Abstract: Described herein are MK2 inhibitors of Formula (II) and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of autoimmune disorders, chronic inflammatory disorders, acute inflammatory disorders, auto-inflammatory disorders, fibrotic disorders, metabolic disorders, neoplastic disorders, and cardiovascular or cerebrovascular disorders.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: A linear lighting device may include an elongated housing that defines a cavity. The linear lighting device may include plurality of emitter printed circuit boards configured to be received within the cavity. Each of the plurality of emitter printed circuit boards may include a plurality of emitter modules mounted thereto. Each of the plurality of emitter printed circuit boards may include a control circuit configured to control the plurality of emitter modules mounted to the respective emitter printed circuit board based on receipt of one or more messages. The linear lighting device may include a total internal reflection lens for each of the plurality of emitter printed circuit boards. The total internal reflection lens may be configured to diffuse light emitted by the emitter modules of the plurality of emitter printed circuit boards.

Abstract: Described herein are tricyclic PARP1 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of cancer.

Abstract: Described herein are PARP1 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of cancer.

Abstract: A data processing system implements detecting that a first user device associated with a first user has added a first sponsored content item to a host electronic document by adding a first reference to the first sponsored content item to the host electronic document. The first sponsored content item is stored separately in a memory of a cloud-based service from the host electronic document. The data processing system further implements determining that the first user has permission to share the first sponsored content item with other users of the cloud-based service, generating sponsor information to associate the sponsored content item with the host electronic document to permit users having access to the host electronic document to access the sponsored content item, and storing the sponsor information in a sponsored access datastore.

Abstract: A linear lighting device may include an elongated housing that defines a cavity. The linear lighting device may include plurality of emitter printed circuit boards configured to be received within the cavity. Each of the plurality of emitter printed circuit boards may include a plurality of emitter modules mounted thereto. Each of the plurality of emitter printed circuit boards may include a control circuit configured to control the plurality of emitter modules mounted to the respective emitter printed circuit board based on receipt of one or more messages. The linear lighting device may include a total internal reflection lens for each of the plurality of emitter printed circuit boards. The total internal reflection lens may be configured to diffuse light emitted by the emitter modules of the plurality of emitter printed circuit boards.

Abstract: Filler, processing fluid and silicone polymer are controllably compounded into homogeneous filled heat cured rubber compositions with requisite reinforcing properties and levels of volatiles. In the process, a continuous feed of a silicone polymer to a compounding apparatus is monitored and a signal is generated in accordance with the monitored rate of feed. Rate of feed of filler and additives to the compounding apparatus are then adjusted in accordance with the signal.

Abstract: A method for preparing a silicone emulsion, more particularly a method for preparing a silicone emulsion with a low cyclic siloxane level and particle size control.

Abstract: A method for preparing a silicone emulsion, more particularly a method for preparing a silicone emulsion with a low cyclic siloxane level and particle size control.