Abstract: Provided are methods and compositions comprising anti-CD6 antibodies, such as itolizumab, which selectively target CD6high T cells, for example, to reduce levels of cell surface CD6 on such cells, decrease the overall levels and pathogenic activity of CD6high T cells or the ratio of CD6high:CD6low T cells in a subject or ex vivo, decrease the overall levels and pathogenic activity of Teff cells or the ratio of Teff:Treg cells in a subject or ex vivo, and/or increase generation of Treg cells in a subject or ex vivo, and thereby modulate a pathogenic immune response in the subject, among other aspects.

Abstract: A rotation apparatus for a boom of a mining vehicle includes a rotation device having an axial central axis. The rotation device has a housing and an inner manifold having a tube-like structure with a space within, wherein the inner manifold is arranged concentrically inside the housing. The housing is arranged to rotate around the axial central axis and the housing includes a housing channel. The inner manifold has a fluid channel having a fluid inlet for receiving fluid from the boom, and the fluid channel is connected to the housing channel for forming a fluid conduit through the rotation device.

Abstract: The present disclosure provides methods of treating inflammatory or autoimmune diseases (e.g., lupus nephritis) using CD6-ALCAM pathway inhibitors such as EQ001 and to methods and diagnostic tests for identifying subjects likely to respond to such inhibitors. In particular, the present disclosure provides diagnostic and therapeutic uses related to elevated levels of soluble ALCAM and/or CD6 protein and protein fragments in urine and other biological samples that are indicative of sensitivity to inhibitors of the CD6-ALCAM pathway (e.g., EQ001).

Abstract: The disclosure provides compositions and methods related to treating, ameliorating, and preventing asthma, and in particular steroid resistant or refractory severe asthma, with an anti-CD6 antibody, itolizumab, or an antigen binding portion thereof, alone or in combination with other agents useful in treating asthma.

Abstract: A feed beam, a rock drilling unit and to a method of manufacturing a feed beam is provided. The feed beam includes a basic profile element, which has two or more superimposed material layers. At least one of the material layers may be made of a composite material.

Abstract: A feed beam, a rock drilling unit and to a method of manufacturing a feed beam is provided. The feed beam includes a basic profile element, which has two or more superimposed material layers. At least one of the material layers may be made of a composite material.

Abstract: Methods and systems for providing data, generated by a computer application, to a database.

Abstract: A method of monitoring, and a system to perform the method of monitoring, a mobile network, the method including receiving a data stream from one or more monitoring points of the mobile network and generating a detail record of an information transaction in the mobile network, storing the generated detail record in a data record storage unit immediately upon completion of the information transaction, and notifying a user that the detail record is available to be viewed.

Abstract: A method of monitoring, and a system to perform the method of monitoring, a mobile network, the method including generating detail records of information transactions in the mobile network; correlating dissimilar detail records from different ones of the monitoring points according to one or more common attributes of the dissimilar detail records, and aggregating at least a portion of the correlated detail records into a single group; and presenting the aggregated detail records in a high level presentation in a graphical user interface.

Abstract: A method of filtering transaction data from interfaces is provided in a mobile telephony network. In the method, the call data from related frames from the network is filtered to check for network status and provide notification of specified events corresponding to the network. System and computer program products which can execute a method of the invention are also provided.

Abstract: Systems and methods are provided for the management and analysis of detail records in a mobile telephony network, including the ability to store remotely and retrieve detail records given a specific call or a data session for signaling analysis in such networks. Computer program products which can execute such methods are also provided.