Patents by Inventor Stephen B. Fleming

Stephen B. Fleming has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vascular endothelial growth factor-like protein from ORF viruses binds and activates mammalian VEGF receptor-2, and uses thereof
    Publication number: 20030211101
    Abstract: The invention is based on the discovery that a viral VEGF-like protein from the orf virus strain NZ2 and from the orf virus strain NZ10 is capable of binding to the extracellular domain of the VEGF receptor-2 to form bioactive complexes which mediate useful cellular responses and/or antagonize undesired biological activities. Disclosed are methods which stimulate or inhibit these biological activities, methods for therapeutic applications and antagonists of ORFV2-VEGF and/or NZ10.
    Type: Application
    Filed: January 28, 2003
    Publication date: November 13, 2003
    Inventors: Lyn M. Wise, Andrew A. Mercer, Loreen J. Savory, Stephen B. Fleming, Steven A. Stacker
  • Vascular endothelial growth factor-like protein from orf viruses binds and activates mammalian VEGF receptor-2, and uses thereof
    Patent number: 6541008
    Abstract: The invention is based on the discovery that a viral VEGF-like protein from the orf virus strain NZ2 and from the orf virus strain NZ10 is capable of binding to the extracellular domain of the VEGF receptor-2 to form bioactive complexes which mediate useful cellular responses and/or antagonize undesired biological activities. Disclosed are methods which stimulate or inhibit these biological activities, methods for therapeutic applications and antagonists of ORFV2-VEGF and/or NZ10.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: April 1, 2003
    Assignees: University of Otago, Ludwig Institute for Cancer Research
    Inventors: Lyn M. Wise, Andrew A. Mercer, Loreen J. Savory, Stephen B. Fleming, Steven A. Stacker