Abstract: The present disclosure describes a dosing regimen of an IL-10F129S expression construct for treating an inflammatory joint disease (e.g., osteoarthritis) in a subject. Methods are provided for treating an inflammatory joint disease in a subject by injecting a first dose and second dose of a composition comprising an IL-10F129S expression construct into an inflamed joint of the subject according to a dosing regimen wherein the two doses of the expression construct are administered to a subject approximately 150-360 days apart. The present disclosure also provides kits comprising a first and second dose of an IL-10F129S expression construct. The kits may be useful for treating an inflammatory joint disease in a subject.

Abstract: Disclosed herein are intraocular lenses with features that counteract the effects of anterior capsular contraction and methods for implanting such intraocular lenses. In some embodiments, the intraocular lenses can comprise an optic fluid chamber and a haptic having a haptic fluid lumen in fluid communication with the optic fluid chamber. The haptic fluid lumen can comprise a thickened anterior portion such that a thickness of the anterior haptic wall of the haptic is greater than the thickness of the posterior haptic wall. Moreover, the intraocular lenses can comprise one or more support columns disposed within the haptic fluid lumen. The support columns and/or the thickened anterior portion of the haptic can maintain a shape of the haptic fluid lumen in response to forces applied to the haptic as a result of anterior capsular contraction.

Abstract: Disclosed herein are intraocular lenses comprising an optic portion and at least one haptic having a proximal end coupled to the optic portion and a distal end. The haptic comprising a haptic lumen extending through at least part of the haptic. The haptic can comprise one or more haptic isolators disposed within the haptic lumen. The one or more haptic isolators can be configured to counteract or reduce unintended shape changes caused by an external energy directed at the haptic.

Abstract: An IOL system includes a capsular ring having a concave exterior surface extending around its circumference that is configured, upon insertion into a capsular bag of a patient's eye, to engage an equatorial region of the capsular bag. The concave exterior surface extends between an anterior surface and a posterior surface of the capsular ring. A first one or more flaps are arranged on the anterior surface such that at least a portion of each of the first one or more flaps, upon insertion into the capsular bag of a patient's eye, engages an anterior portion of the capsular bag. Similarly, a second one or more flaps are arranged on the posterior surface such that at least a portion of each of the second one or more flaps, upon insertion into a capsular bag of a patient's eye, engages a posterior portion of the capsular bag.

Abstract: The present invention encompasses improved morphian compositions and methods of use of the improved compositions for modulating neuropathic pain, opioid-induced glial activation, or a combination thereof beyond what is currently known in the art. The methods involve administering the compound of Formula I to a subject.

Abstract: The present invention encompasses improved morphian compositions and methods of use of the improved compositions for modulating neuropathic pain, opioid-induced glial activation, or a combination thereof beyond what is currently known in the art. The methods involve administering the compound of Formula I to a subject.

Abstract: A non-woven fabric comprising bicomponent fibers. The non-woven fabric has a core containing polylactic acid (PLA-1), coated with an envelope containing polylactic acid (PLA-2). The fibers are characterised in that PLA-1 is a copolymer of lactic acid monomers L1 and lactic acid monomers D1, and PLA-2 is a copolymer of lactic acid monomers L2 and lactic acid D2, whose D2 monomers rate is greater than the monomers rate D1 of PLA-1. The core further contains a polymeric plasticizer. The non-woven fabric may be used for making coffee filters and/or capsules via a thermoforming process for use in a percolating apparatus.

Abstract: Apparatus and methods for optical detection of contamination are disclosed. In one arrangement, an excitation source (24) directs excitation radiation (26) into or onto an entity (22) to be tested. A first optical concentrator (28) is configured to receive radiation emitted due to fluorescence indicative of contamination in or on the entity (22). The emitted radiation (30) is received via an input surface (32). Concentrated radiation is output via an output surface (34). The first optical concentrator (28) comprises a first wavelength converting element that converts the received radiation to longer wavelength radiation prior to the output of the radiation via the output surface (34). A detection system (38) detects radiation output from the output surface of the first optical concentrator.

Abstract: The present invention encompasses improved morphian compositions and methods of use of the improved compositions for modulating neuropathic pain, opioid-induced glial activation, or a combination thereof beyond what is currently known in the art. The methods involve administering the compound of Formula I to a subject.

