Patents by Inventor Stephen Alan Fakhoury

Stephen Alan Fakhoury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-phenylamino-quinazolin-6-yl-amides
    Patent number: 8623883
    Abstract: This invention provides quinazoline compounds of the formula: wherein: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted by halo; or b) —(CH2)n-morpholino, —(CH2)n-piperidine, —(CH2)n-piperazine, —(CH2)n-piperazine-N(C1-C3 alkyl), —(CH2)n-pyrrolidine, or —(CH2)n-imidazole; n is 1 to 4; R4 is —(CH2)m-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N(C1-C3 alkyl)2; m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: January 7, 2014
    Assignee: Warner-Lambert Company LLC
    Inventors: Stephen Alan Fakhoury, Helen Tsenwhei Lee, Jessica Elizabeth Reed, Kevin Matthew Schlosser, Karen Elaine Sexton, Haile Tecle, Roy Thomas Winters
  • 4-phenylamino-quinazolin-6-yl-amides
    Patent number: 8466165
    Abstract: This invention provides quinazoline compounds of the formula: wherein: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted by halo; or b) —(CH2)n-morpholino, —(CH2)n-piperidine, —(CH2)n-piperazine, —(CH2)n-piperazine-N(C1-C3 alkyl), —(CH2)n-pyrrolidine, or —(CH2)n-imidazole; n is 1 to 4; R4 is —(CH2)m-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N(C1-C3 alkyl)2; m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: June 18, 2013
    Assignee: Warner-Lambert Company LLC
    Inventors: Stephen Alan Fakhoury, Helen Tsenwhei Lee, Jessica Elizabeth Reed, Kevin Matthew Schlosser, Karen Elaine Sexton, Haile Tecle, Roy Thomas Winters
  • 4-phenylamino-quinazolin-6-yl-amides
    Patent number: 7772243
    Abstract: This invention provides quinazoline compounds of the formula: wherein: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted by halo; or b) —(CH2)n-morpholino, —(CH2)n-piperidine, —(CH2)n-piperazine, —(CH2)n—-piperazine-N(C1-C3 alkyl), —(CH2)n-pyrrolidine, or —(CH2)n-imidazole; n is 1 to 4; R4 is —(CH2)m-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N (C1-C3 alkyl)2; m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: August 10, 2010
    Assignee: Warner-Lambert Company LLC
    Inventors: Stephen Alan Fakhoury, Helen Tsenwhei Lee, Jessica Elizabeth Reed, Kevin Matthew Schlosser, Karen Elaine Sexton, Haile Tecle, Roy Thomas Winters
  • 4-PHENYLAMINO-QUINAZOLIN-6-YL-AMIDES
    Publication number: 20100190977
    Abstract: This invention provides quinazoline compounds of the formula: wherein: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted by halo; or b) —(CH2)n-morpholino, —(CH2)n-piperidine, —(CH2)n-piperazine, —(CH2)n-piperazine-N(C1-C3 alkyl), —(CH2)n-pyrrolidine, or —(CH2)n-imidazole; n is 1 to 4; R4 is —(CH2)m-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N(C1-C3 alkyl)2; m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.
    Type: Application
    Filed: April 5, 2010
    Publication date: July 29, 2010
    Inventors: Stephen Alan Fakhoury, Helen Tsenwhei Lee, Jessica Elizabeth Reed, Kevin Matthew Schlosser, Karen Elaine Sexton, Haile Tecle, Roy Thomas Winters
  • ANDROGEN MODULATORS
    Publication number: 20090170886
    Abstract: The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Application
    Filed: July 7, 2006
    Publication date: July 2, 2009
    Inventors: Mark Laurence Boys, Michelle Marie Bruendl, Victoria Leigh Downs, Stephen Alan Fakhoury, William Glen Harter, Lain-Yen Hu, Sandra Marie Jennings, Bruce Allen Lefker, Lorna Helen Mitchell, Raj Kumar Raheja, Yvonne Dorothy Smith
  • ESTROGEN MODULATORS
    Publication number: 20090131397
    Abstract: The present application is directed to a new class of isoxazoles and their use as estrogen modulators.
    Type: Application
    Filed: October 31, 2008
    Publication date: May 21, 2009
    Inventors: Simon Bailey, Stephen Douglas Barrett, Larry Don Bratton, Stephen Alan Fakhoury, Sandra Marie Jennings, Lorna Helen Mitchell, Raj Kumar Raheja, Veerabahu Shanmugasundaram
  • Antidiabetic agents
    Publication number: 20030171377
    Abstract: The present invention provides compounds of Formula (I): 1
    Type: Application
    Filed: August 22, 2002
    Publication date: September 11, 2003
    Inventors: Christopher Franklin Bigge, Alexander James Bridges, Agustin Casimiro-Garcia, Stephen Alan Fakhoury, Helen Tsenwhei Lee, Jessica Reed, Robert Schaum, Kevin Matthew Schlosser, Karen Sexton, Hairong Zhou