Patents by Inventor Stephen C. Miller
Stephen C. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240082330Abstract: This document relates to methods and materials involved in treating cancer. For example, methods and materials for using one or more oncolytic viruses (e.g., one or more replicating oncolytic viruses) to treat cancer in a mammal (e.g., a human) identified as having a cancer likely to respond to oncolytic virotherapy are provided.Type: ApplicationFiled: November 14, 2023Publication date: March 14, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: Kah-Whye Peng, Stephen James Russell, Mitesh J. Borad, Yumei Zhou, Amber C. Miller
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Patent number: 9814787Abstract: This disclosure relates to luciferin amides of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to detect fatty acid amide hydrolase activities in vitro, in live cells, or in vivo.Type: GrantFiled: June 3, 2016Date of Patent: November 14, 2017Assignee: University of MassachusettsInventor: Stephen C. Miller
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Patent number: 9587266Abstract: Described are mutant luciferases, nucleic acids that encode them, cells and animals expressing them, methods of use thereof, and kits.Type: GrantFiled: February 9, 2012Date of Patent: March 7, 2017Assignee: University of MassachusettsInventors: Stephen C. Miller, David Mofford, Katryn Harwood
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Publication number: 20160279268Abstract: This disclosure relates to luciferin amides of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to detect fatty acid amide hydrolase activities in vitro, in live cells, or in vivo.Type: ApplicationFiled: June 3, 2016Publication date: September 29, 2016Inventor: Stephen C. Miller
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Patent number: 9370588Abstract: This disclosure relates to luciferin amides of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to detect fatty acid amide hydrolase activities in vitro, in live cells, or in vivo.Type: GrantFiled: March 15, 2013Date of Patent: June 21, 2016Assignee: University of MassachusettsInventor: Stephen C. Miller
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Patent number: 9329185Abstract: This disclosure relates to compounds containing a fluorophore covalently bonded to at least one protected sulfonate group of formula (I): in which X and R2-R5 are defined in the specification. This disclosure also relates to use of these compounds as dyes in an imaging methods, as well as intermediates that can be used to prepare these compounds.Type: GrantFiled: March 10, 2014Date of Patent: May 3, 2016Assignee: University of MassachusettsInventors: Stephen C. Miller, Steven M. Pauff, Adam Choi
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Publication number: 20140275526Abstract: This disclosure relates to compounds containing a fluorophore covalently bonded to at least one protected sulfonate group of formula (I): in which X and R2-R5 are defined in the specification. This disclosure also relates to use of these compounds as dyes in an imaging methods, as well as intermediates that can be used to prepare these compounds.Type: ApplicationFiled: March 10, 2014Publication date: September 18, 2014Applicant: University of MassachusettsInventors: Stephen C. Miller, Steven M. Pauff, Adam Choi
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Publication number: 20140201855Abstract: Described are mutant luciferases, nucleic acids that encode them, cells and animals expressing them, methods of use thereof, and kits.Type: ApplicationFiled: February 9, 2012Publication date: July 17, 2014Applicant: UNIVERSITY OF MASSACHUSETTSInventors: Stephen C. Miller, David Mofford, Katryn Harwood
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Publication number: 20140193340Abstract: This disclosure relates to luciferin amides of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to detect fatty acid amide hydrolase activities in vitro, in live cells, or in vivo.Type: ApplicationFiled: March 15, 2013Publication date: July 10, 2014Applicant: University of MassachusettsInventor: Stephen C. Miller
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Patent number: 8753320Abstract: An apparatus for controlling fluid flow to provide long-term access to the vascular system, and methods of making the same, are disclosed. Exemplary embodiments of the present invention describe a wedge or other similarly shaped geometrical feature for fixing an elastic component and controlling an internal stress of the elastic component.Type: GrantFiled: July 5, 2011Date of Patent: June 17, 2014Assignee: Navilyst Medical, Inc.Inventor: Stephen C. Miller
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Patent number: 8679776Abstract: Novel, activatable dyes, such as photoactivatable dyes, e.g., oxazine dyes, are described. Some of the dyes are targeting dyes that can, e.g., target biomolecules, such as polypeptides, proteins, or nucleic acids. Upon activation, such as by irradiation, the novel dyes rapidly turn on their fluorescence and emit light, such as near-IR light with spatial and temporal precision.Type: GrantFiled: September 12, 2008Date of Patent: March 25, 2014Assignee: University of MassachusettsInventor: Stephen C. Miller
