Abstract: An improved actuator handle for a surgical instrument that can be used in endoscopic surgery with the emphasis on applying hemostatic clips. The instrument receives a longitudinal input from the actuator handle and translates the input into relative component motion to apply the hemostatic clips. The improved handle is fabricated primarily from a reusable, engineering resin having exceptional resistance to degradation by steam sterilization. Other improvements to the actuator handle include a drive stem mechanism of unitary construction that can be removed from the actuator handle as an assembled unit to facilitate sterilization. The actuator handle is provided with a quick release mechanism to facilitate the removal and replacement of the drive stem mechanism. The improved actuator handle also features a ratchet mechanism that enables the user to incrementally adjust the longitudinal input force that is transmitted to the surgical instrument and includes a switch for selective operation of the same.