Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: Various embodiments are disclosed for improved and structurally optimized transistors, such as RF power amplifier transistors. A transistor may include a drain metal portion raised from a surface of a substrate, a drain metal having a notched region, a gate manifold body with angled gate tabs extending from the gate manifold, and/or a source-connected shielding. The transistor may include a high-electron-mobility transistor (HEMT), a gallium nitride (GaN)-on-silicon transistor, a GaN-on-silicon-carbide transistor, or other type of transistor.

Abstract: A process for generating a response message to an eligibility verification request transmitted over a healthcare claims network having at least one health care protocol of communication comprises the steps of: executing business rules on a rules engine for a program sponsor on information in the eligibility verification request to determine an individual's eligibility for benefits; generating a protocol-compliant response message including information not specified in the health care protocol of communication; and providing the protocol-compliant response message to the claims network; wherein the at least one health care protocol of communication comprises the NCPDP Telecommunication Standard.

Abstract: A method includes selecting, from a database, messages of a first electronic control (ECU) unit according to a specified datum that the first ECU is programmed to provide via a communications bus, generating a first file of the messages of the first ECU, sorting the messages in the first file according to a hierarchy that includes the specified datum, and outputting a third file describing a comparison of the first file and a second file that includes messages of a second ECU.

Abstract: A method includes selecting, from a database, messages of a first electronic control (ECU) unit according to a specified datum that the first ECU is programmed to provide via a communications bus, generating a first file of the messages of the first ECU, sorting the messages in the first file according to a hierarchy that includes the specified datum, and outputting a third file describing a comparison of the first file and a second file that includes messages of a second ECU.

Abstract: A non-contact optical probe for inspecting the surface of a workpiece includes: a laser source that emits an incident beam of light, an optical system that focuses the optical beam and directs the focused incident beam onto the surface being inspected, a mechanism for scanning the focused beam across the surface being inspected by moving the focal point of the beam relative to the surface, an encoder system that tracks the location of the focused beam on the surface as a function of position, and a wavelength filter that prevents scattered and reflected laser radiation and ambient visible light from reaching an infrared detector inside the probe. The probe design also prevents infrared radiation from locations other than the spot illuminated by the focused laser beam from reaching the detector.

Abstract: A cellular communication system is described for supporting broadcast transmission in at least one of a plurality of communication cells. The cellular communication system comprises at least one base station (210) capable of broadcasting content to at least one wireless communication unit (226) via at least one relay node (RN) (224), wherein the at least one base station (210) is arranged to supplement the broadcast transmission with at least one augmented unicast transmission associated with the broadcast content.

Abstract: A battery charge management method and device operable to perform that method. The battery charge management method comprises the steps of determining charge delivered to or from a battery based on Coulomb counting and updating an estimated battery state of charge based on the amount of delivered charge and measuring the battery current. Then comparing the updated estimated battery state of charge with a predetermined state of charge value of less than 100%, such that each predetermined state of charge value being associated with an expected battery current for that predetermined state of charge value. The method also includes modifying the updated estimated battery state of charge when the updated estimated state of charge is greater than the predetermined state of charge value and the measured battery current is greater than the expected battery current associated with the predetermined state of charge.

Abstract: A mobile communications network includes plural base stations in a network and configured to transmit to mobile communications devices a broadcast signal providing a sequence of data blocks in a sequence of transmission frames, each data block of the sequence being transmitted by each of the base stations contemporaneously for each of the sequence of transmission frames. One or more relay nodes are configured to receive the broadcast signal transmitted by one of the base stations and retransmit the broadcast signal, as the sequence of data blocks in the sequence of transmission frames on the same frequency as the broadcast signal transmitted by the base station, so that one or more of the mobile communications devices can receive the broadcast signal and recover the sequence of data blocks from one or both of the broadcast signal transmitted by the base station or the broadcast signal transmitted by the relay node.

Abstract: A non-contact optical probe for inspecting an inside surface of a cylindrical workpiece includes a laser source that emits an incident light beam, a polarizing beam splitter that transmits one polarization of the incident beam and reflects the opposite polarization, and a quarter wave plate that together with the polarizing beam splitter separates back reflected return light from the incident laser beam. The non-contact optical probe further includes an optical system that directs the incident laser beam onto the cylinder surface and directs reflected light from the surface back to the beam splitter, and at least one detector that receives a portion of the reflected light and generates data about the cylinder surface.

