Patents by Inventor Stephen C. Harrison

Stephen C. Harrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biochemically stabilized HIV-1 Env trimer vaccine
    Patent number: 11229696
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: January 25, 2022
    Assignees: Beth Israel Deaconess Medical Center, Inc., Children's Medical Center Corporation
    Inventors: Stephen C. Harrison, Bing Chen, Dan Barouch, Joseph P. Nkolola, Michael Scott Seaman
  • BIOCHEMICALLY STABILIZED HIV-1 ENV TRIMER VACCINE
    Publication number: 20200323976
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 15, 2020
    Inventors: Stephen C. HARRISON, Bing CHEN, Dan BAROUCH, Joseph P. NKOLOLA, Michael Scott SEAMAN
  • Biochemically stabilized HIV-1 Env trimer vaccine
    Patent number: 10653770
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: May 19, 2020
    Assignees: Beth Israel Deaconess Medical Center, Inc., Children's Medical Center Corporation
    Inventors: Stephen C. Harrison, Bing Chen, Dan Barouch, Joseph P. Nkolola, Michael Scott Seaman
  • BIOCHEMICALLY STABILIZED HIV-1 ENV TRIMER VACCINE
    Publication number: 20200023056
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Application
    Filed: September 23, 2019
    Publication date: January 23, 2020
    Inventors: Stephen C. HARRISON, Bing CHEN, Dan BAROUCH, Joseph P. NKOLOLA, Michael Scott SEAMAN
  • Biochemically stabilized HIV-1 env trimer vaccine
    Patent number: 10463729
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: November 5, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., Children's Medical Center Corporation
    Inventors: Stephen C. Harrison, Bing Chen, Dan H. Barouch, Joseph P. Nkolola, Michael Scott Seaman
  • BIOCHEMICALLY STABILIZED HIV-1 ENV TRIMER VACCINE
    Publication number: 20190240319
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Application
    Filed: April 16, 2019
    Publication date: August 8, 2019
    Inventors: Stephen C. HARRISON, Bing CHEN, Dan H. BAROUCH, Joseph P. NKOLOLA, Michael Scott SEAMAN
  • Biochemically stabilized HIV-1 Env trimer vaccine
    Patent number: 10307478
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: June 4, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., Children's Medical Center Corporation
    Inventors: Stephen C. Harrison, Bing Chen, Dan H. Barouch, Joseph P. Nkolola, Michael Scott Seaman
  • BROADLY NEUTRALIZING HUMAN ANTIBODY THAT RECOGNIZES THE RECEPTOR-BINDING POCKET OF INFLUENZA HEMAGGLUTININ
    Publication number: 20180230201
    Abstract: The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.
    Type: Application
    Filed: June 20, 2017
    Publication date: August 16, 2018
    Inventors: James Whittle, Stephen C. Harrison, Barton F. Haynes, Hua-Xin Liao, Michael Anthony Moody, Thomas B. Kepler, Aaron G. Schmidt
  • BIOCHEMICALLY STABILIZED HIV-1 ENV TRIMER VACCINE
    Publication number: 20180207259
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Application
    Filed: March 13, 2018
    Publication date: July 26, 2018
    Inventors: Stephen C. HARRISON, Bing CHEN, Dan H. BAROUCH, Joseph P. NKOLOLA, Michael Scott SEAMAN
  • Biochemically stabilized HIV-1 Env trimer vaccine
    Patent number: 9950060
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: April 24, 2018
    Assignees: Beth Israel Deaconess Medical Center, Children's Medical Center Corporation
    Inventors: Stephen C. Harrison, Bing Chen, Dan H. Barouch, Joseph P. Nkoloa, Michael Scott Seaman
  • BIOCHEMICALLY STABILIZED HIV-1 ENV TRIMER VACCINE
    Publication number: 20170290907
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Application
    Filed: May 16, 2017
    Publication date: October 12, 2017
    Inventors: Stephen C. HARRISON, Bing CHEN, Dan H. BAROUCH, Joseph P. NKOLOA, Michael Scott SEAMAN
  • Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin
    Patent number: 9718873
    Abstract: The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: August 1, 2017
    Assignees: Duke University, Children's Medical Center Corporation
    Inventors: James Whittle, Stephen C. Harrison, Barton F. Haynes, Hua-Xin Liao, M. A. Moody, Thomas B. Kepler, Aaron G. Schmidt
  • Biochemically stabilized HIV-1 ENV trimer vaccine
    Patent number: 9707289
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: July 18, 2017
    Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, NATIONAL INSTITUTES OF HEALTH (NIH), THE UNITED STATES OF AMERICA DEPT. OF HEALTH AND HUMAN SERVICES (DHHS).
