Abstract: The present invention relates to sulfonylureas and sulfonylthioureas comprising a monocyclic imidazolyl group of formula (I): wherein Q is selected from O or S, R1 is an imidazolyl group, wherein the imidazolyl group is unsubstituted or substituted with one or more monovalent substituents, and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: The technology detects undesirable data packets. Data packets are received from multiple sources at one or more packet switches in a data communications network. The one or more packet switches route the data packets to one or more intended destination computing nodes and also transmit a copy of all the data packets received in the data communications network to a network capture device. The network capture device processes the data packets, detects financial data packets, and transmits the detected financial data packets for analysis by a risk exposure computer system that performs automatic financial risk analysis based on the detected financial data packets.

Abstract: The present invention relates to the classification of cancers, in particular prostate cancers, using samples from patients. In particular, the invention provides methods for identifying potentially aggressive prostate cancers to determine which cancers are or will become aggressive (and hence require treatment) and which will remain indolent (and will therefore not require treatment). The present invention is therefore useful to identify patients with a poor prognosis. The specific population of cancer identified by the present invention is referred to herein as DESNT cancer. The invention also provides biomarker panels useful in the diagnosis and prognosis of cancer.

Abstract: State of the art approaches being used for material replenishment planning have the disadvantage that they fall short in addressing the realities of evolving demand mixes and product utilization. The technologies leverage inflexible statistical models which are tightly coupled to specific industries, business processes, and deeper assumptions and therefore the model and any optimization produce results where the quality of results is heavily curtailed as real business processes deviate from the model assumptions and unforeseen scenarios arise the business and the broader ecosystem evolve. The method and system disclosed in the embodiments herein facilitate generating simulation of various material replenishment scenarios based on a user input. The method and system further generates one or more recommendations for material replenishment, based on an optimization process carried out.

Abstract: The technology detects undesirable data packets. Data packets are received from multiple sources at one or more packet switches in a data communications network. The one or more packet switches route the data packets to one or more intended destination computing nodes and also transmit a copy of all the data packets received in the data communications network to a network capture device. The network capture device processes the data packets, detects financial data packets, and transmits the detected financial data packets for analysis by a risk exposure computer system that performs automatic financial risk analysis based on the detected financial data packets.

Abstract: The present invention relates to the classification of cancers, in particular prostate cancers, using samples from patients. In particular, the invention provides methods for identifying potentially aggressive prostate cancers to determine which cancers are or will become aggressive (and hence require treatment) and which will remain indolent (and will therefore not require treatment). The present invention is therefore useful to identify patients with a poor prognosis. The specific population of cancer identified by the present invention is referred to herein as DESNT cancer. The invention also provides biomarker panels useful in the diagnosis and prognosis of cancer.

Abstract: Cryptographic techniques are provided for generating, distributing, validation, and processing secure commands on different devices and/or peripherals. A control device generates and encrypts a key corresponding to a secure command using a private key of control device to produce a key envelope. Control device further encrypts the key envelope with a recipient's public key producing a recipient envelope. The recipient envelope is delivered to a recipient's device. The recipient's device decrypts the recipient envelope with a private key of the recipient's device producing the key envelope. The key envelope is delivered back to the control device. The control device decrypts the key envelope producing the key, validates the key, and processes a secure command on behalf of a secure resource or delivers the secure command to the secure resource for processing. In an embodiment, control device maintains audit records/audit trail, which is maintained on the control device.

Abstract: The present invention relates to biomarkers and diagnostic profiles based on the expression status of particular genes for use in the diagnosis of prostate cancer, in particular the early detection of prostate cancer and prediction of disease progression and Gleason ?4 cancer. The present invention also provides methods of diagnosis and treatment of prostate cancer, and kits for the early detection of prostate cancer based on the expression status of the biomarkers in biological samples, in particular urine samples.

Abstract: The technology detects undesirable data packets. Data packets are received from multiple sources at one or more packet switches in a data communications network. The one or more packet switches route the data packets to one or more intended destination computing nodes and also transmit a copy of all the data packets received in the data communications network to a network capture device. The network capture device processes the data packets, detects financial data packets, and transmits the detected financial data packets for analysis by a risk exposure computer system that performs automatic financial risk analysis based on the detected financial data packets.

Abstract: Systems and methods are provided for creating and/or modifying memory configuration settings (e.g., such as memory timing and memory drive voltage) for use at selected and/or varying memory temperature/s. The disclosed systems and methods may be implemented to create a relationship between optimized memory configuration settings for different memory temperatures during burn-in testing and/or on an ad-hoc basis.

