Abstract: Disclosed is the use of mammalian target of rapamycin (mTOR) and/or phosphoinositide-3-kinase (PI3K) inhibitors as antiparasitic drugs, particularly in those parasitic infections caused by trypanosomatid parasites {Trypanosoma sp. and Leishmania sp.). These inhibitors are useful as trypanocides.

Abstract: Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.

Abstract: For paints and the like, an aqueous tinter which does not block dispensing nozzles and which has a viscosity of from 0.05 to 1.5 Ns/m.sup.2 (20.degree. C.) and which contains pigment particles, water, micellising dispersant and a non-micellising auxiliary material. The weight ratio of dispersant to pigment must exceed the ratio which would be present at the Daniel Flow Point for a notional tinter consisting only of the pigment, water and the dispersant. The amount of auxiliary material must be sufficient to enable the tinter to be expelled through a bore 2 mm in diameter and 15 mm long by a pressure of not more than 320 MN/m.sup.2 after storage in the bore at 25.degree. C. for 18 hours under a relative humidity of 50%. Preferred dispersants comprise long chain hydrophilic and long chain hydrophobic moieties which may be poly(alkylene glycol) esters of long chain fatty acids or hydrophobic backbone copolymers with pendant poly(alkylene glycol) moieties as hydrophilic side chains.