Abstract: Characterization of proteins and/or protein complexes using covalent labeling denaturation methodology are described.

Abstract: The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R1-H which comprises a first functional moiety of formula F1 to a second functional moiety of formula F2 wherein X, X?, Y, R1, F1 and F2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.

Abstract: A solid-production system for producing a solid on demand is provided herein. In some aspects, the solid-production system includes a conveying mechanism; a fluid-dispensing mechanism; a pressure plate arranged to urge the fluid mold into interaction with a cooling block to form a solid; a solid-dispensing mechanism arranged to dispense the solid loosened by a solid ejector to a user; and processing circuitry configured to implement a master state machine, and slave state machines for respective ones of the fluid-dispensing mechanism, conveying mechanism, pressure plate and solid-dispensing mechanism, wherein the master state machine is configured to send commands to the slave state machines based on states of the slave state machines, and the slave state machines are configured to execute the commands to control the respective ones of the conveying mechanism, fluid-dispensing mechanism, pressure plate, and solid-dispensing mechanism.

Abstract: A solid-production system for producing a solid on demand is disclosed herein. In some aspects, the solid-production system includes a cooling block arranged to interact with one or more fluid molds to reduce a first temperature of a fluid dispensed in each of the one or more fluid molds to a second temperature, the second temperature being lower than the first temperature, to solidify the fluid in each of the one or more fluid molds; wherein the cooling block has a thermal mass operable to absorb and store thermal energy transferred by the fluid in each of the one or more fluid molds so as to reduce the first temperature of the fluid to the second temperature.

Abstract: A solid production system for producing a solid on demand is provided herein. In some aspects, the solid-production system includes a solid ejector arranged to loosen a solid in each of one or more fluid molds indexed into an ejection position relative to the solid ejector, the one or more fluid molds including a bottom surface and side surfaces extending therefrom, wherein the solid ejector is actuatable so as to be urged into contact with and to apply pressure to at least one of the side surfaces of the fluid mold indexed into the ejection position so as to loosen the solid within the fluid mold in preparation for dispensing the solid from the fluid mold.

Abstract: A hardware acceleration component is provided that includes a plurality of hardware clusters, each hardware cluster comprising a plurality of soft processor cores and a functional circuit. The plurality of soft processor cores share the functional circuit.

Abstract: An integrated process is useful for producing 2,5-furandicarboxylic acid (FDCA) and/or a derivative thereof from a six-carbon sugar-containing feed. The process includes a) dehydrating a feed containing a six-carbon sugar unit, in the presence of a bromine source and of a solvent, to generate an oxidation feed that contains at least one of 5-hydroxymethylfurfural (HMF) and/or a derivative or derivatives of HMF in the solvent, together with at least one bromine containing species; b) contacting the oxidation feed from step (a) with a metal catalyst and with an oxygen source under oxidation conditions to produce an oxidation product mixture of at least FDCA and/or a derivative thereof, the solvent, and a residual catalyst: c) purifying and separating the mixture obtained in step (b) to obtain FDCA and/or a derivative thereof and the solvent; and d) recycling at least a portion of the solvent obtained in step (c) to step (a).

Abstract: A system includes at least a computing apparatus including a communication interface coupled or coupleable to a sensor in contact with a heatable liquid contained in a vessel, the sensor being configured to obtain measurements of a property of the liquid or the sensor; and a processor coupled to the communication interface and configured to receive the measurements of the property of the liquid or the sensor. The processor is programmed to at least determine a height of the liquid in the vessel, and in at least one instance oscillation of the height of the liquid in the vessel, from the measurements, determine an amplitude of the oscillation, determine a level of boil of the liquid from the amplitude of the oscillation and a viscosity of the liquid, and output an indication of the level of boil for display or control of the heat to which the liquid is subjected.

Abstract: Disclosed herein are electronic devices having a deformable surfaces through which a user can provide inputs to the device by applying a force such as a pinch or a squeeze. A particular embodiment is an earpiece with the deformable surface part of an elongate section extending from an earbud. The deformable surface includes an incompressible hyperelastic material and a pressure sensor. The pressure sensor includes a pressure sensing element and a void defined between the pressure sensing element and the incompressible hyperelastic material. An applied force is transferred by the incompressible hyperelastic material to compress the void and change an internal pressure thereof. The changed pressure is detected by the pressure sensor, and can result in changed operation of the electronic device.

