Patents by Inventor Stephen Bellum

Stephen Bellum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Copper-dependent non-traditional pro-inflammatory cytokine export and methods, compositions and kits relating thereto
    Publication number: 20090123565
    Abstract: The present invention relates to the discovery that non-traditional export of certain pro-inflammatory cytokines lacking a signal sequence from a cell can be inhibited by copper chelation and/or administration to the cell of a truncated form of S100A13 lacking the basic residue portion. Further, copper chelation inhibits, inter alia, neointima formation, macrophage infiltration and associated inflammation, cell proliferation, secretion of extracellular matrix, intimal thickening, adventitial angiogenesis, restenosis, and the like, associated with vascular vessel injury. Thus, the present invention provides novel methods of preventing and treating, and for identifying novel compounds also useful as therapeutics for, such conditions.
    Type: Application
    Filed: May 22, 2006
    Publication date: May 14, 2009
    Inventors: Thomas Maciag, Lorraine Maciag, Anna Mandinova, Lazar Mandinov, Igor Prudovsky, Stephen Bellum, Raffaella Soldi, Cinzia Bagala
  • Copper-dependent non-traditional pro-inflammatory cytokine export and methods, compositions and kits relating thereto
    Publication number: 20060210647
    Abstract: The present invention relates to the discovery that non-traditional export of certain pro-inflammatory cytokines lacking a signal sequence from a cell can be inhibited by copper chelation and/or administration to the cell of a truncated form of S100A13 lacking the basic residue portion. Further, copper chelation inhibits, inter alia, neointima formation, macrophage infiltration and associated inflammation, cell proliferation, secretion of extracellular matrix, intimal thickening, adventitial angiogenesis, restenosis, and the like, associated with vascular vessel injury. Thus, the present invention provides novel methods of preventing and treating, and for identifying novel compounds also useful as therapeutics for, such conditions.
    Type: Application
    Filed: May 22, 2006
    Publication date: September 21, 2006
    Inventors: Thomas Maciag, Lorraine Maciag, Anna Mandinova, Lazar Mandinov, Igor Prudovsky, Stephen Bellum, Raffaella Soldi, Cinzia Bagala
  • Copper-dependent non-traditional pro-inflammatory cytokine export and methods, compositions and kits relating thereto
    Publication number: 20040229796
    Abstract: The present invention relates to the discovery that non-traditional export of certain pro-inflammatory cytokines lacking a signal sequence from a cell can be inhibited by copper chelation and/or administration to the cell of a truncated form of S100A13 lacking the basic residue portion. Further, copper chelation inhibits, inter alia, neointima formation, macrophage infiltration and associated inflammation, cell proliferation, secretion of extracellular matrix, intimal thickening, adventitial angiogenesis, restenosis, and the like, associated with vascular vessel injury. Thus, the present invention provides novel methods of preventing and treating, and for identifying novel compounds also useful as therapeutics for, such conditions.
    Type: Application
    Filed: February 23, 2004
    Publication date: November 18, 2004
    Applicant: Maine Medical Center Research Institute
    Inventors: Thomas Maciag, Anna Mandinova, Lazar Mandinov, Igor Prudovsky, Stephen Bellum, Raffaella Soldi, Cinzia Bagala