Patents by Inventor Stephen D. Patek

Stephen D. Patek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12285589
    Abstract: An insulin monitoring system includes one or more processors, one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include: first program instructions to track, in real time, the amount of insulin active in a patient; second program instructions to calculate the amount of insulin need of the patient by tracking the patient's metabolic states; third program instructions to compare the insulin active in the patient with the insulin need of the patient; and fourth program instructions to determine an insulin fault level based on the comparison.
    Type: Grant
    Filed: March 8, 2024
    Date of Patent: April 29, 2025
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Marc D. Breton, Stephen D. Patek, Boris P. Kovatchev
  • Patent number: 12266436
    Abstract: An insulin delivery supervisor (IDS) with a safety analysis and supervision function that can reside between the insulin request and the insulin delivery and can intercept any excessive insulin requests before the insulin was delivered. The IDS can be implemented in any system based on insulin pump or pen and will work with either SMBG or CGM modes of blood glucose monitoring.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: April 1, 2025
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Marc D. Breton, Stephen D. Patek, Boris P. Kovatchev, Colleen H. Karvetski
  • Publication number: 20250090052
    Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.
    Type: Application
    Filed: November 14, 2024
    Publication date: March 20, 2025
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Boris P. KOVATCHEV, Marc D. BRETON, Stephen D. PATEK
  • Publication number: 20250054597
    Abstract: A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention.
    Type: Application
    Filed: October 30, 2024
    Publication date: February 13, 2025
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Boris P. KOVATCHEV, Stephen D. PATEK, Marc D. BRETON
  • Patent number: 12178571
    Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: December 31, 2024
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Boris P. Kovatchev, Marc D. Breton, Stephen D. Patek
  • Patent number: 12144658
    Abstract: An amount of glycemic dysfunction associated with mis-timing (e.g., delay) of meal boluses based on replay analysis is determined. The amount of dysfunction of historical or estimated bolusing as compared to an optimally timed bolus based on the replay analysis is quantified and visualized. Inferences may be made about diabetes meal management regarding inputs from a patient.
    Type: Grant
    Filed: July 10, 2023
    Date of Patent: November 19, 2024
    Assignee: Dexcom, Inc.
    Inventors: Stephen D. Patek, Stephen J. Vanslyke
  • Publication number: 20240277933
    Abstract: Equivalent insulin pump retrospective virtual basal rates for daily injections are constructed from planned insulin injections according to a virtual basal rate profile developed for a patient, and a database of historical insulin injections, i.e. basal injections actually administered by the patient, providing a unified framework for analysis, design, optimization, and adaptation of MDI (multiple daily injections) and CSII (continuous subcutaneous insulin infusion (i.e. insulin pump) treatment parameters for patients with diabetes.
    Type: Application
    Filed: April 25, 2024
    Publication date: August 22, 2024
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Stephen D. PATEK, Marc D. BRETON
  • Publication number: 20240274300
    Abstract: A method and system use mathematical models and available patient information to virtualize a continuous glucose monitoring trace for a period of time. Such a method and system can generate the virtualized trace when episodic patient data is incomplete. Such a method and system can also rely on self-monitored blood glucose measurement information to improve the virtualized continuous glucose monitoring trace.
    Type: Application
    Filed: April 16, 2024
    Publication date: August 15, 2024
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Stephen D. PATEK, Marc D. BRETON
  • Publication number: 20240268669
    Abstract: In accordance with a method of communicating telemetry data employed by a risk-adaptive telemetry system, a medical device risk that a medical device will malfunction is assessed. A patient risk that the health of a patient using the medical device will fall below a predetermined acceptable level is also assessed. Telemetry data from the medical device is received, where type, amount and/or frequency of the telemetry data that is received is based at least in part on the assessed medical device risk and the patient risk.
    Type: Application
    Filed: February 7, 2024
    Publication date: August 15, 2024
    Inventors: Colin Anthony Steele, Stephen D. Patek
  • Patent number: 12057233
    Abstract: A method and system use mathematical models and available patient information to virtualize a continuous glucose monitoring trace for a period of time. Such a method and system can generate the virtualized trace when episodic patient data is incomplete. Such a method and system can also rely on self-monitored blood glucose measurement information to improve the virtualized continuous glucose monitoring trace.
    Type: Grant
    Filed: March 16, 2022
    Date of Patent: August 6, 2024
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Stephen D. Patek, Marc D. Breton
  • Publication number: 20240249810
    Abstract: An insulin delivery rate converter includes a comparator and an insulin delivery supervisor. The comparator is configured to receive insulin data and glucose data and to determine a difference delta between (i) estimations of metabolic data and behavior data derived from the insulin data and blood glucose measurements; and (ii) estimations of metabolic data and behavior data derived from the insulin data without use of the blood glucose measurements. The insulin delivery supervisor is configured to modulate an insulin delivery rate based at least in part on the difference delta determined by the comparator.
