Abstract: The subject invention provides compounds as Drp1 inhibitors, compositions comprising a Drp1 inhibitor, and methods for inhibiting Drp1 protein using the Drp1 inhibitors. Further provided are methods for treating and/or preventing a disease or condition associated with mitochondrial dysfunction, oxidative stress, inflammation and/or autophagy. Advantageously, the compounds and compositions of the subject invention can also be used to treat a variety of other conditions including, for example, autoimmune disorders, disorders of the nervous system, and cardiovascular disorders.

Abstract: A system includes a processor and a memory. When executed by the processor, the processor is caused to receive a first file including one or more components, parse the first file into a metadata portion and one or more non-metadata portions, generate a manifest for each of the one or more non-metadata portions, generate an output data stream including component manifest and data pairs for each of the one or more non-metadata portions, normalize the output data stream, generate a first hash code corresponding to the normalized output data stream and compare the first hash code to a plurality of hash codes. If the first hash code matches any hash code of the plurality of hash codes, the processor is caused to prevent the first file from being stored in the database or automatically remove the corresponding file associated with the hash code matched with the first hash code.

Abstract: The subject invention provides compounds as Drp1 inhibitors, compositions comprising a Drp1 inhibitor, and methods for inhibiting Drp1 protein using the Drp1 inhibitors. Further provided are methods for treating and/or preventing a disease or condition associated with mitochondrial dysfunction, oxidative stress, inflammation and/or autophagy. Advantageously, the compounds and compositions of the subject invention can also be used to treat a variety of other conditions including, for example, autoimmune disorders, disorders of the nervous system, and cardiovascular disorders.

Abstract: To provide a technique for evaluating a shape that appears in a cross-sectional image, one of the typical evaluation methods of the present invention evaluates a difference between a target shape and a cross-sectional shape of an electron microscopic image, and includes: a first step of measuring a characteristic dimension of the cross-sectional shape; after the first step, a second step of creating a template of the target shape in the cross-sectional shape obtained from the dimension; and a third step of comparing a difference between the template and the cross-sectional shape using a normalized metric.

Abstract: The subject invention provides compounds as Drp1 inhibitors, compositions comprising a Drp1 inhibitor, and methods for inhibiting Drp1 protein using the Drp1 inhibitors. Further provided are methods for treating and/or preventing a disease or condition associated with mitochondrial dysfunction, oxidative stress, inflammation and/or autophagy. Advantageously, the compounds and compositions of the subject invention can also be used to treat a variety of other conditions including, for example, autoimmune disorders, disorders of the nervous system, and cardiovascular disorders.

Abstract: The subject invention provides compounds as Drp1 inhibitors, compositions comprising a Drp1 inhibitor, and methods for inhibiting Drp1 protein using the Drp1 inhibitors. Further provided are methods for treating and/or preventing a disease or condition associated with mitochondrial dysfunction, oxidative stress, inflammation and/or autophagy. Advantageously, the compounds and compositions of the subject invention can also be used to treat a variety of other conditions including, for example, autoimmune disorders, disorders of the nervous system, and cardiovascular disorders.

Abstract: Provided herein are compositions and methods for treating respiratory and pulmonary vascular disease. In particular, provided herein are spray dried simvastatin for delivery to the lung.

Abstract: Provided herein are compositions and methods for treating pulmonary hypertension. In particular, provided herein are dry powder formulations of fasudil for delivery to the lung.

Abstract: A dual fuel burner system includes a fuel burner housing and a main fuel supply conduit within the fuel burner housing. A main fuel nozzle is positioned proximate to a downstream end of the fuel burner housing and is in fluid communication with the main fuel supply conduit. The main fuel supply conduit is configured to provide 100% of the heat input requirement of the dual fuel burner system. A secondary fuel supply conduit is within the fuel burner housing. The secondary fuel supply conduit is configured to provide 100% of the heat input requirement of the dual fuel burner system. An air circuit is in fluid communication with an outlet of the main fuel nozzle. A direct spark ignitor is positioned proximate to the outlet of the main fuel nozzle.

Abstract: Provided herein are compositions and methods for treating pulmonary hypertension. In particular, provided herein are dry powder formulations of fasudil for delivery to the lung.

Abstract: Simulation of execution of a processing workload by a target hardware device is provided by providing workload data specifying the processing workload, passing the workload data to both a primary partial simulation and a complementary partial simulation that run in parallel and acquire input data from different levels of abstraction of the target hardware and then simulating execution of the processing workload using a primary partial simulation to generate primary partial result state data and using the complementary partial simulation to generate complementary partial result state data. The target hardware device may be a graphics processing unit and the workload data may specify the processing to be performed in a hardware independent form, such as, for example, OpenGL ES. The host system supporting the simulation may include a graphics processing unit serving to provide the complementary partial simulation due to its own execution of the workload data.