Abstract: The technology detects undesirable data packets. Data packets are received from multiple sources at one or more packet switches in a data communications network. The one or more packet switches route the data packets to one or more intended destination computing nodes and also transmit a copy of all the data packets received in the data communications network to a network capture device. The network capture device processes the data packets, detects financial data packets, and transmits the detected financial data packets for analysis by a risk exposure computer system that performs automatic financial risk analysis based on the detected financial data packets.

Abstract: The present invention relates to the classification of cancers, in particular prostate cancers, using samples from patients. In particular, the invention provides methods for identifying potentially aggressive prostate cancers to determine which cancers are or will become aggressive (and hence require treatment) and which will remain indolent (and will therefore not require treatment). The present invention is therefore useful to identify patients with a poor prognosis. The specific population of cancer identified by the present invention is referred to herein as DESNT cancer. The invention also provides biomarker panels useful in the diagnosis and prognosis of cancer.

Abstract: A transaction is centrally controlled over multiple communication channels as a sequence of discrete processing units some of which are distributed. In an embodiment, the transaction's processing progression can be shared of the communication channels and paused on one communication channel and resumed on a different communication channel.

Abstract: Systems and methods are provided for creating and/or modifying memory configuration settings (e.g., such as memory timing and memory drive voltage) for use at selected and/or varying memory temperature/s. The disclosed systems and methods may be implemented to create a relationship between optimized memory configuration settings for different memory temperatures during burn-in testing and/or on an ad-hoc basis.

Abstract: A user initiates a voice request to perform an operation with an external service and provides a voice credential for the operation. A determination is made as to whether the user has used a separate device from that which is associated with the voice request to log into the external service within a preceding amount of time before the voice request and/or within a succeeding amount of time following the voice request. If the user has such a login with the external service, the voice operation is processed on behalf of the user with the external service using the voice credential; otherwise the voice request is ignored.

Abstract: The technology detects undesirable data packets. Data packets are received from multiple sources at one or more packet switches in a data communications network. The one or more packet switches route the data packets to one or more intended destination computing nodes and also transmit a copy of all the data packets received in the data communications network to a network capture device. The network capture device processes the data packets, detects financial data packets, and transmits the detected financial data packets for analysis by a risk exposure computer system that performs automatic financial risk analysis based on the detected financial data packets.

Abstract: A system and method for collaborative product configuration optimization model. A plurality of product families and corresponding one or more product sub-families, a plurality of options families associated with each of the sub-product families is obtained. The option family includes one or more option variants. A first product family from the plurality of product families is selected and the one or more option variants of the first product family is associated with a reference value and is selected based on availability of the one or more option variants. A feasible configuration set for the selected first product family is generated by iteratively performing, for each of a unit of demand, a multi-constrained longest path search traversing across the plurality of option families in an non-increasing order of an average of the reference value of the plurality of the option families and a list of configurations is optimized based on the generated feasible configuration.

Abstract: Various embodiments herein each include at least one of systems, methods, and software for check image data inference processing. Another example method embodiment includes inferring a check amount of a check image included in an account group of check images stored in a memory device. Where the check amount is missing in check data associated with the check image or was poorly read by an optical character recognition process, the method includes inferring of the check amount based at least in part on one or more check amounts of check data associated with other check images of the account group. Once inferred, the method includes updating the check amount of the check data associated with the respective check image with the inferred check amount of the check image. Some embodiments also or alternatively include inferring a check date.

Abstract: The technology detects undesirable data packets. Data packets are received from multiple sources at one or more packet switches in a data communications network. The one or more packet switches route the data packets to one or more intended destination computing nodes and also transmit a copy of all the data packets received in the data communications network to a network capture device. The network capture device processes the data packets, detects financial data packets, and transmits the detected financial data packets for analysis by a risk exposure computer system that performs automatic financial risk analysis based on the detected financial data packets.

Abstract: A PIM (passive intermodulation) diagnosis is generated for one or more wireless networks which have equipment deployed at a plurality of cell sites. Data is received representing PIM detection results from PIM detection devices at the cell sites, the detected PIM including PIM caused by passive intermodulation between carriers of the one or more wireless networks. The data representing respective PIM detection results is normalized to account for transmission power and frequency allocation of respective cell sites, and the normalized data representing respective PIM detection results is correlated with data relating to a condition of respective cell sites and/or an environment of the respective cell sites to produce correlation results. The PIM diagnosis is generated in dependence on the correlation results.