Patents by Inventor Stephen B. Haber

Stephen B. Haber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging
    Patent number: 11865195
    Abstract: The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety. The invention further provides methods for evaluating the presence of the risk of developing other cardiovascular conditions and assessing the effectiveness of treatment or other intervention for such conditions by determining MMP levels.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: January 9, 2024
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Albert J. Sinusas, Joseph G. Akar, Richard R. Cesati, Heike S. Radeke, Stephen B. Haber
  • EVALUATION OF PRESENCE OF AND VULNERABILITY TO ATRIAL FIBRILLATION AND OTHER INDICATIONS USING MATRIX METALLOPROTEINASE-BASED IMAGING
    Publication number: 20200390912
    Abstract: The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety. The invention further provides methods for evaluating the presence of the risk of developing other cardiovascular conditions and assessing the effectiveness of treatment or other intervention for such conditions by determining MMP levels.
    Type: Application
    Filed: May 22, 2020
    Publication date: December 17, 2020
    Applicants: Lantheus Medical Imaging, Inc., Yale University
    Inventors: Albert J. Sinusas, Joseph G. Akar, Richard R. Cesati, Heike S. Radeke, Stephen B. Haber
  • EVALUATION OF PRESENCE OF AND VULNERABILITY TO ATRIAL FIBRILLATION AND OTHER INDICATIONS USING MATRIX METALLOPROTEINASE-BASED IMAGING
    Publication number: 20180177901
    Abstract: The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety. The invention further provides methods for evaluating the presence of the risk of developing other cardiovascular conditions and assessing the effectiveness of treatment or other intervention for such conditions by determining MMP levels.
    Type: Application
    Filed: October 2, 2017
    Publication date: June 28, 2018
    Applicants: Lantheus Medical Imaging, Inc., Yale University
    Inventors: Albert J. Sinusas, Joseph G. Akar, Richard R. Cesati, Heike S. Radeke, Stephen B. Haber
  • EVALUATION OF PRESENCE OF AND VULNERABILITY TO ATRIAL FIBRILLATION AND OTHER INDICATIONS USING MATRIX METALLOPROTEINASE-BASED IMAGING
    Publication number: 20150023873
    Abstract: The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety. The invention further provides methods for evaluating the presence of the risk of developing other cardiovascular conditions and assessing the effectiveness of treatment or other intervention for such conditions by determining MMP levels.
    Type: Application
    Filed: October 31, 2012
    Publication date: January 22, 2015
    Applicants: Lantheus Medical Imaging, Inc., Yale University
    Inventors: Albert J. Sinusas, Joseph G. Akar, Richard R. Cesati, Heike S. Radeke, Stephen B. Haber
  • LABELED PE2I FORMULATION AND METHOD
    Publication number: 20140079634
    Abstract: A diagnostic formulation is provided comprising a tropane having a radioactive concentration of at least 1.6 mCi/mL at least about 51 hours post creation. The diagnostic formulation optionally comprises a radiolabeled dopamine transporter (DAT) ligand useful in the diagnosis of Parkinson's disease (PS). One example of a radiolabeled dopamine transporter (DAT) ligand example is [123I]-N-(3-iodoprop-2E-enyl)-2?-carbomethoxy-3?-(4-methylphenyl) nortropane.
    Type: Application
    Filed: September 13, 2013
    Publication date: March 20, 2014
    Applicant: NAVIDEA BIOPHARMACEUTICALS INC.
    Inventors: Stephen B. Haber, Richard Thorn
  • 2,3-diaryl-5-bromothiophene compounds of use for the treatment of inflammaton and dysmenorrhea
    Patent number: 4820827
    Abstract: A small group of 2,3-diaryl-5-bromothiophene compounds such as 5-bromo-2-(4-methylthiophenyl)-3-(4-fluorophenyl)thiophene have been found to possess significant and unexpected antiinflammatory activity, and inhibition of prostaglandin synthetase useful for the treatment of arthritis and dysmenorrhea.
    Type: Grant
    Filed: February 10, 1984
    Date of Patent: April 11, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Stephen B. Haber
  • Antiinflammatory and/or analgesic 5-alkylthiophenes
    Patent number: 4749712
    Abstract: 5-Alkyl-2,3-diarylthiophenes, such as 5-(1,1-dimethylethyl)-2,3-bis(4-methoxyphenyl)thiophene, 5-(1-methylpropyl)-2,3-bis(4-methoxyphenyl)thiophene and 5-cyclohexyl-2,3-bis(4-methoxyphenyl)thiophene, are useful in the treatment of inflammation and/or pain.
    Type: Grant
    Filed: December 5, 1984
    Date of Patent: June 7, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Stephen B. Haber
  • Antiinflammatory and/or analgesic 2,3-diaryl-5-halo thiophenes
    Patent number: 4590205
    Abstract: Certain 2,3-diaryl-5-halo thiophenes are useful in the treatment of inflammation and/or pain.
    Type: Grant
    Filed: January 17, 1984
    Date of Patent: May 20, 1986
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Stephen B. Haber
  • Antiinflammatory and/or analgesic silylfurans
    Patent number: 4500520
    Abstract: Silyldiarylfurans, such as 4,5-bis(4-methoxyphenyl)-2-trimethylsilylfuran, are useful in the treatment of inflammation and/or pain.
    Type: Grant
    Filed: March 1, 1983
    Date of Patent: February 19, 1985
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Stephen B. Haber
  • Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes
    Patent number: 4432974
    Abstract: 2,3-Diaryl-5-silyl thiophenes, such as 2,3-bis(4-methoxyphenyl)-5-(trimethylsilyl)thiophene; 2,3-bis(4-methoxyphenyl)-5-(ethenyldimethylsilyl)thiophene; and 2,3-bis(4-methoxyphenyl)-5-[(2-propenyl)dimethylsilyl]-thiophene, are useful in the treatment of inflammation and/or pain.
    Type: Grant
    Filed: March 4, 1982
    Date of Patent: February 21, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Stephen B. Haber
  • Antiinflammatory 4,5-diaryl-.alpha.,.alpha.-bis (polyhalomethyl)-2-thiophenemethanamines
    Patent number: 4427693
    Abstract: 4,5-Diaryl-.alpha.,.alpha.-bis(polyhalomethyl)-2-thiophene-methanamines, such as 4,5-bis(4-fluorophenyl)-.alpha.,.alpha.-bis-(trifluoromethyl)-2-thiophenem ethanamine, useful for treating arthritis and/or alleviating pain.
    Type: Grant
    Filed: November 2, 1981
    Date of Patent: January 24, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Stephen B. Haber
  • Antiinflammatory 4,5-diaryl-.alpha.-(polyhalomethyl)-2-thiophenemethanols
    Patent number: 4381311
    Abstract: 4,5-Diaryl-.alpha.-(polyhalomethyl)-2-thiophenemethanols such as 4-(4-methoxyphenyl)-5-(4-methylthiophenyl)-.alpha.,.alpha.-bis(trifluorome thyl)-2-thiophenemethanol useful for treating arthritis and/or alleviating pain.
    Type: Grant
    Filed: August 27, 1981
    Date of Patent: April 26, 1983
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Stephen B. Haber