Patents by Inventor Stephen B. Calderwood

Stephen B. Calderwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conjugating amines
    Patent number: 9616139
    Abstract: The disclosure provides directly conjugated polysaccharide vaccine molecules and methods related thereto.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: April 11, 2017
    Assignees: The General Hospital Corporation, The United States, as represented by the secretary, Department of Health and Human Services, International Centre for Diarrhoeal Disease Research, Bangladesh
    Inventors: Edward T. Ryan, Pavol Kovac, Firdausi Qadri, Peng Xu, Stephen B. Calderwood, Willie Frank Vann, Dwight Christopher Peterson
  • CONJUGATING AMINES
    Publication number: 20150031863
    Abstract: The disclosure provides directly conjugated polysaccharide vaccine molecules and methods related thereto.
    Type: Application
    Filed: July 11, 2012
    Publication date: January 29, 2015
    Applicant: The General Hospital Corporation
    Inventors: Edward T. Ryan, Pavol Kovac, Firdausi Qadri, Peng Xu, Stephen B. Calderwood, Willie Frank Vann, Dwight Christopher Peterson
  • Escherichia coli o157:h7 proteins and uses thereof
    Publication number: 20120263724
    Abstract: Immunogenic Escherichia coli O157:H7 (0157) proteins expressed during infection of a mammal, are described. In particular, 0157 proteins expressed specifically in vivo during human and cattle infection were identified. These proteins, mapped to the backbone, O-islands (OIs) and pO157. Because these-proteins are expressed during infection, and might help pathogens adapt to and counter hostile in vivo environments, those proteins identified in this study are useful as targets for drug and vaccine development. Also, such proteins are useful as markers of 0157 infection in stool specimens. Also described are methods of identifying immunogenic proteins.
    Type: Application
    Filed: April 20, 2006
    Publication date: October 18, 2012
    Inventors: Manohar John, Indira T. Kudva, Stephen B. Calderwood, Bryan Krastins, David A. Sarracino
  • IMMUNOGENIC COMPOSITIONS COMPRISING ANTHRAX SPORE-ASSOCIATED PROTEINS
    Publication number: 20090297548
    Abstract: Compositions and methods for treating a Bacillus anthracis infection in a subject in need thereof are provided.
    Type: Application
    Filed: July 19, 2006
    Publication date: December 3, 2009
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Indira T. Kudva, Stephen B. Calderwood, Manohar John
  • Photolyase nucleic acids
    Patent number: 7186816
    Abstract: The invention generally provides a novel approach to identifying Enterococcal virulence factors and for identifying compounds for treating bacterial pathogenesis. The invention further provides Enterococcal virulence factors, which serve as targets for drug discovery.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: March 6, 2007
    Assignee: The General Hospital Corporation
    Inventors: Frederick M. Ausubel, Stephen B. Calderwood, Danielle A. Garsin, Eleftherios Mylonakis, Costi D. Sifri
  • Methods of screening compounds useful for prevention of infection or pathogenicity
    Patent number: 6905670
    Abstract: Screening procedures are disclosed for identifying compounds useful for inhibiting fungal infection or pathogenicity. Methods are also disclosed for identifying fungal pathogenic virulence factors.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: June 14, 2005
    Assignee: The General Hospital Corporation
    Inventors: Frederick M. Ausubel, Stephen B. Calderwood, Eleftherios Mylonakis, Andrew Diener, Julia Plotnikova, Costi D. Sifri, Laurence G. Rahme, Man-Wah Tan, Gary B. Ruvkun, Georg Jander, Jacqueline Heard
  • Enterococcal virulence factors
    Publication number: 20040214208
    Abstract: The invention generally provides a novel approach to identifying Enterococcal virulence factors and for identifying compounds for treating bacterial pathogenesis. The invention further provides Enterococcal virulence factors, which serve as targets for drug discovery.
    Type: Application
    Filed: January 16, 2004
    Publication date: October 28, 2004
    Inventors: Frederick M. Ausubel, Stephen B. Calderwood, Danielle A. Garsin, Eleftherios Mylonakis, Costi D. Sifri
  • Bacterial strain typing
    Publication number: 20040009577
    Abstract: The invention features a method for typing the strain of a bacterial isolate, the method including the steps of: (a) providing genomic DNA from a bacterial isolate; (b) performing a polymerase chain reaction on the genomic DNA using a first and second primer to amplify genomic DNA comprising a restriction nuclease restriction site, thereby producing an amplicon having the restriction site; and (c) characterizing the amplicon of step (b), thereby typing the strain of the bacterial isolate. The invention also features a kit for distinguishing between bacterial strains comprising a set of primer pairs which, when used in a PCR reaction of genomic DNA from a sample of a bacterial isolate amplify DNA across a site for a restriction endonuclease, the amplified DNA being polymorphic between strains of the bacteria.
    Type: Application
    Filed: April 18, 2003
    Publication date: January 15, 2004
    Inventors: Indira Kudva, Stephen B. Calderwood, Frederick M. Ausubel
  • Methods of screening compounds useful for prevention of infection or pathogenicity
    Publication number: 20030086871
    Abstract: Screening procedures are disclosed for identifying compounds useful for inhibiting fungal infection or pathogenicity. Methods are also disclosed for identifying fungal pathogenic virulence factors.
    Type: Application
    Filed: May 22, 2002
    Publication date: May 8, 2003
    Inventors: Frederick M. Ausubel, Stephen B. Calderwood, Eleftherios Mylonakis, Andrew Diener, Julia Plotnikova, Costi D. Sifri, Laurence G. Rahme, Man-Wah Tan, Gary B. Ruvkun, Georg Jander, Jacqueline Heard
  • Screening methods for gram-positive enterococcal virulence factors
    Publication number: 20010028875
    Abstract: Methods are provided for identifying Enterococcal virulence factors. Methods are also provided for screening compounds that inhibit pathogenicity of an Enterococcal pathogen.
    Type: Application
    Filed: February 23, 2001
    Publication date: October 11, 2001
    Inventors: Frederick M. Ausubel, Stephen B. Calderwood, Danielle Garsin, Costi D. Sifri
  • Heterologous antigens in live cell V. cholerae strains
    Patent number: 6036953
    Abstract: Disclosed is a V. cholerae cell containing a DNA encoding a fusion polypeptide that includes a heterologous antigenic polypeptide sequence such as a portion of C. difficile toxin A. The fusion polypeptide also includes one of the following: (i) an E. coli hemolysin A subunit (wich is coexpressed with sequences encoding hemolysin B and D subunits); (ii) a secretion signal sequence and cholera toxin A2 subunit (which is coexpressed with cholera toxin B subunit); or (iii) cholera toxin B subunit.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: March 14, 2000
    Assignee: The General Hospital Corporation
    Inventors: Edward T. Ryan, Stephen B. Calderwood
  • Immunizing compositions comprising Vibrio cholerae expressing heterologous antigens
    Patent number: 5747028
    Abstract: A bacterial cell (preferably a gram-negative, enteric bacterium such as V. cholerae) the chromosome of which which contains a DNA sequence encoding a heterologous antigen, which sequence is functionally linked to an iron-regulated promoter such as the irgA promoter of V. cholerae.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 5, 1998
    Assignee: The President and Fellows of Harvard College
    Inventors: Stephen B. Calderwood, Joan R. Butterton, John J. Mekalanos