Patents by Inventor Stephen David Harrison

Stephen David Harrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR GENERATING SYNTHETIC LETHALITY IN TUMORS
    Publication number: 20240398799
    Abstract: The present disclosure provides methods for treating cancer comprising administering one or more therapeutic agents for manipulation of a target gene (e.g., protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1)), wherein the cancer has a mutation in, an altered (e.g., increased or decreased) expression level and/or an altered activity of a biomarker. Provided herein are methods for identifying biomarkers of the disclosure that form a synthetic lethal pair with a target gene (e.g., PKMYT1).
    Type: Application
    Filed: August 17, 2022
    Publication date: December 5, 2024
    Inventors: Stephen David HARRISON, Michael David WINTHER, Yuanyuan XIAO, Shawn YOST, Christine Taylor BREW, Yaron TURPAZ
  • COMPOSITIONS AND METHODS FOR GENERATING SYNTHETIC LETHALITY IN TUMORS
    Publication number: 20230078425
    Abstract: The present disclosure provides methods for treating cancer comprising administering one or more therapeutic agents for manipulation of a target gene (e.g., protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1)), wherein the cancer has a mutation in, an altered (e.g., increased or decreased) expression level and/or an altered activity of a biomarker. Provided herein are methods for identifying biomarkers of the disclosure that form a synthetic lethal pair with a target gene (e.g., PKMYT1).
    Type: Application
    Filed: August 17, 2022
    Publication date: March 16, 2023
    Inventors: Stephen David HARRISON, Michael David WINTHER, Yuanyuan XIAO, Shawn YOST, Christine Taylor BREW, Yaron TURPAZ
  • COMPOSITIONS AND METHODS FOR GENERATING SYNTHETIC LETHALITY IN TUMORS
    Publication number: 20230073494
    Abstract: The present disclosure provides methods for treating cancer comprising administering one or more therapeutic agents for manipulation of a target gene (e.g., protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1)), wherein the cancer has an altered (e.g., increased or decreased) expression level and/or activity of a biomarker. Provided herein are methods for identifying biomarkers of the disclosure that form a synthetic lethal pair with a target gene (e.g., PKMYT1).
    Type: Application
    Filed: August 17, 2022
    Publication date: March 9, 2023
    Inventors: Stephen David HARRISON, Michael David WINTHER, Yuanyuan XIAO, Shawn YOST, Christine Taylor BREW, Yaron TURPAZ
  • METHOD FOR PREDICTING AND EVALUATING RESPONSIVENESS TO CANCER TREATMENT WITH DNA-DAMAGING CHEMOTHERAPEUTIC AGENTS
    Publication number: 20180095085
    Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.
    Type: Application
    Filed: December 7, 2017
    Publication date: April 5, 2018
    Inventors: Ute Hoch, Christine Taylor Brew, Stephen David Harrison, Dennis G. Fry, Darren W. Davis
  • Method for predicting and evaluating responsiveness to cancer treatment with DNA-damaging chemotherapeutic agents
    Patent number: 9863949
    Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: January 9, 2018
    Inventors: Ute Hoch, Christine Taylor Brew, Stephen David Harrison, Dennis G. Fry, Darren W. Davis
  • METHOD FOR PREDICTING AND EVALUATING RESPONSIVENESS TO CANCER TREATMENT WITH DNA-DAMAGING CHEMOTHERAPEUTIC AGENTS
    Publication number: 20140357659
    Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 4, 2014
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Ute Hoch, Christine Taylor Brew, Stephen David Harrison, Dennis G. Fry, Darin W. Davis