Abstract: Provided herein are compositions and methods for treating respiratory and pulmonary vascular disease. In particular, provided herein are spray dried simvastatin for delivery to the lung.

Abstract: A wall-fired burner includes a fuel tip defining a fuel direction axis and a fuel tip pivot axis perpendicular thereto. A first air tip is adjacent to the fuel tip. The first air tip defines a first air direction axis and a first air tip pivot axis perpendicular thereto. A second air tip is adjacent to the fuel tip, opposite from the first air tip across the fuel tip. The second air tip defines a second air direction axis and a second air tip pivot axis perpendicular thereto. A mechanism operatively connects the fuel tip, the first air tip and the second air tip for at least one of independent and/or joint movement of the fuel tip, the first air tip and the second air tip.

Abstract: A dual fuel burner system includes a fuel burner housing and a main fuel supply conduit within the fuel burner housing. A main fuel nozzle is positioned proximate to a downstream end of the fuel burner housing and is in fluid communication with the main fuel supply conduit. The main fuel supply conduit is configured to provide 100% of the heat input requirement of the dual fuel burner system. A secondary fuel supply conduit is within the fuel burner housing. The secondary fuel supply conduit is configured to provide 100% of the heat input requirement of the dual fuel burner system. An air circuit is in fluid communication with an outlet of the main fuel nozzle. A direct spark ignitor is positioned proximate to the outlet of the main fuel nozzle.

Abstract: A wall-fired burner includes a fuel tip defining a fuel direction axis and a fuel tip pivot axis perpendicular thereto. A first air tip is adjacent to the fuel tip. The first air tip defines a first air direction axis and a first air tip pivot axis perpendicular thereto. A second air tip is adjacent to the fuel tip, opposite from the first air tip across the fuel tip. The second air tip defines a second air direction axis and a second air tip pivot axis perpendicular thereto. A mechanism operatively connects the fuel tip, the first air tip and the second air tip for at least one of independent and/or joint movement of the fuel tip, the first air tip and the second air tip.

Abstract: Simulation of execution of a processing workload by a target hardware device is provided by providing workload data specifying the processing workload, passing the workload data to both a primary partial simulation and a complementary partial simulation that run in parallel and acquire input data from different levels of abstraction of the target hardware and then simulating execution of the processing workload using a primary partial simulation to generate primary partial result state data and using the complementary partial simulation to generate complementary partial result state data. The target hardware device may be a graphics processing unit and the workload data may specify the processing to be performed in a hardware independent form, such as, for example, OpenGL ES. The host system supporting the simulation may include a graphics processing unit serving to provide the complementary partial simulation due to its own execution of the workload data.

Abstract: A stationery form is provided with adhesive regions that do not adhere to each other until the adhesive has been activated. The adhesive is heat activated without melting by passage through a laser printer prior to folding the printed form about at least one crease line to secure the form in a folded position.

Abstract: A tamper-evident stationery form for transmitting confidential information to a user comprises a single a single sheet of paper of rectangular shape foldable about first and second fold lines to position a first panel between two outer panels in a folded condition of the form. The panels are provided with adhesive regions for securing marginal edge regions of adjacent panels to each other in the folded condition, and the first panel and one of the two outer panels are provided with adhesive regions inboard of the marginal edge regions which form a pocket within the form in the folded condition. The first panel has a flap that is concealed by the other of the two outer panels in the folded condition and the panels are provided with perforate regions for removing the marginal edge regions to open the form without opening the pocket. The flap is at least partially separable from the first panel to reveal a printable area within the pocket on which confidential information may be provided when the form is opened.

Abstract: An improved process and method for lifecycle digital maturity assessment, including process evaluation and ranking, and the creation of recommendations.

Abstract: A stationery form including a single sheet of printable material that has a self-seal contact adhesive applied to edge regions arranged to contact each other when the form is folded about a crease line. Contacting edge regions are releasably adhered when a first pressure is applied to seal temporarily the form in a folded condition such that the form can be opened and re-sealed. The contacting edge regions are non-releasably adhered when a second pressure higher than the first pressure is applied to seal permanently the form in the folded condition. Low pressure sealing may be achieved manually, for example by finger pressure. High pressure sealing may be provided with a pressure sealing machine. A permanently sealed form can be opened by tearing along lines of weakness inboard of the adhesive to remove the bonded regions.