Abstract: The present disclosure provides methods for lowering LDL-C levels in patients with homozygous familial hypercholes-terolemia (hoFH), the method comprising administering to the patient a pharmaceutical composition comprising a PCSK9 inhibitor. In certain embodiments, the PCSK9 inhibitor is an anti-PCSK9 antibody such as the exemplary antibody referred to herein as mAb316P.

Abstract: The present invention relates to compositions and methods for altering body composition in a subject, wherein the alteration of body composition is an increase in muscle mass and a reduction of fat mass simultaneously. The present invention also relates to compositions and methods for reducing fat mass in a subject. The compositions and methods also increase muscle volume and lean body mass in the subject. The present invention also relates to compositions that comprise a GDF8 inhibitor and an Activin A inhibitor and the use of such compositions to treat diseases and disorders characterized by increased fat mass, and/or decreased muscle volume.

Abstract: The present invention relates to compositions and methods for altering body composition in a subject, wherein the alteration of body composition is an increase in muscle mass and a reduction of fat mass simultaneously. The present invention also relates to compositions and methods for reducing fat mass in a subject. The compositions and methods also increase muscle volume and lean body mass in the subject. The present invention also relates to compositions that comprise a GDF8 inhibitor and an Activin A inhibitor and the use of such compositions to treat diseases and disorders characterized by increased fat mass, and/or decreased muscle volume.

Abstract: The disclosure provides compositions, kits, and methods of using a GDF-8 inhibitor to increase lean muscle mass. In embodiments, a GDF-8 inhibitor is an antibody or antigen binding fragment thereof that specifically binds GDF-8. In embodiments, a method comprises providing an exercise regimen for the subject, and administering a composition comprising an effective amount of a GDF-8 inhibitor.

Abstract: The disclosure provides compositions, kits, and methods of using a GDF-8 inhibitor to increase lean muscle mass. In embodiments, a GDF-8 inhibitor is an antibody or antigen binding fragment thereof that specifically binds GDF-8. In embodiments, a method comprises providing an exercise regimen for the subject, and administering a composition comprising an effective amount of a GDF-8 inhibitor.

Abstract: A toy system that includes a memory foam character body. In one version, the memory foam character body is flattened and stored in a fluid tight bag and mechanical restraining sleeve or envelope. In another version, a memory foam body cover and a container that is preferably rigid. The memory foam body is sculpted in the shape of a toy character and is highly compressible from an uncompressed sculpted shape into a compressed shape. A rigid container is provided to contain and maintain the encased sculpted memory foam character body in a compressed state. The rigid container has two or more parts that may be separated from one another to allow the encased sculpted memory foam character body to be compressed into the rigid container. Using these basic elements, the toy platform supports a broad range of selection and innovation in three broad categories: collectible toys; packaging innovation; and differentiated play platform.

Abstract: The present invention relates to compositions and methods for altering body composition in a subject, wherein the alteration of body composition is an increase in muscle mass and a reduction of fat mass simultaneously. The present invention also relates to compositions and methods for reducing fat mass in a subject. The compositions and methods also increase muscle volume and lean body mass in the subject. The present invention also relates to compositions that comprise a GDF8 inhibitor and an Activin A inhibitor and the use of such compositions to treat diseases and disorders characterized by increased fat mass, and/or decreased muscle volume.

Abstract: The disclosure provides compositions, kits, and methods of using a GDF-8 inhibitor to increase lean muscle mass. In embodiments, a GDF-8 inhibitor is an antibody or antigen binding fragment thereof that specifically binds GDF-8. In embodiments, a method comprises providing an exercise regimen for the subject, and administering a composition comprising an effective amount of a GDF-8 inhibitor.

Abstract: A magnetic top system for energizing, launching, and controlling movement of a spinning top. In one embodiment, a magnetic top launcher may magnetically couple to a top and induce a spinning motion in the top. A top controlling device may magnetically control a traversing movement of the top on a play surface without directly contacting the top.

Abstract: A magnetic top system for energizing, launching, and controlling movement of a spinning top. In one embodiment, a magnetic top launcher may magnetically couple to a top and induce a spinning motion in the top. A top controlling device may magnetically control a traversing movement of the top on a play surface without directly contacting the top.

Abstract: A magnetic top system for energizing, launching, and controlling movement of a spinning top. In one embodiment, a magnetic top launcher may magnetically couple to a top and induce a spinning motion in the top. A top controlling device may magnetically control a traversing movement of the top on a play surface without directly contacting the top.

Abstract: A magnetic top system for energizing, launching, and controlling movement of a spinning top. In one embodiment, a magnetic top launcher may magnetically couple to a top and induce a spinning motion in the top. A top controlling device may magnetically control a traversing movement of the top on a play surface without directly contacting the top.

Abstract: An embodiment of the present invention provides an interactive system for game playing. A user is provided with access to a website or software application to create a virtual scenario or storyline. The virtual storyline is saved to a storage device that is configured to fit into a game hub. When the storage device is placed in the game hub, the game hub is configured to play the storyline. In accordance with an embodiment of the present invention, the storyline can be displayed locally at the game hub to a user. In an embodiment of the present invention, active toys within a communications range of the game hub can be activated to perform actions in accordance with the storyline when the storyline is played by the game hub. In an embodiment of the present invention, actions performed by active toys are forwarded to the game hub and stored in the storage device in a storyline format for playing on a computing device.