Patents by Inventor Stephen Darasch

Stephen Darasch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for alignment of DNA sequences with enhanced accuracy and read length
    Patent number: 6760668
    Abstract: In order to align DNA sequence data traces, an experimental data trace representing the positions of a first species of base within a target polynucleotide and a reference data trace representing the positions of a second species of base (which may be the same as or different from the first species) within a reference polynucleotide are obtained by separating appropriate sequencing fragments generated from the target and reference polynucleotides on an electrophoresis gel. For each reference data trace, a plurality of peaks corresponding to fragments having a size in the range of 40 to 1200 bases are selected. A base number is assigned to each of the selected peaks in the reference data trace, and a numerical “peak file” is created with information about the peak number and migration time (or distance).
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: July 6, 2004
    Assignee: Bayer HealthCare LLC
    Inventors: Alexandre Izmailov, Henryk Zaleski, Stephen Darasch