Patents by Inventor Stephen Allan Smith

Stephen Allan Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidinone derivatives for the treatment of atherosclerosis
    Patent number: 6559155
    Abstract: Pyrimidones of formula (I) are inhibitors of the enzyme LpPLA2 and thereof use in treating inter alia atherosclerosis, in which: R1 is COOH or a salt thereof, COOR10, CONR11R12, CN or CH2OH; R2 is a mono- or bicyclic aromatic ring system or a mono- or bicyclic heteroaromatic ring system; R3 is C1-20alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-5alkyl, C1-10alkoxyC1-10alkyl, or an aromatic or heteroaromatic ring system; W is SO2 or a bond; X is O or S; and Y is a group of the formula A1—A2—A3 in which A1 and A3 each represent a bond or a straight chain or branched alkylene group, said alkylene group(s) containing a total of 1 to 10 carbon atoms and A2 represents a bond or O, S, SO, SO2, CO, C═CH2, CONH, NHCO, CR15R16, CH═CH or C═C, providing that when A2 is O, S, SO, SO2 or CONH, A3 contains at least two carbon atoms linking the A2 group and the CH2 group in formula (I).
    Type: Grant
    Filed: February 21, 2001
    Date of Patent: May 6, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Colin Andrew Leach, Stephen Allan Smith
  • Pyrimidinone compounds and pharmaceutical compositions containing them
    Publication number: 20020120139
    Abstract: A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2 and therefore of use in treating atherosclerosis.
    Type: Application
    Filed: April 2, 2002
    Publication date: August 29, 2002
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Roderick Alan Porter, Stephen Allan Smith
  • Novel compounds
    Publication number: 20020103213
    Abstract: Pyrimidone compounds of formula (I): 1
    Type: Application
    Filed: February 14, 2001
    Publication date: August 1, 2002
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyrimidinone compounds and pharmaceutical compositions containing them
    Patent number: 6417192
    Abstract: A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2 and therefore of use in treating atherosclerosis.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: July 9, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Roderick Alan Porter, Stephen Allan Smith
  • Tricyclic amine derivatives
    Patent number: 6080752
    Abstract: A compound of formula (I): ##STR1## wherein R.sup.1 represents a group of formula (A) or (B): ##STR2## R.sup.2, R.sup.3, Ar, Y Ar.sup.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: June 27, 2000
    Assignee: SmithKline Beecham PLC
    Inventors: Geoffrey Stemp, Stephen Allan Smith, Christopher Norbert Johnson, Phillip Jeffrey