Abstract: As disclosed herein, ?-arrestin1 and ?-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both ?-arrestin1 and ?-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when ?-arrestin2 is overexpressed, tau levels become elevated. The data indicate that ?-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of ?-arrestin2. Therefore, disclosed herein are ?-arrestin oligomerization inhibitors that can be used to prevent ?-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a ?-arrestin oligomerization inhibitor disclosed herein.

Abstract: In one aspect, an ultrasound transducer system comprises a two-dimensional array of transducer elements, the transducer elements having a first side comprising individual first electrodes in electrical communication with control circuitry of the ultrasound transducer system. A matching layer is coupled to a second side of the transducer elements via an electrically conductive face, wherein the electrically conductive face serves as a common electrical contact for the transducer elements. The matching layer also comprises kerfs extending to a depth less than the electrically conductive face.

Abstract: As disclosed herein, ?-arrestin1 and ?-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both ?-arrestin1 and ?-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when ?-arrestin2 is overexpressed, tau levels become elevated. The data indicate that ?-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of ?-arrestin2. Therefore, disclosed herein are ?-arrestin oligomerization inhibitors that can be used to prevent ?-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a ?-arrestin oligomerization inhibitor disclosed herein.

Abstract: Disclosed herein are compounds, compositions, and methods for selecting targeting ?2AR receptors. The compounds, compositions, and methods may be used in the treatment of obstructive lung diseases.

Abstract: A tailor-welded blank is made of two steels, one steel of Alloy A and one steel of Alloy B. Alloy A comprises 0.10-0.50 wt % C, 0.1-0.5 wt % Si, 2.0-8.0 wt % Mn, 0.0-6.0 wt % Cr, 0.0-2.0 wt % Mo, 0.0-0.15 wt % Ti, and 0.0-0.005 wt % B and wherein Alloy B comprises 0.06-0.12 wt % C, 0.1-0.25 wt % Si, 1.65-2.42 wt % Mn, 0.0-0.70 wt % Cr, 0.08-0.40 wt % Mo, 0.0-0.05 wt % V, and 0.01-0.05 wt % Ti.

Abstract: In one embodiment, an apparatus accesses a memory to obtain information regarding sharing history (as pertains, for example, to a particular user and/or device) and uses that sharing history to display at least one recommended sharing action (from amongst a plurality of available candidate sharing actions) as regards to a particular content item (such as, for example, a particular digital photograph, a video, a presentation, and so forth). This sharing history can comprise previously-selected sharing actions as correlated to content item types including shared-content recipients, corresponding temporal data, shared-content size, corresponding location data, and so forth. By one approach the apparatus itself serves to automatically track user-based content-sharing selections over time, which information is stored as the aforementioned sharing history.

Abstract: A monument mounted airbag system for arresting passenger movement during a sudden acceleration/deceleration event of a moving vehicle includes an airbag assembly including at least one airbag on a first portion of a monument structure, the airbag assembly having a housing at least partially defined by a space between an external member and the monument structure.

Abstract: An apparatus for use in a continuous welding system including a welding head configured to remain stationary relative to translating steel sheets or plates. The apparatus includes a hollow elongate body and a port. The body extends between two closed ends. The port is coupled to a non-oxidizing gas source and in communication with the body. The body defines a plurality of openings. The openings are configured to direct non-oxidizing gas towards the steel sheets or plates to simultaneously shield a weld formed by the welding head from atmosphere and cool the weld.

Abstract: A method and a subscriber identity component for providing a wireless device with access to a network node are disclosed. The subscriber identity component is provisioned with information defining a set of pools relating to pool subscriber identities. The subscriber identity component determines a pool subscriber identity based on a pool among the set of pools. The subscriber identity component checks a connection state relating to whether or not the wireless device is granted access to the network node by use of the pool subscriber identity. Furthermore, when the connection state indicates that the wireless device is granted access to the network node, the subscriber identity component provides the wireless device with access to the network node based on the pool subscriber identity. Furthermore, a corresponding computer program and a computer program carrier are disclosed.

Abstract: An electronic user device 2 is disclosed in which a user interface 20 for an email application is displayed. The user interface 20 includes an email thread 22 and a selectable calendar look-up banner 32. Upon selection of the calendar look-up banner 32 the user device 2 is configured to retrieve electronic calendars respectively associated with the email users identified in the email thread 22. A score is then calculated for a plurality of time slots in the retrieved electronic calendars, and the time slots are displayed according to their score. A user can then make a selection of one of the time slots. A calendar event is then populated with information derived from the email thread 22 and is sent to each of the email addresses in the thread, to be added to their electronic calendars.

