Abstract: A decellularised collagen-containing matrix for guided tissue regeneration, wherein the matrix is derived from a natural tissue material and is substantially free of non-fibrous tissue proteins, cellular elements and lipids or lipid residues and wherein the matrix displays the original collagen fibre architecture and molecular ultrastructure of the natural tissue material from which it is derived. The decellularised collagen-containing matrix is useful as an implant for guided tissue regeneration, having a capacity to induce guided regeneration of host tissue.

Abstract: A bone implant derived from natural bone tissue material, wherein the bone implant is substantially free of non-fibrous tissue proteins, cells and cellular elements and lipids or lipid residues and comprises collagen displaying original collagen fibre architecture and molecular ultrastructure of the natural bone tissue material from which it is derived.

Abstract: A vascular implant derived from natural vascular tissue material, wherein the vascular implant is substantially free of non-fibrous tissue proteins, cells and cellular elements and lipids or lipid residues and comprises collagenous material displaying the original fibre architecture and molecular ultrastructure of the natural vascular tissue material from which it is derived.

Abstract: The invention provides a wound dressing or implant comprising an enzymatic compound or reagent that is effective to reduce the concentration of lactate in an aqueous solution in contact with the dressing. Preferably, the compound is a lactate oxidase enzyme that converts lactate present in wound fluid as a consequence of wound hypoxia to pyruvate and hydrogen peroxide.

Abstract: The invention provides the use of alpha-1-antitrypsin for the preparation of a composition for the treatment of a chronic wound, such as a pressure sore or a venous ulcer. The composition is preferably a wound dressing composition, such as an ointment for topical application.

Abstract: A multicellular in vitro assay which models the combined stages of angiogenesis is disclosed. The assay permits the evaluation of drug candidates for their potential utility in treating pathological conditions such as chronic dermal ulcers, tumors, diabetic retinopathy, psoriasis and inflammation.

Abstract: A multicellular in vitro assay which models the combined stages of angiogenesis is disclosed. The assay permits the evaluation of drug candidates for their potential utility in treating pathological conditions such as chronic dermal ulcers, tumors, diabetic retinopathy, psoriasis and inflammation.

Abstract: A multicellular in vitro assay for modeling the combined stages of angiogenesis namely the proliferation, migration and differentiation stages of cell development, wherein the assay comprises providing a dual culture of endothelial cells together with another cell-type exhibiting interaction therewith to display the combined stages of angiogenesis in vitro.

Abstract: The present invention provides the use of N-acetyl cysteine and its pharmaceutically acceptable salts and derivatives, for the preparation of a composition for treatment or prophylaxis of chronic ulcers. In particular, the treatment of venous ulcers, diabetic ulcers and decubitis ulcers.