Abstract: A minimally invasive spinal instrument and method for use of the same are disclosed. In some embodiments, a body includes an outer shaft and an inner shaft. A passageway accepts the inner shaft such that the outer shaft at least partially encloses the inner shaft. Each of the outer shaft and the inner shaft have spaced rings with locking grooves interleaved therewith. Each set of locking grooves is sized to accept a clamp such that the spaced rings mitigate longitudinal sliding of the clamp. A locking knob selectively secures the outer shaft and inner shaft thereto. A tip is removably secured to the inner shaft. In a single shaft configuration, in response to the locking knob being selectively disengaged from the outer shaft, the inner shaft and the locking knob are separated from the outer shaft such that the passageway is accessible to accept a metallic wire therethrough.

Abstract: A computing device displays a user interface containing a ribbon-shaped user interface. The ribbon-shaped user interface contains multiple tabs. Each of the tabs contains multiple controls. Furthermore, a challenge and a tab visualization control are displayed in the user interface. The challenge instructs a user of the computing device to perform a task using the ribbon-shaped user interface without instructing the user how to perform the task. In response to receiving selection of the tab visualization control, the computing device displays a popup window in the user interface. The popup window initially contains an image of an initial portion of a given tab in the ribbon-shaped user interface. The image of the given tab is scrolled within the popup window such that a target control in the given tab is visible within the popup window.

Abstract: A surface treating appliance, such as a vacuum cleaner, includes a main body, a surface treating head and a support assembly. The support assembly is rollably mounted to the main body for allowing the main body to be rolled along a surface. The support assembly also houses a component of the appliance, such as a motor for driving a surface-agitating device. Alternatively, or additionally, the support assembly may accommodate a fluid inlet for receiving fluid flow, a fluid outlet for exhausting fluid and a device for acting on the fluid flow received by the inlet such as a filter or suction apparatus.

Abstract: The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

Abstract: An accessory for a cleaning appliance includes a head having a housing, a downwardly-directed suction opening in the housing and a neck adapted for attachment to a hose or wand of the cleaning appliance. A rotatable connection is provided between the neck and the head for allowing rotation of the neck relative to the head. A wheel arrangement maneuverably supports the accessory on a surface to be cleaned and is mounted on the neck of the accessory. The wheel arrangement may normally be in contact with the surface to be cleaned, but the point or points of contact between the wheel arrangement and the surface to be cleaned are dependent upon the rotational position of the neck with respect to the head.

Abstract: The invention provides a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof. (I) wherein the groups Q, R2, R3, R4 and R5 represent various substituent groups, and their use as inhibitors of heparanase.

Abstract: A surface treating appliance, such as a vacuum cleaner, includes a main body, a surface treating head and a support assembly. The support assembly is rollably mounted to the main body for allowing the main body to be rolled along a surface. The support assembly also houses a component of the appliance, such as a motor for driving a surface-agitating device. Alternatively, or additionally, the support assembly may accommodate a fluid inlet for receiving fluid flow, a fluid outlet for exhausting fluid and a device for acting on the fluid flow received by the inlet such as a filter or suction apparatus.

Abstract: A surface treating appliance, such as a vacuum cleaner, includes a handle, a surface treating head and a support assembly. The support assembly is rollably mounted to the main body for allowing the main body to be rolled along a surface. A linkage is provided between the main body and the surface treating head and arranged such that rotating the main body about its longitudinal axis causes the surface treating head to turn in a new direction. The support assembly may house a component of the appliance, such as a motor, and may accommodate a fluid inlet for receiving fluid flow and a fluid outlet for exhausting fluid. The handle may carry the main body of the appliance.

Abstract: A surface treating appliance, such as a vacuum cleaner, includes a main body, a surface treating head and a support assembly. The support assembly is rollably mounted to the main body for allowing the main body to be rolled along a surface. The support assembly includes a substantially continuous rolling support surface that extends in a direction perpendicular to the longitudinal axis of the main body and is symmetrical about the longitudinal axis. The arrangement of the support surface and support assembly assists maneuverability of the appliance. The support assembly may house a component of the appliance, such as a motor, and may accommodate a fluid inlet for receiving fluid flow and a fluid outlet for exhausting fluid.

Abstract: The present invention relates to phthalimide carboxylic acid derivatives of formula (I), methods for their preparation, pharmaceutical compositions containing them and their use in medicine, specifically in the treatment of cancer. (I), wherein X is O or S; R1 is a phthalimide carboxylic acid group of formula (II). R is hydrogen, C1-C6 alkyl, aryl or C1-C3 alkylaryl and R2, R3 and R4 represent various substituents.

Abstract: A novel optical network simulation apparatus is disclosed for simulating a fiber optic link of a fiber optic network. In a first embodiment, an optical attenuator and two variable chromatic dispersion devices are used for imparting an attenuation and positive and negative chromatic dispersion, respectively, for an optical signal propagating from an input port to an output port of the optical network simulation apparatus. In a second embodiment, a polarization mode dispersion optical device is disposed between the input port to an output port of the optical network simulation apparatus in order to additionally provide polarization mode dispersion to the optical signal propagating from the input port to the output port of the optical network simulation apparatus. A microcontroller is used to control the components within the optical network simulation apparatus in order to perform the simulation for a plurality of different wavelengths.