Patents by Inventor Stephen B. Thomas

Stephen B. Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating infections
    Patent number: 11530198
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: December 20, 2022
    Assignee: Vyera Pharmaceuticals, LLC
    Inventors: Stephen B. Thomas, Allen T. Hopper, Matthew Welsch
  • Nucleic acid prodrugs
    Patent number: 11479576
    Abstract: The invention relates to a method of treating a mitochondrial DNA depletion syndrome, comprising administering to a patient a therapeutically-effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: October 25, 2022
    Assignee: AVALO THERAPEUTICS, INC.
    Inventors: Stephen B. Thomas, Patrick J. Crutcher
  • NUCLEOTIDE PRODRUGS
    Publication number: 20210139525
    Abstract: The invention relates to nucleotide prodrugs and pharmaceutical preparations thereof. The invention further relates using the prodrugs of the invention in the treatment of mitochondrial DNA (mtDNA) depletion syndrome (MDS).
    Type: Application
    Filed: January 7, 2019
    Publication date: May 13, 2021
    Inventors: Stephen B. Thomas, Patrick J. Crutcher, Fabrizio Pertusati, Elisa Pileggi
  • NUCLEIC ACID PRODRUGS
    Publication number: 20210101923
    Abstract: The invention relates to nucleotide prodrugs and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel prodrugs of the invention.
    Type: Application
    Filed: June 19, 2020
    Publication date: April 8, 2021
    Inventors: Stephen B. Thomas, Patrick J. Crutcher
  • COMPOSITIONS AND METHODS FOR TREATING INFECTIONS
    Publication number: 20200407345
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: September 10, 2020
    Publication date: December 31, 2020
    Inventors: Stephen B. Thomas, Allen T. Hopper, Matthew Welsch
  • Compositions and methods for treating infections
    Patent number: 10774073
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: September 15, 2020
    Assignee: Vyera Pharmaceuticals, LLC
    Inventors: Stephen B. Thomas, Allen T. Hopper, Matthew Welsch
  • DHFR INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO
    Publication number: 20200270233
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: August 6, 2018
    Publication date: August 27, 2020
    Inventors: Allen T. Hopper, Stephen B. Thomas, Mattthew Welsch
  • Nucleic acid prodrugs
    Patent number: 10745435
    Abstract: The invention relates to deoxynucleotide prodrugs and pharmaceutical preparations thereof. The deoxynucleotide prodrugs include, but are not limited to, The invention further relates to methods of treatment of a mitochondrial DNA (mtDNA) depletion syndrome (MDS) by administering a therapeutically-effective amount of a deoxynucleotide prodrug of the present invention.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: August 18, 2020
    Assignee: CERECOR, INC.
    Inventors: Stephen B. Thomas, Patrick J. Crutcher
  • NUCLEIC ACID PRODRUGS
    Publication number: 20180346508
    Abstract: The invention relates to nucleotide prodrugs and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel prodrugs of the invention.
    Type: Application
    Filed: November 16, 2016
    Publication date: December 6, 2018
    Inventors: Stephen B. Thomas, Patrick J. Crutcher
  • Curved diverter plate assembly for interchangeability of various models of traveling water screens
    Patent number: 4892652
    Abstract: A traveling water screen of the dual flow type is provided with diverter plates having projections on the diverter plates that allow the dual flow water screen to be restrained in position when inserted into compatible channels in a host sluice channel.
    Type: Grant
    Filed: July 22, 1988
    Date of Patent: January 9, 1990
    Assignee: FMC Corporation
    Inventors: Douglas W. Rudy, Michael P. Hunnemann, Stephen B. Thomas