Abstract: A fusion pipe assembly includes a fitting having at least one open end with a fusion region. A fusion pipe has a proximal end with a fusion region so that when the proximal end is inserted into the at least one open end, the fusion regions can be fused together. The fusion pipe has a distal end for mechanically coupling in a pipe network. A collar is inserted in the distal end and has an outer diameter approximately equal to an inner diameter of the distal end so that the collar strengthens the distal end. Preferably, the collar extends into the at least one open end of the fitting.

Abstract: A method for supporting broadcast transmission in a wireless communication system (200) that comprises a plurality of communication cells, with broadcast content being routed from a base station (210) to at least one wireless communication unit (225, 226) via at least one relay node (RN) (224) is described. The method comprises, at the base station (210) broadcasting the broadcast content from the base station (210) to at least one from a group consisting of: the at least one RN (224), the at least one wireless communication unit (226); and supplementing the broadcast transmission with at least one augmented unicast transmission associated with the broadcast content. A base station (210), an integrated circuit and a non-transitory computer program product comprising executable program code are also described. A relay node (224), an integrated circuit, a method performed at the relay node and a non-transitory computer program product comprising executable program code are also described.

Abstract: Variants of factor IX with increased membrane binding affinity, and the use of such variants for treating factor IX deficiency, are described.

Abstract: A non-contact optical probe for inspecting an inside surface of a cylindrical workpiece includes a laser source that emits an incident light beam, a polarizing beam splitter that transmits one polarization of the incident beam and reflects the opposite polarization, a quarter wave plate that together with the polarizing beam splitter separates back reflected return light from the incident laser beam, a probe tip that directs the incident laser beam onto the cylinder surface and directs reflected light from the surface back to the beam splitter, and at least one detector that receives a portion of the reflected light and generates data about the cylinder surface.

Abstract: A mobile device may communicate through multiple access point names (APNs) through wireless local area network (WLAN) protocols. The APNs are data routes that may be accessible to a device through other non-WLAN networks (e.g. cellular), but can be accessed with a WLAN device through WLAN protocols. A sub network access protocol (SNAP) header may be modified and used for routing traffic.

Abstract: A mobile communications network includes plural base stations in a network and configured to transmit to mobile communications devices a broadcast signal providing a sequence of data blocks in a sequence of transmission frames, each data block of the sequence being transmitted by each of the base stations contemporaneously for each of the sequence of transmission frames. One or more relay nodes are configured to receive the broadcast signal transmitted by one of the base stations and retransmit the broadcast signal, as the sequence of data blocks in the sequence of transmission frames on the same frequency as the broadcast signal transmitted by the base station, so that one or more of the mobile communications devices can receive the broadcast signal and recover the sequence of data blocks from one or both of the broadcast signal transmitted by the base station or the broadcast signal transmitted by the relay node.

Abstract: A mobile device may communicate through multiple access point names (APNs) through wireless local area network (WLAN) protocols. The APNs are data routes that may be accessible to a device through other non-WLAN networks (e.g. cellular), but can be accessed with a WLAN device through WLAN protocols. A sub network access protocol (SNAP) header may be modified and used for routing traffic.

Abstract: The present application describes an arrangement for applying a label to the periphery of a moving object. The arrangement may include an initial label dispensing an application station, a label tacking station, and a label wrapping station. Associated methods are also described.

Abstract: Modifications of vitamin K-dependent polypeptides that lead to enhanced protein function on a weight or molar basis and/or increase of protein lifetime in the circulation are described. Both objectives are important for using vitamin K-dependent polypeptides for pro- and anti-coagulation therapies, as well as for other uses in the circulation.

Abstract: A cellular communication system is described for supporting broadcast transmission in at least one of a plurality of communication cells. The cellular communication system comprises at least one base station (210) capable of broadcasting content to at least one wireless communication unit (226) via at least one relay node (RN) (224), wherein the at least one base station (210) is arranged to supplement the broadcast transmission with at least one augmented unicast transmission associated with the broadcast content.