Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: Solar wing positioning methods are provided which favorably reduce seasonal variation of generated power in a satellite while simultaneously managing the composite system influence that off-pointed solar wing operation imposes on the satellite. The composite system influence includes environmental torques and may also include other system influences such as wing-to-body thermal radiation, thruster plume impingement and antenna/sensor field of view encroachment. In the simplest method embodiment, the solar wings are tilted asymmetrically from a nominal position to reduce seasonal power variations and are further tilted symmetrically to generate a solar pressure torque component which, on a diurnal average basis, compensates a gravity gradient torque component that is substantially generated by the net, off-pointed configuration of the wings.

Abstract: Flexible, lightweight reflective sheets are positioned to concentrate solar radiation upon spacecraft solar panels. The sheets are held with inner and outer spring members which urge each sheet from a gathered edge-stowed configuration towards a deployed, planar configuration. The outer spring members further urge each fully extended sheet to rotate about an axis along the panel's edge in a direction away from the solar panel's face. Restraint members in the form of tethers limit this rotation to place the sheet in a stable deployed position and orientation chosen by design to reflect solar radiation onto the panel face. The increased incident radiation permits a reduction of the number of solar cells needed to satisfy a power requirement, and allows consequent savings in spacecraft cost and weight.