Patents by Inventor Stephen Charles Trowell

Stephen Charles Trowell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190345535
    Abstract: The present invention relates to sensors and methods for detecting bacterial proteases in a sample. In particular, the present invention relates to sensors and methods for detecting Pseudomonas spp. protease activity in a sample. The sensors and methods may be used to detect or predict spoilage of a dairy product. The invention also relates to methods for preparing samples for protease assays.
    Type: Application
    Filed: November 13, 2017
    Publication date: November 14, 2019
    Inventors: Helen Dacres, Stephen Charles Trowell
  • Patent number: 10473665
    Abstract: The present invention relates to methods and systems for detecting one or more analytes in a sample and/or for classifying a sample. In particular, the present invention relates to methods and systems which can be used to detect the analytes in real time and which rely on flowing through a microfluidic device one or more types of sensor molecule each comprising a domain that binds one or more analytes, a chemiluminescent donor domain and an acceptor domain, wherein the separation and relative orientation of the chemiluminescent donor domain and the acceptor domain, in the presence and/or the absence of analyte, is within +50% of the Forster distance.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: November 12, 2019
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Stephen Charles Trowell, Helen Dacres, Nam Cao Hoai Le, Murat Gel, Yonggang Zhu, Nan Wu
  • Publication number: 20150094219
    Abstract: The present invention relates to methods and systems for detecting one or more analytes in a sample and/or for classifying a sample. In particular, the present invention relates to methods and systems which can be used to detect the analytes in real time and which rely on flowing through a microfluidic device one or more types of sensor molecule each comprising a domain that binds one or more analytes, a chemiluminescent donor domain and an acceptor domain, wherein the separation and relative orientation of the chemiluminescent donor domain and the acceptor domain, in the presence and/or the absence of analyte, is within +50% of the Forster distance.
    Type: Application
    Filed: April 15, 2013
    Publication date: April 2, 2015
    Inventors: Stephen Charles Trowell, Helen Dacres, Nam Cao Hoai Le, Murat Gel, Yonggang Zhu, Nan Wu
  • Patent number: 8647887
    Abstract: The present invention relates to methods and polypeptides for detecting a compound in a sample. In particular, the present invention relates to the use of a cell-free composition comprising at least one G protein coupled receptor embedded in a lipid Mayer which when expressed in a cell the N-terminus of the G protein coupled receptor, or subunits thereof, is outside the cell and the C-terminus is inside the cell, and which is capable of binding the compound. Optionally, the composition also comprises at least one accessory molecule that directly or indirectly binds an intracellular loop and/or the C-terminus of the G protein coupled receptor. The G protein coupled receptor, and/or accessory molecule when present, in combination comprise a bioluminescent protein and an acceptor molecule, which enables bioluminescent resonance energy transfer (BRET) to be used to detect the compound binding the receptor.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: February 11, 2014
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Stephen Charles Trowell, Irene Mary Horne, Helen Dacres, Virginia Leitch
  • Patent number: 8227572
    Abstract: Nucleotide and amino acid sequences of luciferase peptides that are encoded by genes within the genome of Arachnocampa (Diptera) are disclosed. Specifically provided are functional ATP-dependent luciferases that catalyze luminescence reactions with emission spectra within the blue portion of the spectrum. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and active subsequences of the enzyme peptides, and methods of identifying modulators and substrates of the luciferase peptides. Methods of assays, including multiple reporter assays utilizing at least two ATP-dependent luciferases are provided.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: July 24, 2012
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Virginia Leitch, Mira Maria Dumancic, Stephen Charles Trowell, Helen Dacres
  • Publication number: 20120077210
    Abstract: The present invention relates to methods and polypeptides for detecting a compound in a sample. In particular, the present invention relates to the use of a cell-free composition comprising at least one G protein coupled receptor embedded in a lipid Mayer which when expressed in a cell the N-terminus of the G protein coupled receptor, or subunits thereof, is outside the cell and the C-terminus is inside the cell, and which is capable of binding the compound. Optionally, the composition also comprises at least one accessory molecule that directly or indirectly binds an intracellular loop and/or the C-terminus of the G protein coupled receptor. The G protein coupled receptor, and/or accessory molecule when present, in combination comprise a bioluminescent protein and an acceptor molecule, which enables bioluminescent resonance energy transfer (BRET) to be used to detect the compound binding the receptor.
    Type: Application
    Filed: January 28, 2010
    Publication date: March 29, 2012
    Inventors: Stephen Charles Trowell, Irene Mary Horne, Helen Dacres, Virginia Leitch
  • Publication number: 20110015095
    Abstract: Nucleotide and amino acid sequences of luciferase peptides that are encoded by genes within the genome of Arachnocampa (Diptera) are disclosed. Specifically provided are functional ATP-dependent luciferases that catalyze luminescence reactions with emission spectra within the blue portion of the spectrum. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and active subsequences of the enzyme peptides, and methods of identifying modulators and substrates of the luciferase peptides. Methods of assays, including multiple reporter assays utilizing at least two ATP-dependent luciferases are provided.
