Abstract: Provided herein are methods of identifying neoantigens for diagnosing, treating, and preventing cancer. Also provided herein are methods of measuring antibody response to one or more frameshift peptides caused by exon 1 mis-initiation. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.

Abstract: The present invention relates to methods of inhibiting the expression of an AGT gene in a subject, as well as methods for treating subjects having an AGT-associated disorder, e.g., hypertension, using RNAi agents, e.g., double stranded RNAi agents, targeting the AGT gene. The invention also relates to methods of decreasing blood pressure levels in a subject using such RNAi agents to inhibit expression of an AGT gene.

Abstract: Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.

Abstract: Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.

Abstract: Provided herein, are methods of treating cancer in dogs using personalized cancer vaccines comprising peptides having frameshift mutations caused by errors in transcription and splicing of an mRNA.

Abstract: Provided herein are vaccine compositions for use in immunotherapy for canine cancers, and methods of canine cancer immunotherapy using said compositions. The compositions and methods provided herein include DNA vaccines having two plasmids that encode thirty-one peptide antigens, plus a plasmid that encodes canine GMCSF.

Abstract: A Bag Holder Card for organizing and keeping clean transportation vehicles by inserting a card in between the seat and the center console that has a device that will hold trash receptacles, or other objects, also to contain items in a pouch such as writing tools. The Bag Holder Card generally includes A stable unsecured trash bag support comprising: a support member sufficiently slender so as to fit between a motor vehicle seat and the center console of said vehicle; a stabilizer piece attached to the top portion of said support member sufficient to prevent movement of the support member during traffic; a bag attachment member connected to the forward portion of the support member for the attachment of a trash bag or other item.

Abstract: Disclosed herein are methods to improve effectiveness of cancer vaccines by increasing high affinity T cells number. Methods of eliciting an immune response in a treatment subject in need thereof and methods of treating cancer and/or a tumor in a subject are also disclosed.

Abstract: A mobile cleaning robot includes a removable filter unit configured to receive a supply airflow generated by a blower and to filter debris from the supply airflow, a filter seat, a filter access opening, a filter access door, and a filter presence system. The filter access door is pivotable between a closed position, wherein the filter access door covers the filter access opening, and an open position, wherein the filter access door is displaced from the filter access opening to permit access to the filter seat. The filter presence system is configured to: permit the filter access door to move from the open position into the closed position when the filter unit is disposed in the filter seat; and prevent the filter access door from being moved into the closed position when the filter unit is not disposed in the filter seat. The filter presence system includes a lift arm movable between an extended position and a retracted position.

Abstract: The present invention relates to methods of inhibiting the expression of an AGT gene in a subject, as well as methods for treating subjects having an AGT-associated disorder, e.g., hypertension, using RNAi agents, e.g., double stranded RNAi agents, targeting the AGT gene. The invention also relates to methods of decreasing blood pressure levels in a subject using such RNAi agents to inhibit expression of an AGT gene.

Abstract: A method of producing a set of high affinity peptides for detecting one or more antibodies associated with a disease or condition of interest. The method including identifying a set of informative peptides correlated to the disease or condition of interest and translating the set of informative peptides to one or more high affinity peptides for an antibody of interest, wherein the presence of the antibody of interest identifies a subject as having the disease or condition of interest. A diagnostic peptide array produced from the one or more high affinity. A method of detecting an antibody associated with a disease of condition, including: contacting a biological sample with a diagnostic peptide array; and detecting the binding of one or more antibodies to a peptide that is associated with a disease or condition of interest, thereby detecting the antibody associated with a disease of condition.

Abstract: Provided herein, are methods of treating cancer in dogs using personalized cancer vaccines comprising peptides having frameshift mutations caused by errors in transcription and splicing of an mRNA.

Abstract: A method of producing a therapeutic or preventive antibody for a cancer and/or tumor of interest is disclosed. The methods include binding antibodies of interest to frameshift peptide arrays, selecting frameshift peptides that are immunoreactive to the antibodies, and preparing an antibody composition against the selected frameshift peptides. Also disclosed are antibody compositions, methods of eliciting an immune response and methods of treatment using the methods of producing the antibodies as described herein.

Abstract: Penile straightening devices are disclosed. The proposed invention is used to passively or actively straighten or counter the curvature of an erect penis to reduce or completely eliminate the curvature in a painless, inexpensive, and safe manner.

Abstract: Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.

Abstract: Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.

Abstract: Compositions, methods, systems, apparatus and/or articles of manufacture are disclosed for reducing the susceptibility of a population and/or members thereof to cancer, which may include anti-cancer vaccines, components thereof which may include novopeptides, and methods relating thereto.

Abstract: A method of producing a vaccine for a cancer and/or tumor and stage of interest is disclosed. The method includes identifying a first population of peptides that are immunoreactive with a set of biological samples obtained from a set of test subjects that have been identified as having the cancer and/or tumor of interest, and preparing a cancer vaccine composition for the cancer of interest, wherein the cancer vaccine composition comprises a second population of peptides comprising one or more peptides in the first population or a nucleic acid sequence encoding the one or more peptides, thereby producing the vaccine for the cancer and/or tumor of interest. Also disclosed are vaccine compositions and methods of use thereof.

Abstract: Compositions, methods, systems, apparatus and/or articles of manufacture are disclosed for reducing the susceptibility of a population and/or members thereof to cancer, which may include anti-cancer vaccines, components thereof which may include novopeptides, and methods relating thereto.

Abstract: Disclosed herein are methods and systems for determining microsatellite instability. In some embodiments, the disclosed methods and systems are used for determining whether a cancer patient has high microsatellite instability (MSI-H). MSI-H patients have remarkably good responses to immunotherapy, such as checkpoint inhibitors immunotherapy. Therefore, the disclosed methods and systems can be used for identifying MSI-H and thus, patients as candidates for immunotherapy. In turn, the disclosed methods and systems can be used to predict responsiveness to immunotherapy. In some embodiments, the methods further include providing an immunotherapy to the MSI-H patient. Also disclosed are vaccines and compositions.