Patents by Inventor Stephen D. Holmes

Stephen D. Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Erythropoietin receptor antibodies
    Patent number: 6998124
    Abstract: Erythropoietin receptor agonist and antagonist antibodies and their use in enhancing erythropoiesis are disclosed.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: February 14, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Connie L. Erickson-Miller, Stephen D. Holmes, Alexander H. Taylor, Peter R. Young
  • Recombinant IL-18 antagonists useful in treatment of IL-18 mediated disorders
    Publication number: 20040141964
    Abstract: Chimeric, humanized and other IL-18 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
    Type: Application
    Filed: January 22, 2004
    Publication date: July 22, 2004
    Applicant: SmithKline Beecham Corporation and SmithKline Beecham p.l.c.
    Inventors: Sherin S. Abdel-Meguid, Yen Sen Ho, Stephen D. Holmes, Alexander H. Taylor
  • Monoclonal antibody and the method of using the antibody
    Patent number: 6706487
    Abstract: Chimeric, humanized and other IL-18 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: March 16, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Sherin S. Abdel-Meguid, Yen Sen Ho, Stephen D. Holmes, Alexander H. Taylor
  • RHAMM antagonist antibodies
    Publication number: 20020127227
    Abstract: The present invention provides antagonist monoclonal antibodies to human RHAMM (receptor for hyaluronic acid mediated notility) and to the use of these monoclonal antibodies as therapeutics for the treatment of proliferative diseases.
    Type: Application
    Filed: May 7, 2002
    Publication date: September 12, 2002
    Applicant: SmithKline Beecham Corporation
    Inventors: Stephen D. Holmes, Julie A. Abrahamson, Jeffrey R. Jackson
  • Human tumor necrosis factor receptor-like 2 (TR2) antibodies
    Publication number: 20020102258
    Abstract: The present invention relates to antibodies to novel members of the Tumor Necrosis Factor (TNF) receptor family called TR2 receptor and their uses in pathological conditions. Hybridoma cell lines producing such mAbs, methods of in vivo imaging of pathological conditions, and methods of treating and diagnosing pathological conditions, caused by abnormal functioning, production or metabolism of TR2 receptors are also provided. In vitro assays for detecting the presence of TR2 and for evaluating the binding affinity of a test compound are also described.
    Type: Application
    Filed: December 14, 2001
    Publication date: August 1, 2002
    Applicant: SmithKline Beecham Corporation
    Inventors: Jeremy A. Harrop, Stephen D. Holmes, Manjula P. Reddy, Alemseged Truneh
  • Tie2 antagonist antibodies
    Patent number: 6376653
    Abstract: Tie2 receptor antagonist antibodies, their use in inhibiting angiogenesis and other uses are disclosed.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: April 23, 2002
    Assignees: SmithKline Beecham plc, SmithKline Beecham Corporation
    Inventors: Stephen D. Holmes, Connie L. Erickson-Miller, James D. Winkler
  • Tie2 agonist antibodies
    Patent number: 6365154
    Abstract: Tie2 receptor agonist antibodies, their use in enhancing angiogenesis and other uses are disclosed.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: April 2, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.1.c.
    Inventors: Stephen D. Holmes, Connie L. Erickson-Miller, James D. Winkler
  • DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
    Patent number: 5928904
    Abstract: Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 27, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham P.L.C.
    Inventors: Stephen D. Holmes, Mitchell Stuart Gross, Daniel R. Sylvester
  • Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
    Patent number: 5914110
    Abstract: Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 22, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Stephen D. Holmes, Mitchell Stuart Gross, Daniel R. Sylvester
  • Method of diagnosing and monitoring colorectal cancer
    Patent number: 5726061
    Abstract: Methods of screening for colorectal cancer by measuring levels of HC gp-39 are provided. Methods of monitoring patients with colorectal cancer are also provided. In addition, kits for detection of HC gp-39 useful in screening for and monitoring of colorectal cancer in a patient are provided.
    Type: Grant
    Filed: October 8, 1996
    Date of Patent: March 10, 1998
    Assignee: SmithKline Beechum Corporation
    Inventors: David Robbins, Robert B. Kirkpatrick, Stephen D. Holmes