Patents by Inventor Stephen BURLEIGH

Stephen BURLEIGH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH THROUGHPUT RNA-EDITING SCREENING METHODS
    Publication number: 20240102083
    Abstract: Provided herein is a high throughput screening method for identifying guide RNAs (gRNAs) useful for editing a target RNA, wherein the editing is mediated by an RNA editing entity (e.g., a native human adenosine deaminase enzyme for a human subject).
    Type: Application
    Filed: December 1, 2021
    Publication date: March 28, 2024
    Inventors: Brian Booth, Adrian Briggs, Richard Sullivan, Yiannis Savva, Stephen Burleigh, Lina Bagepalli
  • RNA-Editing Compositions and Methods of Use
    Publication number: 20230399635
    Abstract: Provided herein are engineered latent guide RNAs that bind target RNAs to form a guide-target RNA scaffold and are substrates for RNA editing entities, which chemically modify the base of a nucleotide of the target RNA. Also provided herein are compositions, vectors, and cells comprising the engineered latent guide RNAs disclosed herein and methods of use thereof.
    Type: Application
    Filed: November 10, 2021
    Publication date: December 14, 2023
    Inventors: Yiannis SAVVA, Richard SULLIVAN, Brian BOOTH, Adrian BRIGGS, Debojit BOSE, Susan BYRNE, Stephen BURLEIGH