Patents by Inventor Stephen C. Alley

Stephen C. Alley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20230055475
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: March 18, 2022
    Publication date: February 23, 2023
    Inventors: Stephen C. ALLEY, Scott C. JEFFREY, Django SUSSMAN, Dennis R. BENJAMIN, Brian TOKI, Patrick J. BURKE
  • Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
    Patent number: 11319526
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: May 3, 2022
    Assignee: Seagen Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATES AND THEIR USE IN THE TREATMENT OF CANCER
    Publication number: 20210308208
    Abstract: The invention provides methods and compositions for treating cancer, such as ovarian cancer, peritoneal cancer, and fallopian tube cancer, in a subject, such as by the administration of antibody-drug conjugates that bind to tissue factor (TF). The invention also provides articles of manufacture and compositions comprising said antibody drug-conjugates that bind to TF for use in treating cancer (e.g., ovarian cancer, peritoneal cancer, and fallopian tube cancer).
    Type: Application
    Filed: August 14, 2019
    Publication date: October 7, 2021
    Inventors: Reshma A. RANGWALA, Esther C.W. BREIJ, Sandra VERPLOEGEN, Bart DE GOEIJ, Oyewale O. ABIDOYE, Leonardo V. NICACIO, Stephen C. ALLEY
  • ACID-MEDIATED ASSAY FOR ANALYZING LIGAND-DRUG CONJUGATES
    Publication number: 20200363425
    Abstract: Methods of analyzing a ligand-drug conjugate using acid-mediated cleavage and for implementing the methods are provided herein. Further provided include various application of the methods for analysis and development of a ligand-drug conjugate.
    Type: Application
    Filed: November 20, 2018
    Publication date: November 19, 2020
    Inventors: Stephen C. Alley, Russell Sanderson
  • Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
    Patent number: 10443035
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: October 15, 2019
    Assignee: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20190276796
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: May 16, 2019
    Publication date: September 12, 2019
    Inventors: Stephen C. ALLEY, Scott C. JEFFREY, Django SUSSMAN, Dennis R. BENJAMIN, Brian TOKI, Patrick J. BURKE
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20180155677
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: October 10, 2017
    Publication date: June 7, 2018
    Inventors: Stephen C. ALLEY, Scott C. Jeffrey, Django SUSSMAN, Dennis R. BENJAMIN, Brian TOKI, Patrick J. BURKE
  • Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
    Patent number: 9816069
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: November 14, 2017
    Assignee: SEATTLE GENETICS, INC.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20150337259
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: February 26, 2015
    Publication date: November 26, 2015
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
    Patent number: 8993326
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: March 31, 2015
    Assignee: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20140031536
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: October 1, 2013
    Publication date: January 30, 2014
    Applicant: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
    Patent number: 8574907
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: November 5, 2013
    Assignee: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20120183997
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: February 24, 2012
    Publication date: July 19, 2012
    Applicant: Seattle Genetics, Inc.
    Inventors: STEPHEN C. ALLEY, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
    Patent number: 8163551
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Grant
    Filed: May 1, 2009
    Date of Patent: April 24, 2012
    Assignee: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • PARTIALLY LOADED ANTIBODIES AND METHODS OF THEIR CONJUGATION
    Publication number: 20110097322
    Abstract: A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, such as certain radiometals, chelating agents, and toxins, so as to form a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.
    Type: Application
    Filed: October 29, 2010
    Publication date: April 28, 2011
    Applicant: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Michael Torgov, Michael Sun
  • Partially loaded antibodies and methods of their conjugation
    Patent number: 7837980
    Abstract: A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, such as certain radiometals, chelating agents, and toxins, so as to form a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: November 23, 2010
    Assignee: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Michael Torgov, Michael Sun
  • Antibody drug conjugate metabolites
    Patent number: 7750116
    Abstract: Methods of treating a refractory or drug resistant cancer, cell proliferative disorder and tumor cells are provided. Also provided are antibody drug conjugate metabolites.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: July 6, 2010
    Assignee: Seattle Genetics, Inc.
    Inventors: Svetlana O. Doronina, Stephen C. Alley
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20090317869
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: May 1, 2009
    Publication date: December 24, 2009
    Applicant: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • Partially Loaded Antibodies And Methods Of Their Conjugation
    Publication number: 20090010945
    Abstract: A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, such as certain radiometals, chelating agents, and toxins, so as to form a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.
    Type: Application
    Filed: March 2, 2005
    Publication date: January 8, 2009
    Applicant: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Michael Torgov, Michael Sun