Patents by Inventor Stephen Blacklow

Stephen Blacklow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RAP variants for drug delivery and methods of use thereof
    Patent number: 8236753
    Abstract: The present invention relates to stabilized RAP variants and methods of use thereof. Conjugates of stabilized RAP variants to therapeutic compounds and stabilized RAP fusion proteins comprising therapeutic polypeptides are also presented.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: August 7, 2012
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Stephen Blacklow, Carl Fisher, Kristine Estrada
  • GENERATION AND CHARACTERIZATION OF ANTI-NOTCH ANTIBODIES FOR THERAPEUTIC AND DIAGNOSTIC USE
    Publication number: 20110286916
    Abstract: The present invention relates to mammalian antibodies, preferably fully human monoclonal antibodies and antigen-binding portions thereof that specifically bind to a cell surface receptor, wherein the receptor protein is a Notch1 receptor protein. Some of the disclosed antibodies bind Notch1 to the exclusion of other members of the Notch receptor family, while other antibodies bind Notch 1 and Notch3. Nucleic acid molecules encoding the Notch antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of Notch1 or Notch3 including aberrant activation of each of these receptors.
    Type: Application
    Filed: November 16, 2009
    Publication date: November 24, 2011
    Inventors: Jose Miguel Aste-Amezaga, Ningyan Zhang, Fubao Wang, Andrew Bett, Anna Demartis, Maurizio Nuzzo, Paolo Monaci, Stephen Blacklow, Jon Aster
  • RAP VARIANTS FOR DRUG DELIVERY
    Publication number: 20110028384
    Abstract: The present invention relates to stabilized RAP variants and methods of use thereof. Conjugates of stabilized RAP variants to therapeutic compounds and stabilized RAP fusion proteins comprising therapeutic polypeptides are also presented.
    Type: Application
    Filed: December 10, 2008
    Publication date: February 3, 2011
    Inventors: Stephen Blacklow, Carl Fisher, Kristine Estrada
  • Functional negative regulatory domain sequences from human NOTCH1 and 2 and isolated LNR domains from human NOTCH1
    Publication number: 20080241150
    Abstract: The present invention relates to a LNR-HD domain of the Notch receptor and methods of use. The method for expression and structural determination of the LNR-HD domain is described.
    Type: Application
    Filed: May 15, 2007
    Publication date: October 2, 2008
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Stephen Blacklow, Didem Vardar-Ulu, Wendy Ryan Gordon, Cheryll Sanchez-Irizarry, Jon C. Aster
  • NOTCH mutations leading to increased receptor signaling
    Publication number: 20070077245
    Abstract: The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increased receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.
    Type: Application
    Filed: August 2, 2005
    Publication date: April 5, 2007
    Applicants: The Brigham and Women's Hospital, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Jon Aster, Stephen Blacklow, A. Look, Adolfo Ferrando, Andrew Weng