Patents by Inventor Stephen Brocchini
Stephen Brocchini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9650331Abstract: The invention provides compound of the general formula: in which each X independently represents a polymer chain; n represents an integer greater than 1; Q represents a linker; Y represents an amide group; and Z represents either —CH.(CH2L)2 or —C(CH2L)(?CH2), in which each L independently represents a leaving group. The compounds are useful reagents for the conjugation of polymers to proteins, the resulting conjugates being novel and also forming part of the invention.Type: GrantFiled: June 17, 2013Date of Patent: May 16, 2017Assignee: POLYTHERICS LIMITEDInventors: Antony Godwin, Stephen Brocchini
-
Publication number: 20160145329Abstract: A solid, compressed pharmaceutical composition comprises i) a peptide active pharmaceutical ingredient, ii) a polysaccharide excipient and/or an albumin, and iii) an oligosaccharide excipient. The polysaccharide excipient may be hyaluronic acid, or the potassium salt thereof, and the oligosaccharide excipient may be trehalose.Type: ApplicationFiled: November 16, 2015Publication date: May 26, 2016Inventors: Peng T. KHAW, Stephen BROCCHINI, Ashkan KHALILI
-
Patent number: 9186414Abstract: A solid, compressed pharmaceutical composition comprises i) a peptide active pharmaceutical ingredient, ii) a polysaccharide excipient and/or an albumin, and iii) an oligosaccharide excipient. The polysaccharide excipient may be hyaluronic acid, or the potassium salt thereof, and the oligosaccharide excipient may be trehalose.Type: GrantFiled: October 7, 2011Date of Patent: November 17, 2015Assignee: UCL Business PLCInventors: Peng T. Khaw, Stephen Brocchini, Ashkan Khalili
-
Publication number: 20130338231Abstract: The invention provides compound of the general formula: in which each X independently represents a polymer chain; n represents an integer greater than 1; Q represents a linker; Y represents an amide group; and Z represents either —CH.(CH2L)2 or —C(CH2L)(?CH2), in which each L independently represents a leaving group. The compounds are useful reagents for the conjugation of polymers to proteins, the resulting conjugates being novel and also forming part of the invention.Type: ApplicationFiled: June 17, 2013Publication date: December 19, 2013Inventors: Antony GODWIN, Stephen Brocchini
-
Publication number: 20130266630Abstract: A solid, compressed pharmaceutical composition comprises i) a peptide active pharmaceutical ingredient, ii) a polysaccharide excipient and/or an albumin, and iii) an oligosaccharide excipient. The polysaccharide excipient may be hyaluronic acid, or the potassium salt thereof, and the oligosaccharide excipient may be trehalose.Type: ApplicationFiled: October 7, 2011Publication date: October 10, 2013Applicant: UCL BUSINESS PLCInventors: Peng T. Khaw, Stephen Brocchini, Ashkan Khalili
-
Publication number: 20100278896Abstract: A solid, implantable dosage form comprising a therapeutically active agent in solid form, optionally with one or more pharmaceutically acceptable excipients, wherein the one or more excipients, when present, do not lead to a significant delay or prolongation of the release of active agent, as compared to an equivalent dosage form containing no excipients when tested in vitro.Type: ApplicationFiled: November 17, 2008Publication date: November 4, 2010Applicant: UCL BUSINESS PLCInventors: Peng T. Khaw, Stephen Brocchini
-
Publication number: 20100239517Abstract: The invention provides a novel process for conjugating a polymer, especially PEG, to a protein or peptide, which comprises reacting a polymeric conjugation reagent with a protein or peptide containing a polyhistidine tag under conditions such that conjugation occurs via said polyhistidine tag. The resulting conjugates are novel.Type: ApplicationFiled: October 8, 2008Publication date: September 23, 2010Inventors: Stephen Brocchini, Penny Bryant, Yuehua Cong, Ji-Won Choi, Antony Godwin, Keith Powell
-
Patent number: 7585929Abstract: The present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substrates.Type: GrantFiled: July 13, 2004Date of Patent: September 8, 2009Assignee: Rutgers, The State University of New JerseyInventors: Ken James, Stephen Brocchini, Varawut Tangpasuthadol, Joachim B. Kohn
-
