Abstract: Compounds having the structure of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and A are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Menin-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.

Abstract: There is provided a portable apparatus (10) for supporting and carrying a brick structure (22). The portable apparatus (10) includes a base (12) that is configured to carry, in use, the brick structure (22). The portable apparatus (10) also includes a position assembly (14) that has one or more position members (16). The or each position member (16) is configured to define, in use, a first layout for a plurality of bricks of the brick structure (22).

Abstract: There is provided a portable apparatus (10) for supporting and carrying a brick structure (22). The portable apparatus (10) includes a base (12) that is configured to carry, in use, the brick structure (22). The portable apparatus (10) also includes a position assembly (14) that has one or more position members (16). The or each position member (16) is configured to define, in use, a first layout for a plurality of bricks of the brick structure (22).

Abstract: Disclosed is a height adjustable leg for use with furniture, comprising: first and second tubular sections arranged to telescopically couple; an actuator arranged internally to the first and second sections to maintain a selected height; a bearing arranged between the first and second sections to allow smooth relative movement there between and to accommodate manufacturing tolerances.

Abstract: Adjustable furniture support apparatus (10) comprises a support leg (12) and retaining means in the form of retaining member (14) which is arranged to retain a support member (16) to the support leg (12). The support member (16) is arranged to extend radially away from the longitudinal axis of the support leg (12) and the support leg (12) is arranged, in use to be in a substantially vertical plane whilst the support member (16) is arranged to be in a substantially horizontal plane. The support member (16) has a retaining flange (26) defined at a longitudinal end thereof which is arranged, in use, to locate within a retaining groove (24) of a collar provided on the support member in order for the support member to be retained at at selected angle about the longitudinal axis of the support leg (12).

Abstract: A method for recovering hydrocarbon trapped in a hydrate formation, comprising the steps of (a) contacting the hydrate formation with an aqueous solution comprising from 10% to 75% by weight of a salt such as potassium formate or acetate salt to liberate hydrocarbon from the hydrate formation and producing a mixture of hydrocarbon and water vapour; (b) transporting the hydrocarbon/water vapour mixture and the aqueous solution to a separator, whereby the said aqueous solution absorbs water vapour from the mixture during the transportation step, to form a more dilute aqueous solution of the alkali metal salt, thereby inhibiting formation of hydrocarbon hydrates; (c) separating hydrocarbon from said dilute aqueous solution; (d) regenerating the aqueous solution of step (a) by heating said dilute aqueous solution to remove absorbed water vapour; and (f) recycling the regenerated aqueous solution to step (a).

Abstract: A method for recovering hydrocarbon trapped in a hydrate formation, comprising the steps of

Abstract: A modified racing vehicle having dimensions such that it can run on a track suitable for a conventional go-kart and which has substantially the characteristics of a single seater formula racing car. The vehicle has no differential on its rear axle (2) and no suspension on its rear and front axles (5) but is provided with weight transfer structure to compensate therefor. The steering geometry of the vehicle is arranged such that, for the radially outer steerable wheel with reference to a turning centre, a castor angle of the kingpin axis increases and the kingpin axis is inclined into the turn as the steering member (6) pivots and the outer steerable wheel is lifted upwards forcing the chassis (1) down whereby a downward force is exerted through the chassis (1) to a non-steerable wheel (4) that is the radially outer with reference to the turning center.

Abstract: An absorbent for use in absorption refrigeration systems, air conditioning systems, heat pumps or dehumidifiers comprising a solution of potassium formate. The absorbent is relatively non-toxic and relatively non-corrosive towards metals. The absorbent is generally water-based but may also comprise ammonia or methanol. Additives such as corrosion inhibitors or other absorbent salts may be included.