Patents by Inventor Stephen Benkovic

Stephen Benkovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation of alkyl diaryl borinates and complexed diarylboronic acids
    Publication number: 20050080048
    Abstract: The present invention provides methods for preparing complexed diaryl boronic acids from alkyl diarylborinates.
    Type: Application
    Filed: January 9, 2003
    Publication date: April 14, 2005
    Inventors: Ali Tavassoli, Stephen Benkovic
  • Antibiotics containing borinic acid complexes and methods of use
    Publication number: 20050070503
    Abstract: The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
    Type: Application
    Filed: June 14, 2004
    Publication date: March 31, 2005
    Inventors: Ving Lee, Stephen Benkovic, Stephen Baker, Kirk Maples, Tsutomu Akama, Yong-Kang Zhang, Rajeshwar Singh, Vittorio Sauro, Chetan Pandit, Zhuoyi Su, Zhixiang Yang
  • Hydrolytically-resistant boron-containing therapeutics and methods of use
    Publication number: 20050054644
    Abstract: Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
    Type: Application
    Filed: June 15, 2004
    Publication date: March 10, 2005
    Inventors: Ving Lee, Jacob Plattner, Stephen Benkovic, Stephen Baker, Kirk Maples, Carolyn Bellinger-Kawahara, Tsutomu Akama, Yong-Kang Zhang, Rajeshwar Singh, Vittorio Sauro
  • Stereoisomer separation method using antibody combing site-containing molecules
    Patent number: 5248611
    Abstract: A method of separating a pair of stereoisomers, and especially enantiomers, using monoclonal receptor molecules containing an antibody combining site that binds to substantially only one of that pair of stereoisomers is disclosed.
    Type: Grant
    Filed: January 3, 1992
    Date of Patent: September 28, 1993
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Stephen Benkovic, Richard Lerner, Alfonso Tramontano, Andrew D. Napper
  • Antibody combining sites that exhibit stereoselective synthase activity, and methods using the same
    Patent number: 5079152
    Abstract: A phosphorus-containing analog-ligand having a stereoconfiguration that substantially corresponds to the stereoconfiguration of an amide- or ester-forming transition state is used to induce production of receptor molecules whose antibody combining sites have stereospecific amide or ester synthase catalytic activity when reacted with a ligand containing (i) a carbonyl carbon atom and (ii) an amine or alcohol group that are structurally capable of forming a preselected stereoisomer of a carboxylic amide or ester.
    Type: Grant
    Filed: August 7, 1987
    Date of Patent: January 7, 1992
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Stephen Benkovic, Richard A. Lerner, Alfonso Tramontano, Andrew D. Napper
  • Antibody combining sites that exhibit amide or ester synthase activity
    Patent number: 4900674
    Abstract: A phosphorous-containing analog-ligand having a conformation that substantially corresponds to the conformation of an amide- or ester-forming transition state is used to induce production of receptor molecules whose antibody combining sites have amide or ester synthase catalytic activity when reacted with a ligand containing (i) a carbonyl carbon atom and (ii) an amine or alcohol group that are structurally capable of forming a preselected carboxylic amide or ester bond.
    Type: Grant
    Filed: May 28, 1987
    Date of Patent: February 13, 1990
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Stephen Benkovic, Richard A. Lerner, Alfonso Tramontano, Andrew D. Napper