Publication number: 20090176866Abstract: A complex that comprises a narrow molecular weight distribution polymer that includes units derived from an acrylic acid or a salt thereof, and (i) a substance that has pharmacological activity against a pathogenic organism, or (ii) a substance that has pharmacological activity against a cancer, or (iii) one or more agents selected from antigens and immunogens is useful in treating and/or inducing immunity to the pathogenic organism or the cancer, and for inducing immunity to the antigen or immunogen.Type: ApplicationFiled: January 7, 2005Publication date: July 9, 2009Inventors: Sunil Shaunak, Stephen Brocchini, Antony Godwin, Ji-Won Choi
-
Publication number: 20080227855Abstract: A stable composition of an amorphous component (such as a bioactive) and a carrier polymer is formed by mixing a bridging polymer with the bioactive and the carrier polymer, wherein the bridging polymer is a hydrogen bond donor to both the bioactive and the carrier polymer, thereby forming a composition in which the bioactive and the carrier polymer have less of a tendency to crystallise than if the bridging polymer were not present.Type: ApplicationFiled: February 10, 2006Publication date: September 18, 2008Inventors: Graham Buckton, Stephen Brocchini, John Fletcher, Hisham Al-Obaidi
-
Publication number: 20060210526Abstract: Novel biologically active compounds of the general formula (I) in which one of X and X? represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X? represents a polymer, X-Q-W- together may represent an electron withdrawing group; and in addition, if X represents a polymer, X? and electron withdrawing group W together with the interjacent atoms may form a ring; each of Z1 and Z2 independently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety; or Z1 and Z2 together represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties; A is a C1-5 alkylene or alkenylene chain; and B is a bond or a C1-4 alkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucType: ApplicationFiled: July 12, 2004Publication date: September 21, 2006Inventors: Stephen Brocchini, Antony Godwin, Elisa Pedone, Jin-Won Choi, Sunil Shaunak
-
Patent number: 7101840Abstract: A method of forming a polymeric drug formulation in which a water-soluble drug is blended with a water-insoluble tissue-compatible polymer that is miscible in the solid phase with the drug, and with a poly(alkylene oxide), in a solvent system capable of forming a homogeneous solution of the drug, the tissue-compatible polymer and the poly(alkylene oxide), after which the solution is added to a non-solvent for the drug, the tissue-compatible polymer and the poly(alkylene oxide), so that a microdomain-separated solid co-precipitate of the drug, the tissue-compatible polymer and the poly(alkylene oxide) is formed, wherein the poly(alkylene oxide) is blended in an amount effective to form phase-separated microdomains in said co-precipitate.Type: GrantFiled: June 21, 2002Date of Patent: September 5, 2006Assignee: Rutgers, The State UniversityInventors: Stephen Brocchini, Stephen R. Hanson, Joachim B. Kohn
-
Patent number: 7005454Abstract: Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also disclosed containing a single-phase dispersion of a water-soluble drug and a water-insoluble tissue-compatible polymer matrix, and a second, phase-disrupting polymer that is non-miscible with the tissue-compatible polymer and is present in an amount sufficient to form phase-separated microdomains of the second polymer in the tissue-compatible polymer matrix, so that the release rate of the water-soluble drug from the tissue-compatible polymer matrix is related to the amount of the second polymer. Methods of preparing the polymeric drug formulations are also described, as well as methods for site-specific drug delivery utilizing the polymeric drug formulations.Type: GrantFiled: February 24, 1999Date of Patent: February 28, 2006Assignee: Rutgers, The State UniversityInventors: Stephen Brocchini, Stephen R. Hanson, Joachim B. Kohn
-
Publication number: 20050031575Abstract: Novel block copolymers are described, together with the production therefrom of physiologically soluble polymer therapeutics.Type: ApplicationFiled: December 27, 2002Publication date: February 10, 2005Inventors: Stephen Brocchini, Antony Godwin
-