    Type: Application
    Filed: August 18, 2006
    Publication date: January 20, 2011
    Inventors: Virginia Leitch, Mira Maria Dumancic, Stephen Charles Trowell, Helen Dacres
  • Patent number: 7029869
    Abstract: The invention relates to any assay for the identification of nematicidal compounds such as anthelmintics for the control of nematodes. The assay comprises: (i) incubating a nematode sample (i.e. a “test nematode sample”) containing a pre-determined amount of nematodes with an ingestable substrate labelled with a readily detectable label, under conditions suitable for nematode feeding, wherein said incubation is conducted in the presence of said candidate nematicidal compound or follows a pre-incubation of said nematode sample with said candidate nematicidal compound, and (ii) determining whether said candidate nematicidal compound affects nematode feeding by detecting an increase or decrease in ingested substrate as compared to that which has been ingested by a control nematode sample which has been incubated without said candidate nematicidal compound.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: April 18, 2006
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Stephen Charles Trowell, Chunyan Liao, Peter David East
  • Publication number: 20040029918
    Abstract: A method for treating a microbial infection or disease in a subject, said method comprising administering to said subject an effective amount of a compound according to the formula (1). Wherein; denotes a single or double bond or an epoxidised bond, and A1 to A13 are independently selected from moieties as depicted in the description. Also claimed are methods for disinfecting surfaces using the above compound, and claims to the above compound.
    Type: Application
    Filed: May 22, 2003
    Publication date: February 12, 2004
    Inventors: Rodney Warren Rickards, Chunjiu Zhao, Stephen Charles Trowell
  • Publication number: 20030186370
    Abstract: Invertebrate 5-HT3 receptors, especially from the nematode Ceanorhabditis elegans, and polynucleotide molecules encoding same are disclosed. The receptors and polynucleotide molecules may be used in assays to identify and/or assess candidate compounds for use as nematicidal, insecticidal and/or other pesticidal use.
    Type: Application
    Filed: November 26, 2002
    Publication date: October 2, 2003
    Inventors: Stephen Charles Trowell, Mira Dumancic, Chunyan Llao, Peter Easr
  • Publication number: 20030012732
    Abstract: The invention relates to any assay for the identification of nematicidal compounds such as anthelmintics for the control of nematodes. The assay comprises: (i) incubating a nematode sample (i.e. a “test nematode sample”) containing a pre-determined amount of nematodes with an ingestable substrate labelled with a readily detectable label, under conditions suitable for nematode feeding, wherein said incubation is conducted in the presence of said candidate nematicidal compound or follows a pre-incubation of said nematode sample with said candidate nematicidal compound, and (ii) determining whether said candidate nematicidal compound affects nematode feeding by detecting an increase or decrease in ingested substrate as compared to that which has been ingested by a control nematode sample which has been incubated without said candidate nematicidal compound.
    Type: Application
    Filed: August 8, 2002
    Publication date: January 16, 2003
    Inventors: Stephen Charles Trowell, Chunyan Liao, Peter David East
  • Patent number: 6441139
    Abstract: The present invention provides an isolated immunoreactive molecule (IRM) capable of binding to a target molecule from at least one species or sub-species of the insect but not to at least one other species or sub-species of insect and a method of identifying one or more insect species or subspecies and kits therefor. The invention is particularly useful for distinguishing between Lepidopterans such as Helicoverpa aemigera and H. punctigera, and H. zea and Heliothis virescens.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: August 27, 2002
    Assignee: Commonwealth Scientific and Industrial Research
    Inventors: Stephen Charles Trowell, Kim Astrid Garsia, Amanda Susan Hill, Gabriele Annerose Lang, John Howard Skerritt
  • Patent number: 5871939
    Abstract: An isolated immunoreactive molecule (IRM) capable of binding to a target molecule from at least one species or sub-species of the insect but not to at least one other species or sub-species of insect and a method of identifying one or more insect species or subspecies and kits therefor. The invention is particularly useful for distinguishing between Lepidopterans such as Helicoverpa armigera and H. punctigera.
    Type: Grant
    Filed: January 25, 1994
    Date of Patent: February 16, 1999
    Assignee: Commonwealth Scientific and Industrial Research Organization
    Inventors: Stephen Charles Trowell, Kim Astrid Garsia, Amanda Susan Hill, Gabriele Annierose Lang, John Howard Skerritt