Patents by Inventor Stephen C. Cosenza

Stephen C. Cosenza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of Drug-Resistant Proliferative Disorders
    Publication number: 20090306207
    Abstract: ?,?-Unsaturated sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar1, Ar2, X, n, * and R are as defined herein are useful for the treatment of proliferative disorders which are resistant to treatment by ATP-competitive kinase inhibitors.
    Type: Application
    Filed: January 4, 2006
    Publication date: December 10, 2009
    Inventors: M. V. Ramana Reddy, E. Premkumar Reddy, Stephen C. Cosenza, Stacey J. Baker
  • Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
    Patent number: 7595347
    Abstract: Pre-treatment with ?,? unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the ?,? unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: September 29, 2009
    Assignee: Temple University—Of The Commonwealth System of Higher Education
    Inventors: Stephen C. Cosenza, M. V. Ramana Reddy, E. Premkumar Reddy
  • Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
    Publication number: 20040214903
    Abstract: Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.
    Type: Application
    Filed: May 21, 2004
    Publication date: October 28, 2004
    Inventors: Stephen C. Cosenza, M.V. Ramana Reddy, E. Premkumar Reddy
  • Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
    Patent number: 6767926
    Abstract: Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: July 27, 2004
    Assignee: Temple University - Of The Commonwealth System of Higher Education
    Inventors: Stephen C. Cosenza, M. V. Ramana Reddy, E. Premkumar Reddy
  • Method for protecting cells and tissues from ionizing radiation toxicity with &agr;, &bgr; unsaturated aryl sulfones
    Patent number: 6667346
    Abstract: Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective &agr;,&bgr; unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increase the dosage of anticancer radiation. In some instances, amelioration of toxicity following inadvertent radiation exposure may be mitigated with administration of &agr;,&bgr; unsaturated arylsulfone.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: December 23, 2003
    Assignees: Temple University - Of The Commonwealth System of Higher Education, Onconova Therapeutics, Inc.
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy, Stephen C. Cosenza, Lawrence Helson
  • (E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof
    Patent number: 6656973
    Abstract: Provided are the compound (E)-4-carboxystyryl-4-chlorobenzyl sulfone, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: December 2, 2003
    Assignee: Temple University - Of the Commonwealth System of Higher Education
    Inventors: Stephen C. Cosenza, M. V. Ramana Reddy, E. Premkumar Reddy
  • (E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof
    Publication number: 20030149109
    Abstract: Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.
    Type: Application
    Filed: November 27, 2002
    Publication date: August 7, 2003
    Inventors: Stephen C. Cosenza, M. V. Ramana Reddy, E. Premkumar Reddy
  • Method for protecting cells and tissues from ionizing radiation toxicity with alpha, beta unsaturated aryl sulfones
    Publication number: 20030060505
    Abstract: Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective &agr;,&bgr; unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increase the dosage of anticancer radiation. In some instances, amelioration of toxicity following inadvertent radiation exposure may be mitigated with administration of &agr;,&bgr; unsaturated arylsulfone.
    Type: Application
    Filed: February 28, 2002
    Publication date: March 27, 2003
    Inventors: E. Premkumar Reddy, M.V. Ramana Reddy, Stephen C. Cosenza, Lawrence Helson