Publication number: 20040062719Abstract: The present invention provides a particulate substrate suitable for carrying a drug for delivery, comprising a substantially crystalline core and a surface coating, wherein the particulate substrate has a proportion of amorphous character of 2% of greater by weight of particulate substrate, and a process for the production of carrier particles comprising the steps of: a) mixing crystalline particles having an average diameter greater than 10 &mgr;m with at least partially amorphous particles having average diameters less than 10 &mgr;m; b) exposing the mixture to conditions capable of inducing crystallization of the amorphous particles for a predetermined period in order that partial crystallization takes place.Type: ApplicationFiled: October 20, 2003Publication date: April 1, 2004Inventors: Graham Buckton, Dima Al-Hadithi, Stephen Brocchini
-
Publication number: 20030068384Abstract: A method of forming a polymeric drug formulation in which a water-soluble drug is blended with a water-insoluble tissue-compatible polymer that is miscible in the solid phase with the drug, and with a poly(alkylene oxide), in a solvent system capable of forming a homogeneous solution of the drug, the tissue-compatible polymer and the poly(alkylene oxide), after which the solution is added to a non-solvent for the drug, the tissue-compatible polymer and the poly(alkylene oxide), so that a microdomain-separated solid co-precipitate of the drug, the tissue-compatible polymer and the poly(alkylene oxide) is formed, wherein the poly(alkylene oxide) is blended in an amount effective to form phase-separated microdomains in said co-precipitate.Type: ApplicationFiled: June 21, 2002Publication date: April 10, 2003Inventors: Stephen Brocchini, Stephen R. Hanson, Joachim B. Kohn
-
Publication number: 20020019446Abstract: Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also disclosed containing a single-phase dispersion of a water-soluble drug and a water-insoluble tissue-compatible polymer matrix, and a second, phase-disrupting polymer that is non-miscible with the tissue-compatible polymer and is present in an amount sufficient to form phase-separated microdomains of the second polymer in the tissue-compatible polymer matrix, so that the release rate of the water-soluble drug from the tissue-compatible polymer matrix is related to the amount of the second polymer. Methods of preparing the polymeric drug formulations are also described, as well as methods for site-specific drug delivery utilizing the polymeric drug formulations.Type: ApplicationFiled: February 24, 1999Publication date: February 14, 2002Inventors: STEPHEN BROCCHINI, STEPHEN R. HANSON, JOACHIM B. KOHN
-
Patent number: 5877224Abstract: Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also disclosed containing a single-phase dispersion of a water-soluble drug and a water-insoluble tissue-compatible polymer matrix, and a second, phase-disrupting polymer that is non-miscible with the tissue-compatible polymer and is present in an amount sufficient to form phase-separated microdomains of the second polymer in the tissue-compatible polymer matrix, so that the release rate of the water-soluble drug from the tissue-compatible polymer matrix is related to the amount of the second polymer. Methods of preparing the polymeric drug formulations are also described, as well as methods for site-specific drug delivery utilizing the polymeric drug formulations.Type: GrantFiled: July 28, 1995Date of Patent: March 2, 1999Assignee: Rutgers, The State University of New JerseyInventors: Stephen Brocchini, Stephen R. Hanson, Joachim B. Kohn
-
Patent number: RE37795Abstract: A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with a L-tyrosine ester in a water-miscible organic reaction solvent containing a carbodiimide capable of forming a water-soluble urea by-product, thereby forming a diphenol reaction product; and combining the reaction mixture with an amount of water effective to precipitate the diphenol as a water-immiscible organic phase, so that a water-immiscible organic phase is formed containing the diphenol reaction product. New diphenol monomers and polymers polymerized therefrom are also discussed.Type: GrantFiled: July 21, 1999Date of Patent: July 16, 2002Inventors: Joachim B. Kohn, Stephen Brocchini, Arthur L. Schwartz