    Inventors: Stephen C. Harrison, Bing Chen, Dan C. Barouch, Joseph P. Nkolola, Michael Scott Seaman
  • BROADLY NEUTRALIZING HUMAN ANTIBODY THAT RECOGNIZES THE RECEPTOR-BINDING POCKET OF INFLUENZA HEMAGGLUTININ
    Publication number: 20140302043
    Abstract: The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.
    Type: Application
    Filed: February 3, 2014
    Publication date: October 9, 2014
    Applicants: DUKE UNIVERSITY, CHILDREN'S HOSPITAL BOSTON
    Inventors: James Whittle, Stephen C. Harrison, Barton F. Haynes, Hua-Xin Liao, M. Anthomy Moody, Thomas B. Kepler, Aaron G. Schmidt
  • Fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies
    Patent number: 8741310
    Abstract: Isolated, antigenic polypeptides including a prehairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Antibodies that bind to a prehairpin intermediate conformation of gp41 and methods of making antibodies a that bind to prehairpin intermediate conformation of gp41 are also provided. Vaccines against a prehairpin intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, prehairpin intermediate conformation of gp41 are further provided.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: June 3, 2014
    Assignees: Children's Medical Center Corporation, President and Fellows of Harvard College, Howard Hughes Medical Institute
    Inventors: Bing Chen, Gary H. Frey, Stephen C. Harrison
  • Rotavirus antigens
    Patent number: 8685411
    Abstract: The present invention relates to novel recombinant polypeptide antigens that may comprise subunit vaccines against rotavirus infection. Further, the present invention relates to methods for use of said antigens in the diagnosis, treatment and prevention of rotavirus infection.
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: April 1, 2014
    Assignees: Children's Medical Center Corporation, The Board of Trustees of the Leland Stanford Junior University, The United States of America as represented by the National Institutes of Health (NIH), The United States of America as represented by the Dept. of Health and Human Services (DHHS)
    Inventors: Philip R. Dormitzer, Stephen C. Harrison, Harry B. Greenberg, Joshua Yoder
  • Druggable regions in the dengue virus envelope glycoprotein and methods of using the same
    Patent number: 8673552
    Abstract: The present invention relates to novel druggable regions discovered in dengue virus envelope glycoprotein, or dengue virus E protein, which is a class II viral E protein. The present invention further relates to methods of using the druggable regions to screen potential candidate therapeutics for diseases caused by viruses having class II E proteins, e.g. viral fusion inhibitors.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: March 18, 2014
    Assignee: Children's Medical Center Corporation
    Inventors: Yorgo Modis, Stephen C. Harrison
  • Biochemically Stabilized HIV-1 ENV Trimer Vaccine
    Publication number: 20120045472
    Abstract: Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
    Type: Application
    Filed: April 8, 2011
    Publication date: February 23, 2012
    Applicants: Beth Israel Deaconess Medical Center, Children's Medical Center Corporation
    Inventors: Stephen C. Harrison, Bing Chen, Dan C. Barouch, Joseph P. Nkolola, Michael Scott Seaman
  • Fusion-Intermediate State of HIV-1 gP41 Targeted by Broadly Neutralizing Antibodies
    Publication number: 20110086041
    Abstract: Isolated, antigenic polypeptides including a prehairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Antibodies that bind to a prehairpin intermediate conformation of gp41 and methods of making antibodies a that bind to prehairpin intermediate conformation of gp41 are also provided. Vaccines against a prehairpin intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, prehairpin intermediate conformation of gp41 are further provided.
    Type: Application
    Filed: August 27, 2010
    Publication date: April 14, 2011
    Applicant: Children's Medical Center Corporation
    Inventors: Bing Chen, Gary H. Frey, Stephen C. Harrison
  • Novel Druggable Regions in the Dengue Virus Envelope Glycoprotein and Methods of Using the Same
    Publication number: 20100105151
    Abstract: The present invention relates to novel druggable regions discovered in dengue virus envelope glycoprotein, or dengue virus E protein, which is a class II viral E protein. The present invention further relates to methods of using the druggable regions to screen potential candidate therapeutics for diseases caused by viruses having class II E proteins, e.g. viral fusion inhibitors.
    Type: Application
    Filed: April 27, 2009
    Publication date: April 29, 2010
    Applicant: Children's Medical Center Corporation
    Inventors: Yorgo Modis, Stephen C. Harrison