Abstract: A transparent force sensor for detecting an applied force on a surface of a device. The transparent force sensor includes a transparent force-sensitive film having an array of strain-relief features oriented along a first direction. The transparent force-sensitive film is formed from a transparent piezoelectric material that exhibits a substantially reduced net charge when strained along a primary direction. The force sensor also includes a display element disposed on one side of the transparent force-sensitive film.

Abstract: Implementations described herein provide a cooling base and a substrate support assembly having the same. In one example, a cooling base is provided that includes a body coupled to a cap. A plurality cooling channels are disposed in the body and bounded on at least one side by the cap. The plurality cooling channels have a polar array of spirals.

Abstract: A wireless power transmitting device transmits wireless power signals to a wireless power receiving device. The wireless power receiving device has a rectifier and a wireless power receiving coil that receives wireless power signals. The wireless power transmitting device uses a layer of coils to transmit the wireless power signals. A dielectric layer in the wireless power transmitting device defines a charging surface that receives the wireless power receiving device. A layer of temperature sensors is interposed between the layer of coils and the dielectric layer. Control circuitry in the wireless power transmitting device uses temperature information from the temperature sensors to determine whether a foreign object such as a coin is present on the charging surface.

Abstract: Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralise eotaxin-1 activity. The antibodies VH and/or VL domain of the scFv fragment herein termed CAT-212 and of the IgG4 antibody herein termed CAT 213. One or more complementary determining regions (CDRs) of the CAT-213/-213 VH and/or VL domains especially VH CRD3 in other antibody framework regions. Compositions containing specific binding members and their use in methods of inhibiting or neutralising eotaxin, including methods of treatment or the human or animal body by therapy.

Abstract: Technologies are described for enabling co-streaming of live video game streams by multiple broadcasters. For example, broadcasters that are eligible to co-stream can be determined. Invitations can be sent to the broadcasters to join a co-stream. After acceptance, a co-stream can be created. The co-stream can be streamed to viewer devices.

Abstract: A method of determining an absorption or turbidity coefficient of a liquid involves storing a set of data describing a plurality of droplets or other discrete bodies of liquid of different shapes, sizes and absorption or turbidity coefficients. Each body is captured as a combination of a measurable transmission parameter obtained by modelling the interaction of light with a drop, and of one or more dimensional measurements selected from lengths, areas and volumes. The absorption or turbidity coefficient is indicated also. By measuring the transmission of light through a real body of liquid, and making measurements allowing the droplet to be specified, the absorption or turbidity coefficient associated with a droplet giving rise to the same behaviour in transmitting light can be identified from the data set.

Abstract: The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R1—H which comprises a first functional moiety of formula F1 to a second functional moiety of formula F2 wherein X, X?, Y, R1, F1 and F2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.

Abstract: Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.

Abstract: An integrated process is described for producing 2,5-furandicarboxylic acid and/or a derivative thereof from a six carbon sugar-containing feed, comprising: a) dehydrating a feed comprising a six-carbon sugar unit, in the presence of a bromine source and of a solvent, to generate an oxidation feed comprised of at least one of 5-hydroxymethylfurfural and/or a derivative or derivatives of 5-hydroxymethylfurfural in the solvent, together with at least one bromine containing species; b) contacting the oxidation feed from step (a) with a metal catalyst and with an oxygen source under oxidation conditions to produce an oxidation product mixture comprising 2,5-furandicarboxylic acid (FDCA) and/or a derivative thereof, the solvent, and a residual catalyst; c) purifying and separating the mixture obtained in step (b) to obtain FDCA and/or a derivative thereof and the solvent; and d) recycling at least a portion of the solvent obtained in step (c) to step (a).

Abstract: A method (100) is disclosed, the method being performed in a network controller of a Mobile Transport Network. The Mobile Transport Network comprises communication links interconnecting network entities of a cellular Radio Access Network (RAN) and a core network. The method comprises receiving, from a network entity in the core network, an indication of traffic load within the RAN or between the RAN and the core network (102). Also disclosed is a method (200), performed in a network entity of a core network, the core network being connected to a cellular RAN by a Mobile Transport Network. The Mobile Transport Network comprises communication links interconnecting network entities of the core network and the RAN. The method (200) comprises sending to a network controller of the Mobile Transport Network an indication of traffic load within the RAN or between the RAN and the core network (202).