a user preference for obtaining an availability status of the contact. The telephone obtains the availability status of the contact from one of a plurality of sources based at least in part on an order of priority of the sources defined by the user preference. The sources include a social network program. The telephone displays the status of the contact. The telephone prompts for a decision whether to place the call to the contact.

Abstract: Embodiments comprise a plurality of computing devices that dynamically intercept process application I/O errors. Various embodiments comprise two or more computing devices, such as two or more servers, each having access to a shared data storage system. An application may be executing on the first computing device and performing an I/O operation when an I/O error occurs. The first computing device may intercept the I/O error, rather than passing it back to the application, and prevent the error from affecting the application. The first computing device may complete the I/O operation, and any other pending I/O operations not written to disk, via an alternate path, perform a checkpoint operation to capture the state of the set of processes associated with the application, and transfer the checkpoint image to the second computing device. The second computing device may resume operation of the application from the checkpoint image.

Abstract: Compounds that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA lesions, and methods to potentiate cancer treatment are disclosed.

Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract: Compound that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods of inhibiting the DNA-PK biological activity, methods of sensitizing cells the agents that cause DNA lesions, and methods of potentiating cancer treatment are disclosed.

Abstract: Disclosed are compounds of the Formula I and diastereomers, tautomers, solvates, metabolites, and pharmaceutically acceptable salts thereof, wherein X, A, L and Y are as defined herein. Such compounds are useful in the treatment of immunoregulatory and respiratory diseases in mammals. Also disclosed are methods of using such compounds in the treatment of immunoregulatory and respiratory diseases in mammals and pharmaceutical compositions containing such compounds.

Abstract: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.