Patents by Inventor Stephen C. Blacklow

Stephen C. Blacklow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOTCH mutations leading to increased receptor signaling
    Patent number: 8716233
    Abstract: The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increase receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: May 6, 2014
    Assignees: The Brigham and Women's Hospital, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Jon C. Aster, Stephen C. Blacklow, A. Thomas Look, Adolfo A. Ferrando, Andrew P. Weng
  • NOTCH mutations leading to increased receptor signaling
    Publication number: 20100087358
    Abstract: The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increase receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.
    Type: Application
    Filed: May 22, 2009
    Publication date: April 8, 2010
    Applicants: The Brigham and Women's Hospital, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Jon C. Aster, Stephen C. Blacklow, A. Thomas Look, Adolfo A. Ferrando, Andrew P. Weng
  • Process and compositions for peptide, protein and peptidomimetic synthesis
    Patent number: 6977150
    Abstract: The present invention is a simplified, highly-purified, processive translation system that does not require the addition of translation factors EF-P, W, W2 or rescue. A new translation process offers new, potentially improved, routes to all peptides, proteins and peptidomimetics currently synthesized by alternative routes.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: December 20, 2005
    Inventors: Anthony C. Forster, Stephen C. Blacklow
  • Process and compositions for peptide, protein and peptidomimetic synthesis
    Publication number: 20040091955
    Abstract: The present invention is a simplified, highly-purified, processive translation system that does not require the addition of translation factors EF-P, W, W2 or rescue. A new translation process offers new, potentially improved, routes to all peptides, proteins and peptidomimetics currently synthesized by alternative routes.
    Type: Application
    Filed: January 25, 2002
    Publication date: May 13, 2004
    Inventors: Anthony C. Forster, Stephen C. Blacklow