Abstract: An IOL system includes a capsular ring having a concave exterior surface extending around its circumference that is configured, upon insertion into a capsular bag of a patient's eye, to engage an equatorial region of the capsular bag. The concave exterior surface extends between an anterior surface and a posterior surface of the capsular ring. A first one or more flaps are arranged on the anterior surface such that at least a portion of each of the first one or more flaps, upon insertion into the capsular bag of a patient's eye, engages an anterior portion of the capsular bag. Similarly, a second one or more flaps are arranged on the posterior surface such that at least a portion of each of the second one or more flaps, upon insertion into a capsular bag of a patient's eye, engages a posterior portion of the capsular bag.

Abstract: An IOL system includes a capsular ring having a concave exterior surface extending around its circumference that is configured, upon insertion into a capsular bag of a patient's eye, to engage an equatorial region of the capsular bag. The concave exterior surface extends between an anterior surface and a posterior surface of the capsular ring. A first one or more flaps are arranged on the anterior surface such that at least a portion of each of the first one or more flaps, upon insertion into the capsular bag of a patient's eye, engages an anterior portion of the capsular bag. Similarly, a second one or more flaps are arranged on the posterior surface such that at least a portion of each of the second one or more flaps, upon insertion into a capsular bag of a patient's eye, engages a posterior portion of the capsular bag.

Abstract: A receiver assembly (100) and data communications method are disclosed. In one arrangement, a receiver assembly (100) comprises a concentration stage (14). The concentration stage (14) receives radiation via an input surface (120) and outputs concentrated radiation via an output surface (122). The concentration stage comprises a wavelength converting member (6) that converts radiation to longer wavelength radiation. An optical element (102) is provided which is such that if a plane wave of radiation is incident on the optical element a spatial distribution of radiation derived from the plane wave on the input surface of the concentration stage varies as a function of a direction of incidence of the plane wave relative to the optical element. A plurality of detectors (42) are provided, each detecting radiation output from a different portion of the output surface of the concentration stage.

Abstract: A receiver assembly (1) has a radiation guide (4) having an elongate form. The length is at least five times longer than all dimensions of the radiation guide perpendicular to the longitudinal axis (3). The guide receives radiation via an outer lateral surface (8), converts the radiation to longer wavelength radiation, and guides the converted radiation to a longitudinal end surface (2). A receiver unit (5) receives radiation output from the longitudinal end surface.

Abstract: A non-woven fabric comprising bicomponent fibers. The non-woven fabric has a core containing polylactic acid (PLA-1), coated with an envelope containing polylactic acid (PLA-2). The fibers are characterised in that PLA-1 is a copolymer of lactic acid monomers L1 and lactic acid monomers D1, and PLA-2 is a copolymer of lactic acid monomers L2 and lactic acid D2, whose D2 monomers rate is greater than the monomers rate D1 of PLA-1. The core further contains a polymeric plasticizer. The non-woven fabric may be used for making coffee filters and/or capsules via a thermoforming process for use in a percolating apparatus.

Abstract: An educational apparatus has a controller linked with student devices, and a teacher device. Each student device is in the form of a desk with a board, a touch sensor array in the board, a display physically separate from the array, and permanent indicia. The apparatus recognises touch by a student on the board, and this is mapped to content of an overlay sheet of paper placed on the board. Moreover, multiple devices may be juxtaposed, and events may be recognised based on all of the group of devices together. An example is a paper sheet covering four devices together and having a map printed on it, in which the software recognised a particular location of touch on a particular device as being a specific region on the map.

Abstract: An IOL system includes a capsular ring having a concave exterior surface extending around its circumference that is configured, upon insertion into a capsular bag of a patient's eye, to engage an equatorial region of the capsular bag. The concave exterior surface extends between an anterior surface and a posterior surface of the capsular ring. A first one or more flaps are arranged on the anterior surface such that at least a portion of each of the first one or more flaps, upon insertion into the capsular bag of a patient's eye, engages an anterior portion of the capsular bag. Similarly, a second one or more flaps are arranged on the posterior surface such that at least a portion of each of the second one or more flaps, upon insertion into a capsular bag of a patient's eye, engages a posterior portion of the capsular bag.