Abstract: A tailor-welded blank is made of two steels, one steel of Alloy A and one steel of Alloy B. Alloy A comprises 0.10-0.50 wt % C, 0.1-0.5 wt % Si, 2.0-8.0 wt % Mn, 0.0-6.0 wt % Cr, 0.0-2.0 wt % Mo, 0.0-0.15 wt % Ti, and 0.0-0.005 wt % B and wherein Alloy B comprises 0.06-0.12 wt % C, 0.1-0.25 wt % Si, 1.65-2.42 wt % Mn, 0.0-0.70 wt % Cr, 0.08-0.40 wt % Mo, 0.0-0.05 wt % V, and 0.01-0.05 wt % Ti.

Abstract: A tailor-welded blank is created by forming a blank from a steel of composition A and a steel of composition B and welding said two steels together, heating said welded blank to a temperature above the Ac1 temperature associated with the steel of composition A, transferring said blank to a forming die, and then cooling said blank to a temperature between the martensite start temperature and martensite finish temperature of the steel of composition B and holding said blank at such temperature or at a higher temperature, cooling said blank to room temperature. The tailor-welded blank comprises Alloy A and Alloy B, wherein Alloy A comprises 0.10-0.50 wt % C, 0.1-0.5 wt % Si, 2.0-8.0 wt % Mn, 0-6.0 wt % Cr, 0.0-2 wt % Mo, and 0.0-0.005 wt % B and wherein Alloy B comprises 0.06-0.12 wt % C, 0.1-0.25 wt % Si, 1.65-2.42 wt % Mn, 0.0-0.70 wt % Cr, 0.08-0.40 wt % Mo, 0.0-0.05 wt % V, 0.01-0.

Abstract: A monument mounted airbag system for arresting passenger movement during a sudden acceleration/deceleration event of a moving vehicle includes an airbag assembly including at least one airbag on a first portion of a monument structure, the airbag assembly having a housing at least partially defined by a space between an external member and the monument structure.

Abstract: A method of managing data transfer from a server to a portable electronic device via a network includes, by the portable electronic device, initiating data transfer to the portable electronic device, identifying a network connection type by the portable electronic device to the network; setting, by the portable electronic device, a filter size for data record transmission to the portable electronic device, the filter size set based on the network connection type, and requesting, by the portable electronic device, a quantity of data records from the server. The quantity of data records is a number of data records that is dependent on the filter size set based on the network connection type.

Abstract: In one embodiment, an apparatus is configured to facilitate sharing a particular content item (such as, for example, a particular digital photograph, a video, a presentation, and so forth) with the participants of a scheduled calendar event (such as a face-to-face meeting, a distance meeting, an appointment, and so forth). By one approach the user is presented with an opportunity to assert a non-specific share command that triggers the aforementioned display of one or more recommended sharing actions.

Abstract: In one aspect, an ultrasound transducer system comprises a two-dimensional array of transducer elements, the transducer elements having a first side comprising individual first electrodes in electrical communication with control circuitry of the ultrasound transducer system. A matching layer is coupled to a second side of the transducer elements via an electrically conductive face, wherein the electrically conductive face serves as a common electrical contact for the transducer elements. The matching layer also comprises kerfs extending to a depth less than the electrically conductive face.

Abstract: An electronic user device 2 is disclosed in which a user interface 20 for an email application is displayed. The user interface 20 includes an email thread 22 and a selectable calendar look-up banner 32. Upon selection of the calendar look-up banner 32 the user device 2 is configured to retrieve electronic calendars respectively associated with the email users identified in the email thread 22. A score is then calculated for a plurality of time slots in the retrieved electronic calendars, and the time slots are displayed according to their score. A user can then make a selection of one of the time slots. A calendar event is then populated with information derived from the email thread 22 and is sent to each of the email addresses in the thread, to be added to their electronic calendars.

Abstract: A monument mounted airbag system includes an airbag assembly including at least an airbag mounted directly forward of a passenger, and configured to deploy away from the passenger along an intercepting course with a predetermined path of travel of the passenger. Additionally, the airbag may be configured to substantially conform to a monument disposed in proximity thereto, and may include side support, lower support, and active vents.

Abstract: A method of managing data transfer from a server to a portable electronic device via a network includes, by the portable electronic device, initiating data transfer to the portable electronic device, identifying a network connection type by the portable electronic device to the network; setting, by the portable electronic device, a filter size for data record transmission to the portable electronic device, the filter size set based on the network connection type, and requesting, by the portable electronic device, a quantity of data records from the server. The quantity of data records is a number of data records that is dependent on the filter size set based on the network connection type.

Abstract: An aircraft passenger restraint and protection system including an aircraft seat mounted at an oblique angle to a direction of forward travel, a multi-point seat belt associated with the aircraft seat, and a structural mounted airbag located forward of the aircraft seat.