    Type: Application
    Filed: January 19, 2024
    Publication date: July 25, 2024
    Inventors: Stephen D. PATEK, Enrique Campos-Nanez, Matthew S. Gerber, Leah ZIEGLER, Thibault Pierre GAUTIER
  • Publication number: 20240249811
    Abstract: Adaptive on board estimation of exogenous pharmacon responsive to transient (i.e., impermanent) physiological effects is provided. Dynamically estimating an equivalent amount of an exogenous pharmacon on board (XOB), such as insulin and/or carbohydrates, left in the subject, is based on predictions of glucose time-series data. These estimated values, such as insulin on board (IOB), are useful for diabetes management software, including decision support and/or artificial pancreas (AP) algorithms, for example.
    Type: Application
    Filed: April 1, 2024
    Publication date: July 25, 2024
    Inventors: Stephen D. Patek, Enrique Campos-Nañez
  • Publication number: 20240245849
    Abstract: An insulin monitoring system includes one or more processors, one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include: first program instructions to track, in real time, the amount of insulin active in a patient; second program instructions to calculate the amount of insulin need of the patient by tracking the patient's metabolic states; third program instructions to compare the insulin active in the patient with the insulin need of the patient; and fourth program instructions to determine an insulin fault level based on the comparison.
    Type: Application
    Filed: March 8, 2024
    Publication date: July 25, 2024
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Marc D. BRETON, Stephen D. PATEK, Boris P. KOVATCHEV
  • Patent number: 12017045
    Abstract: Equivalent insulin pump retrospective virtual basal rates for daily injections are constructed from planned insulin injections according to a virtual basal rate profile developed for a patient, and a database of historical insulin injections, i.e. basal injections actually administered by the patient, providing a unified framework for analysis, design, optimization, and adaptation of MDI (multiple daily injections) and CSII (continuous subcutaneous insulin infusion (i.e. insulin pump)) treatment parameters for patients with diabetes.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: June 25, 2024
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Stephen D. Patek, Marc D. Breton
  • Patent number: 11986294
    Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.
    Type: Grant
    Filed: May 30, 2023
    Date of Patent: May 21, 2024
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Boris P. Kovatchev, Marc D. Breton, Stephen D. Patek
  • Patent number: 11978546
    Abstract: Adaptive on board estimation of exogenous pharmacon responsive to transient (i.e., impermanent) physiological effects is provided. Dynamically estimating an equivalent amount of an exogenous pharmacon on board (XOB), such as insulin and/or carbohydrates, left in the subject, is based on predictions of glucose time-series data. These estimated values, such as insulin on board (IOB), are useful for diabetes management software, including decision support and/or artificial pancreas (AP) algorithms, for example.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: May 7, 2024
    Assignee: DEXCOM, INC.
    Inventors: Stephen D. Patek, Enrique Campos-Náñez
  • Publication number: 20240136040
    Abstract: A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention.
    Type: Application
    Filed: December 20, 2023
    Publication date: April 25, 2024
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIN
    Inventors: Boris P. KOVATCHEV, Stephen D. PATEK, Marc D. BRETON
  • Patent number: 11951278
    Abstract: An insulin monitoring system includes one or more processors, one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include: first program instructions to track, in real time, the amount of insulin active in a patient; second program instructions to calculate the amount of insulin need of the patient by tracking the patient's metabolic states; third program instructions to compare the insulin active in the patient with the insulin need of the patient; and fourth program instructions to determine an insulin fault level based on the comparison.
    Type: Grant
    Filed: March 15, 2022
    Date of Patent: April 9, 2024
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Marc D. Breton, Stephen D. Patek, Boris P. Kovatchev
  • Publication number: 20240058533
    Abstract: An insulin device configured to control insulin dispensing based on insulin sensitivity. The insulin device includes a processor configured to receive insulin dosing schedule information, psychological stress level data, and body mass index (BMI) data; a sensor configured to generate a blood glucose level measurement. The sensor is calibrated as a function of the psychological stress level data and the BMI data and the processor is configured to monitor and detect changes of the blood glucose level measurement that are determined to have occurred as a function of changes of the psychological stress level data, and identify a time when the BMI data counteracts a detected change in the blood glucose level measurement. The insulin device also includes an insulin dispensing valve controlled by the processor to change the insulin dosing schedule information in accordance with the counteracting BMI data.
    Type: Application
    Filed: October 26, 2023
    Publication date: February 22, 2024
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Stephen D. PATEK, Basak OZASLAN, Linda GONDER-FREDERICK
  • Publication number: 20240058532
    Abstract: A continuous glucose monitor (CGM)-driven basal insulin titration system and method for patients with Type 2 Diabetes can be adapted to the needs and concerns of subjects just starting on basal insulin therapy. The method uses as inputs historical CGM data, basal insulin dose information, reports of hypoglycemia, and past recommendations and generates an adjusted insulin dose along with a report advising whether to continue the titration process, or to stop. The method can generate a new recommendation on a regular basis (e.g., each day) until it determines an adequate, consistent dose size.
    Type: Application
    Filed: October 24, 2023
    Publication date: February 22, 2024
    Inventors: Stephen D. Patek, Matthew S. Gerber, Enrique Campos-Nanez, Thibault Gautier, Leah Ziegler