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Patent number: 8523821Abstract: A device for transferring fluids between an internal structure in a living body and an exterior thereof comprises a housing including a pressure activated lumen extending to a distal end opening to a power injection lumen that extends to a distal port configured for connection to a fluid conduit extending to a target structure within the body and a pressure activated valve extending across the pressure activated lumen and controlling fluid flow therethrough, in combination with a proximal port coupled to the housing for movement between a first position in which a proximal end of the power injection lumen opens to the proximal port and a second position in which a proximal end of the pressure activated lumen opens to the proximal port.Type: GrantFiled: November 23, 2011Date of Patent: September 3, 2013Assignee: Navilyst Medical, IncInventor: Stephen C Miller
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Publication number: 20120276564Abstract: Novel luciferins, methods of making luciferins, and uses of the same are disclosed.Type: ApplicationFiled: July 9, 2012Publication date: November 1, 2012Applicant: UNIVERSITY OF MASSACHUSETTSInventor: Stephen C. Miller
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Patent number: 8216550Abstract: Novel luciferins, methods of making luciferins, and uses of the same are disclosed.Type: GrantFiled: February 14, 2011Date of Patent: July 10, 2012Assignee: University of MassachusettsInventor: Stephen C. Miller
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Publication number: 20120136301Abstract: A device for transferring fluids between an internal structure in a living body and an exterior thereof comprises a housing including a pressure activated lumen extending to a distal end opening to a power injection lumen that extends to a distal port configured for connection to a fluid conduit extending to a target structure within the body and a pressure activated valve extending across the pressure activated lumen and controlling fluid flow therethrough, in combination with a proximal port coupled to the housing for movement between a first position in which a proximal end of the power injection lumen opens to the proximal port and a second position in which a proximal end of the pressure activated lumen opens to the proximal port.Type: ApplicationFiled: November 23, 2011Publication date: May 31, 2012Applicant: Navilyst Medical, Inc.Inventor: Stephen C. Miller
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Patent number: 8153393Abstract: Spirolactam targeting compounds, related compounds, uses of such compounds, and methods of making such compounds are disclosed.Type: GrantFiled: February 29, 2008Date of Patent: April 10, 2012Assignee: University of MassachusettsInventors: Stephen C. Miller, Anjan K. Bhunia
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Patent number: 8083721Abstract: A device for transferring fluids between an internal structure in a living body and an exterior thereof, comprises a housing including a pressure activated lumen extending to a distal end opening to a power injection lumen that extends to a distal port configured for connection to a fluid conduit extending to a target structure within the body and a pressure activated valve extending across the pressure activated lumen and controlling fluid flow therethrough, the pressure activated valve opening to permit fluid flow therethrough into the power injection lumen when a fluid pressure differential thereacross is at least a first predetermined threshold level and remaining sealed when the fluid pressure differential thereacross is less than the first threshold level in combination with a proximal port coupled to the housing for movement between a first position in which a proximal end of the power injection lumen opens to the proximal port and a second position in which a proximal end of the pressure activated lumType: GrantFiled: January 29, 2009Date of Patent: December 27, 2011Assignee: Navilyst Medical, Inc.Inventor: Stephen C. Miller
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Publication number: 20110264054Abstract: An apparatus for controlling fluid flow to provide long-term access to the vascular system, and methods of making the same, are disclosed. Exemplary embodiments of the present invention describe a wedge or other similarly shaped geometrical feature for fixing an elastic component and controlling an internal stress of the elastic component.Type: ApplicationFiled: July 5, 2011Publication date: October 27, 2011Applicant: Navilyst Medical, Inc.Inventor: Stephen C. Miller
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Patent number: 8007468Abstract: An apparatus for controlling fluid flow through medical devices, specifically for sealing devices which remain in place in the body to provide long term access to the vascular system. Exemplary embodiments of the present invention describe a wedge or other similarly shaped geometrical feature for fixing an elastic component and controlling an internal stress of the elastic component.Type: GrantFiled: July 13, 2009Date of Patent: August 30, 2011Assignee: Navilyst Medical, Inc.Inventor: Stephen C. Miller
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Patent number: D1022197Type: GrantFiled: November 19, 2020Date of Patent: April 9, 2024Assignee: Auris Health, Inc.Inventors: Juan B. Bajana Merizalde, Thomas G. T. Brisebras, Fabien Y. Schmitt, Matthew C. Miller, Stephen M. Christopher, Shawn C. Snyder, Evan N. Stambler, Clinton W. Denlinger, Samuel J. Malanowski