Patents by Inventor Stephen Arkinstall

Stephen Arkinstall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-TCR ANTIBODY MOLECULES AND USES THEREOF
    Publication number: 20220064255
    Abstract: The disclosure provides methods of expanding T cells ex vivo comprising contacting the T cells with antibody molecules that bind to TCR V? regions. In some embodiments, the T cells comprise one or more nucleic acid molecule encoding an exogenous cellular receptor, for example, a chimeric antigen receptor (CAR) or an exogenous T cell receptor (TCR).
    Type: Application
    Filed: July 2, 2021
    Publication date: March 3, 2022
    Inventors: Andreas Loew, Stephen Arkinstall
  • Pharmaceutically active sulfonyl hydrazide derivatives
    Patent number: 8017628
    Abstract: Sulfonyl hydrazide compounds according to formula I geometrical isomers thereof, optically active enantiomers thereof, diastereomers thereof, racemates thereof, and/or pharmaceutically acceptable salts thereof are useful in method for treating a neuronal disorder, an autoimmune disease, a cardiovascular disease, or cancer in a patient in need of such treatment.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: September 13, 2011
    Assignee: Merck Serono S.A.
    Inventors: Stephen Arkinstall, Serge Halazy, Dennis Church, Montserrat Camps, Thomas Rueckle, Jean-Pierre Gotteland, Marco Biamonte
  • Pharmaceutically active sulfonamide derivatives
    Patent number: 8012995
    Abstract: The present invention is related to sulfonamide derivatives of formula (I0 notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonamide derivatives. Said sulfonamide derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK 2 and 3. The present invention is furthermore related to novel sulfonamide derivatives as well as to methods of their preparation.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: September 6, 2011
    Assignee: Merck Serono SA
    Inventors: Stephen Arkinstall, Serge Halazy, Dennis Church, Montserrat Camps, Thomas Rueckle, Jean Pierre Gotteland, Marco Biamonte
  • Pharmaceutically active sulfonyl amino acid derivatives
    Patent number: 7638538
    Abstract: The present invention is related to sulfonyl amino acid derivatives of formula (I), notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonyl amino acid derivatives. Said sulfonyl amino acid are efficient modulators of the JNK pathway, they are in particular efficient inhibitors of JNK 2 and 33. The present invention is furthermore related to novel sulfonyl amino acid derivatives as well as to methods of their preparation.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: December 29, 2009
    Assignee: Laboratoires Serono S.A.
    Inventors: Stephen Arkinstall, Serge Halazy, Dennis Church, Montserrat Camps, Thomas Rueckle, Jean-Pierre Gotteland, Marco Biamonte
  • PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES
    Publication number: 20090005426
    Abstract: Sulfonyl hydrazide compounds according to formula I geometrical isomers thereof, optically active enantiomers thereof, diastereomers thereof, racemates thereof, and/or pharmaceutically acceptable salts thereof are useful in method for treating a neuronal disorder, an autoimmune disease, a cardiovascular disease, or cancer in a patient in need of such treatment.
    Type: Application
    Filed: July 14, 2008
    Publication date: January 1, 2009
    Applicant: LABORATOIRES SERONO S.A.
    Inventors: Stephen ARKINSTALL, Serge Halazy, Dennis Church, Montserrat Camps, Thomas Rueckle, Jean-Pierre Gotteland, Marco Biamonte
  • Pharmaceutically active sulfonyl hydrazide derivatives
    Patent number: 7432286
    Abstract: The present invention is related to sulfonyl hydrazide derivatives for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonyl hydrazide derivatives. Said sulfonyl hydrazide derivatives are efficient modulators of the JNK pathway, they are in particular efficient inhibitors of JNK 2 and 3. The present invention is furthermore related to novel sulfonyl hydrazide derivatives as well as to methods of their preparation.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: October 7, 2008
    Assignee: Laboratories Serono SA
    Inventors: Stephen Arkinstall, Serge Halazy, Dennis Church, Montserrat Camps, Thomas Rueckle, Jean-Pierre Gotteland, Marco Biamonte
  • AZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20070293555
    Abstract: The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing various cancers, inflammation, septic shock, preterm labor, infertility, pain, and ischemia, and other diseases and disorders associated with MEK-1 and/or ERK-2 activation.
    Type: Application
    Filed: July 24, 2007
    Publication date: December 20, 2007
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Stephen ARKINSTALL, Antonio Arulanandam, Xuliang Jiang, Sharad Magar, Roustem Nabioullin, John Zhang, Peter Blume-Jensen
  • Methods for Identifying Modulators of Active Kit Tyrosine Kinase Receptor
    Publication number: 20070225202
    Abstract: The present invention relates to cell-based assays useful for screening for modulators, such as inhibitors, of activated mutant KIT tyrosine kinase receptors, which are associated with mast cell-related disorders, such as mastocytosis and various types of cancer. The invention further provides for the treatment of mast cell-related disorders with an inhibitor identified by the screening method.
    Type: Application
    Filed: December 6, 2004
    Publication date: September 27, 2007
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Julian Andreev, Brian Healey, Peter Blume-Jensen, Stephen Arkinstall, Rong Dong
  • INHIBITORS OF PHOSPHODIESTERASES IN INFERTILITY
    Publication number: 20060229288
    Abstract: The present invention is directed to methods of increasing oocyte production in a mammal. More specifically, the specification describes methods and compositions for inducing follicular maturation using a PDE inhibitor. The inhibitor may be used alone at high doses. Alternatively, the follicular maturation is achieved by combining a low dose of FSH with the PDE inhibitor treatment.
    Type: Application
    Filed: February 28, 2006
    Publication date: October 12, 2006
    Inventors: STEPHEN PALMER, SEAN McKENNA, STEPHEN ARKINSTALL, ALIZA ESHKOL, MICHAEL MacNAMEE
  • FSH glycosylation mutant
    Publication number: 20050100989
    Abstract: A novel FSH mutant with increased glycosylation and longer half-lifes for use in inducing folliculogenesis in human patients is described. The FSH mutant permits the use of lower cumulative doses of FSH to achieve the same or better clinical result.
    Type: Application
    Filed: September 2, 2004
    Publication date: May 12, 2005
    Inventors: Louise Garone, Stephen Arkinstall, William Brondyk, Robert Campbell, Xuliang Jiang, Sean McKenna, Mark Tepper
  • Pharmaceutically active compounds and methods of use
    Publication number: 20050054706
    Abstract: The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing various cancers, inflammation, septic shock, preterm labor, infertility, pain, and ischemia, and other diseases and disorders associated with MEK-1 and/or ERK-2 activation.
    Type: Application
    Filed: October 23, 2002
    Publication date: March 10, 2005
    Applicant: Applied Research Systems ARS Holding N.V.
    Inventors: Stephen Arkinstall, Antonio Arulanandam, Xuliang Jiang, Sharad Magar, Roustem Nabioullin, John Zhang, Peter Blume-Jensen