Abstract: Devices and methods for selectively accessing tissue for sensing or drug release are provided. A device includes an array of wells formed in a substrate supporting a plurality of membranes. Each membrane is disposed at a well opening of one of the wells of the array. The device further includes an actuator and electronics configured to control the actuator to supply a vibration through the substrate. The supplied vibration is configured to selectively rupture one of the plurality of membranes at a defined timepoint to selectively give access to tissue through a well opening.